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Mechanism of action of 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicide on homoterm animals and humans

100%

Antonenko A. M., Blagaia A. V., Omelchuk S. T., Korshun M. M., Vavrinevych H. P., Milohov D. S., Pelo I. M., Bojar I.

Journal of Pre-Clinical and Clinical Research

2015

tom 09

nr 2

It was found that the main mechanisms of action of 4-hydroxyphenylpyruvatedioxygenase inhibitors are the development of tyrosinemia and alternations in thyroid hormone level as a result of hepatic enzyme induction. The main target organs of its action are the eyes, liver and thyroid gland. It was proved that the most adequate model for extrapolation of the effects of tyrosinemia on humans are mice, because their tyrosine aminotransferase activity level is similar to that in humans.

Ograniczanie wyników

1 Journal of Pre-Clinical and Clinical Research

1 Antonenko A. M.

1 Blagaia A. V.

1 Bojar I.

1 Korshun M. M.

1 Milohov D. S.

1 Omelchuk S. T.

1 Pelo I. M.

1 Vavrinevych H. P.

1 2015

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Mechanism of action of 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicide on homoterm animals and humans