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The role of nitric oxide in skeletal muscle regeneration

100%

Zembron-Lacny A., Orysiak J., Kalina K., Morawin B., Pokrywka A.

Trends in Sport Sciences

2013

tom 20

nr 4

Essential processes in the regeneration of an injured muscle include proliferation of satellite cells and vascularization. Myogenesis and angiogenesis are prerequisites for the subsequent morphological and functional healing of the injured muscle, leading to the reconstruction of the damaged myocytes and vessels, restoration of the blood fl ow and restoration of the oxygen supply to the tissue. Nitric oxide (NO) plays a key role in satellite cells activation. It acts as a signal molecule and vasodilator, promotes expression genes for many growth factors being extracellular signals regulating the functions of the muscular, vascular and nervous systems. NO is produced by three isoenzymes, called nitric oxide synthases (NOS), present in skeletal muscle. The disturbance equilibrium between eNOS and iNOS activities results in pro-apoptotic NO activity and muscle atrophy. A recent study has shown a relationship between NO generation and delayed onset muscle soreness in response to intense resistance exercise. NO generation can be modulated by physical activity, systemic hypoxia (altitude training) or NO precursors such as L-arginine. The present review provides a current overview of NO effects on skeletal muscles and nutritional strategies based on L-arginine intake to aid muscle regeneration.

Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor delta (GW501516) and 5-aminoimidazole- 4-carboxamide ribonucleotide (AICAR)

86%

Pokrywka A., Cholbinski P., Kaliszewski P., Kowalczyk K., Konczak D., Zembron-Lacny A.

Journal of Physiology and Pharmacology

2014

tom 65

nr 4

Analysis and bioanalysis: an effective tool for data collection of environmental conditions and processes

86%

Szczepanska N., Owczarek K., Kudlak B., Pokrywka A., Mazerska Z., Galuszka A., Namiesnik J.

Polish Journal of Environmental Studies

2016

tom 25

nr 1

Reliable information that allows us to estimate the state of the environment and to forecast changes in the ecosystem are constantly required. Increasing environmental consciousness and dynamic development of analytical techniques are the main reasons for determining the wide range of pollutants occurring at very low concentrations in complex matrix samples. The presence and concentration of many of those pollutants in the environment are not yet subjected to legal regulations, so development of new methodologies to ensure good quality of results and their control are essential. This paper presents the target and development directions currently observed in environmental monitoring and biomonitoring. A lot of attention has been paid to a wide range of compounds that are endocrine disruptors. The overview of analytical approaches and procedures used to detect and to determine biologically active compounds can be found in this paper as well.

Ograniczanie wyników

1 Journal of Physiology and Pharmacology

1 Polish Journal of Environmental Studies

1 Trends in Sport Sciences

3 Pokrywka A.

2 Zembron-Lacny A.

1 Cholbinski P.

1 Galuszka A.

1 Kalina K.

1 Kaliszewski P.

1 Konczak D.

1 Kowalczyk K.

1 Kudlak B.

1 Mazerska Z.

1 Morawin B.

1 Namiesnik J.

1 Orysiak J.

1 Owczarek K.

1 Szczepanska N.

1 2016

1 2014

1 2013

Wyniki wyszukiwania

The role of nitric oxide in skeletal muscle regeneration

Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor delta (GW501516) and 5-aminoimidazole- 4-carboxamide ribonucleotide (AICAR)

Analysis and bioanalysis: an effective tool for data collection of environmental conditions and processes