The paper presents three cases of side effects of the following veterinary drugs in cattle: 1) inactivated vaccines against IBR/IPV and BVD/MD, 2) a live vaccine against BRSV and/or 3) β-carotene in Carofertin. In the first case, as an effect of a simultaneous intramuscular vaccination of 150 cows with inactivated vaccines against IBR/IPV and BVD/MD, classical allergy sings with urticaria, strong oedema at the injection site and head swelling occurred in 12 (8%) animals. Shortly after anti-inflammatory treatment, all sings disappeared. In the second case, an intranasal inoculation of newly purchased calves with a vaccine against BRSV caused a severe immune depression manifesting itself in a sudden strong diarrhea and death of 18 out of 20 calves (90%) within a few days after vaccination. This may have resulted from the fact that the animals had been vaccinated shortly after transportation, during the adaptation time. In the third case, an intramuscular administration of Carofertin to one cow caused hypersensitivity in the form of urticaria, the swelling of the eyelids and the udder, as well as vulval oedema of the vulvae. Treatment was successful, and all alarming signs subsided. Possible reasons for these rapid reactions are widely discussed.
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