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A pilot study to establish an ovalbumin-induced atopic dermatitis minipig model

100%

Kim Y. K., Lee J. Y., Hwang H., Suh H. N.

Journal of Veterinary Research

2021

tom 65

nr 3

Ambivalent role of gallated catechins in glucose tolerance in humans: A novel insight into non-absorbable gallated catechin-derived inhibitors of glucose absorption

64%

Park J. H., Jin J. Y., Baek W. K., Park S. H., Sung H. Y., Kim Y. K., Lee J., Song D. K.

Journal of Physiology and Pharmacology

2009

tom 60

nr 4

101-109

Prolonged postprandial hyperglycemia is a detrimental factor for type 2 diabetes and obesity. The benefit of green tea extract (GTE) consumption still requires confirmation. We report the effects of circulating green tea catechins on blood glucose and insulin levels. Oral glucose loading 1 h after GTE ingestion in humans led to higher blood glucose and insulin levels than in control subjects. Gallated catechins were required for these effects, although within the intestinal lumen they have been known to decrease glucose and cholesterol absorption. Treatment with epigallocatechin-3-gallate hindered 2-deoxyglucose uptake into liver, fat, pancreatic beta-cell, and skeletal muscle cell lines. The glucose intolerance was ameliorated by gallated catechin-deficient GTE or GTE mixed with polyethylene glycol, which was used as an inhibitor of intestinal absorption of gallated catechins. These findings may suggest that the gallated catechin when it is in the circulation elevates blood glucose level by blocking normal glucose uptake into the tissues, resulting in secondary hyperinsulinemia, whereas it decreases glucose entry into the circulation when they are inside the intestinal lumen. These findings encourage the development of non-absorbable derivatives of gallated catechins for preventative treatment of type 2 diabetes and obesity, which would specifically induce only the positive luminal effect.

The functional effect of epigallocatechin gallate on ischemic stroke in rats

64%

Lim S. H., Kim H. S., Kim Y. K., Kim T.-M., Ima S., Chung M. E., Hong B. Y., Ko Y. J., Kim H. W., Lee J. I.

Acta Neurobiologiae Experimentalis

2010

tom 70

nr 1

We evaluated the efficacy of epigallocatechin gallate (EGCG) for improving function in rats with transient middle cerebral artery occlusion (MCAO). Three procedures underwent for each groups; MCAO and EGCG treatment, MCAO without treatment (MCAO control), and sham operation. Function was evaluated on days 1, 5, 10, and 14 after ischemia, using a modified sticky-tape test and the percentage weight borne on the paretic leg. Infarct volume did not differ between the EGCG-treated and MCAO control groups. Compared with the MCAO control group, the EGCG-treated group showed improved forelimb function and had normal function by day 10 (P<0.05). The improvements persisted until day 14 post-ischemia. In contrast, hind limb function did not differ between the EGCG-treated and MCAO control groups. Thus, EGCG improved certain aspects of function of forelimb until day 14 after MCAO in rats.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Journal of Physiology and Pharmacology

1 Journal of Veterinary Research

3 Kim Y. K.

1 Baek W. K.

1 Chung M. E.

1 Hong B. Y.

1 Hwang H.

1 Ima S.

1 Jin J. Y.

1 Kim H. S.

1 Kim H. W.

1 Kim T.-M.

1 Ko Y. J.

1 Lee J.

1 Lee J. I.

1 Lee J. Y.

1 Lim S. H.

1 Park J. H.

1 Park S. H.

1 Song D. K.

1 Suh H. N.

1 Sung H. Y.

1 2021

1 2010

1 2009

Wyniki wyszukiwania

A pilot study to establish an ovalbumin-induced atopic dermatitis minipig model

Ambivalent role of gallated catechins in glucose tolerance in humans: A novel insight into non-absorbable gallated catechin-derived inhibitors of glucose absorption

The functional effect of epigallocatechin gallate on ischemic stroke in rats