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Moderate exercise decreases nitric oxide exhalation in patients with stable coronary artery disease

100%

Nadziakiewicz P., Knapik P., Ziora D., Nowak D.

Journal of Physiology and Pharmacology. Supplement

2006

tom 57

nr 4

213-221

Nitric oxide (NO) is present in exhaled air in humans and its level may decrease in heart diseases. Nitrates are metabolized to NO. In the present study we prospectively investigated how coronary disease treated with oral nitrates and physical exercise influence the exhaled NO concentration (exNO). The study was performed in 44 patients with stable coronary artery disease (CAD) treated with oral nitrates (31 nonsmokers and 13 smokers) and 34 healthy volunteers (21 nonsmokers and 13 smokers). End-tidal concentration of exhaled NO was measured by the use of a chemiluminescence method. The Bruce protocol of an exercise test was performed in 21 coronary patients and 11 volunteers. NO was measured before and 2-5 min after the test. We found no significant differences in the exNO level between healthy controls and CAD patients as analyzed either for the whole groups or non-smoker and smoker subgroups (6.01 parts per billion (ppb) vs. 4.91 ppb; 7.02 ppb vs. 5.89 ppb; 3.62 ppb vs. 3.33 ppb, respectively). However, the coronary patients group, as a whole, had lower exNO after exercise (4.22 ppb vs. 3.84 ppb, P<0.01). The difference persisted after division of this group into non-smokers and smokers: 5.19 ppb vs. 4.79 ppb, P<0.05 and 3.63 ppb vs. 3.27 ppb, P<0.05, respectively). The level of exNO changed inappreciably after exercise in control subjects. We conclude that coronary disease and oral nitrates, in themselves, do not influence the exhaled NO concentration. Physical exercise, on the other side, lowers the exhaled NO level in coronary patients.

Potential confounding factors in measurement of exhaled nitric oxide

76%

Nadziakiewicz P., Knapik P., Rozentryt P., Ziora D., Dworniczak S., Kozielski J., Polonski L.

Journal of Physiology and Pharmacology. Supplement

2006

tom 57

nr 4

223-228

Nitric oxide is present in the exhaled air. Factors affecting the level of exhaled nitric oxide (exNO), except for smoking, are not well defined. In this study we seek to determine whether age, gender, body mass index (BMI), part of the day, or time after a meal could modulate exNO levels. exNO was examined by the use of a chemiluminescence method in 100 subjects - 31 women (19 nonsmokers and 12 smokers) and 69 males (55 nonsmokers and 14 smokers). Forty four subjects took medications due to stable coronary disease, 22 were after heart transplantation, and 34 did not take any drugs. We found that exNO levels did not differ either between the whole groups of women and men or between smokers and nonsmokers of either respective group (4.91 ±2.38 vs. 6.27 ±4.23 ppb; 3.21 ±1.16 vs. 3.71 ±1.55 ppb; 5.98 ±2.35 vs. 6.92 ±4.45 ppb). The correlation of exNO with age in the whole population was weak (r=0.23; P=0.02) and insignificant in the smoking and nonsmoking subgroups. Likewise, correlations of exNO with BMI, part of the day, or time after a meal were insignificant in whole population as well as the subgroups. We conclude that the aforementioned factors are not able to confound the measurement of exNO in the population studied.

Exhaled nitric oxide concentration in patients after heart transplantation

76%

Nadziakiewicz P., Knapik P., Zakliczynski M., Zembala M., Urbanska E., Pacholewicz J.

Journal of Physiology and Pharmacology. Supplement

2007

tom 58

nr 5

Ograniczanie wyników

3 Journal of Physiology and Pharmacology. Supplement

3 Knapik P.

3 Nadziakiewicz P.

2 Ziora D.

1 Dworniczak S.

1 Kozielski J.

1 Nowak D.

1 Pacholewicz J.

1 Polonski L.

1 Rozentryt P.

1 Urbanska E.

1 Zakliczynski M.

1 Zembala M.

1 2007

2 2006

Wyniki wyszukiwania

Moderate exercise decreases nitric oxide exhalation in patients with stable coronary artery disease

Potential confounding factors in measurement of exhaled nitric oxide

Exhaled nitric oxide concentration in patients after heart transplantation