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Polymorphism and structure of exon 2 of caprine melatonin receptor 1b gene and its relations to fertility and seasonal estrus

100%

Jia L., Chu M. X., Di R., Cao G., Feng T., Chen H., Sun J., Fang L.

Animal Science Papers and Reports

2012

tom 30

nr 2

The first description is presented of nucleotide sequence of exon 2 of caprine melatonin receptor 1b (MT2). No polymorphisms of MT2 gene were detected between high fertility and year-round estrous goat breeds and low fertility and seasonal estrous goat breeds. It is likely that exon 2 of MT2 gene is not associated with fertility or reproductive seasonality in goat breeds. The nucleotide sequence of exon 2 of MT2 gene of Jining Grey goats shows much closer phylogenetic relation to the MT2 of sheep (97%) and cattle (94%) than to that of pig (84%), human (80%) and mouse (74%). A rather high nucleotide identity (62-64%) with the melatonin receptor 1a (MT1) of goat, sheep, human and mouse was also found. The caprine MT2 contains the same NAXXY motif in transmembrane 7 as the other melatonin receptors. Both DRY and CYVCR motifs were detected just downstream from its third transmembrane domain (the same as in sheep and cattle) rather than NRY and CYICH found in other melatonin receptor groups.

Polymorphism in exon 2 of INHBB gene and its relationship with litter size in Jining Grey goats

100%

Chu M. X., Peng Z. L., Chen H. Q., Zhang Y. J., Fang L., Di R., Cao G. L., Feng T., Li N.

Animal Science Papers and Reports

2012

tom 30

nr 1

The inhibin βB (INHBB) gene was studied as a candidate gene for the prolificacy of Jining Grey goats. According to the sequence of bovine INHBB gene, two pairs of primers were designed to detect single nucleotide polymorphism in exon 2 of INHBB gene in high-prolificacy (Jining Grey)and low-prolificacy (Inner Mongolia Cashmere and Angora) goats by polymerase chain reactionsingle strand conformation polymorphism method. Only the amplified products of primer P2 showed polymorphism. Three genotypes (AA, AB and BB) were identified in Jining Grey and two (AB and BB) in Inner Mongolia Cashmere and Angora goats. Sequencing revealed one single nucleotide mutation (A→G) at base 782 of exon 2 of INHBB gene in BB genotype compared to genotype AA.

Ograniczanie wyników

2 Animal Science Papers and Reports

2 Chu M. X.

2 Di R.

2 Fang L.

2 Feng T.

1 Cao G.

1 Cao G. L.

1 Chen H.

1 Chen H. Q.

1 Jia L.

1 Li N.

1 Peng Z. L.

1 Sun J.

1 Zhang Y. J.

2 2012

Wyniki wyszukiwania

Polymorphism and structure of exon 2 of caprine melatonin receptor 1b gene and its relations to fertility and seasonal estrus

Polymorphism in exon 2 of INHBB gene and its relationship with litter size in Jining Grey goats