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Neuroendocrine response during stress with relation to gender differences

100%

Jezova D., Jurankova E., Mosnarova A., Kriska M., Skultetyova I.

Acta Neurobiologiae Experimentalis

1996

tom 56

nr 3

Reduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGB 761) in healthy volunteers

100%

Jezova D., Duncko R., Lassanova M., Kriska M., Moncek F.

Journal of Physiology and Pharmacology

2002

tom 53

nr 3

The standardized extract of Ginkgo biloba (EGb 761) was found not only to improve memory and aging associated cognitive deficits but also to exert beneficial effects on mood. An antistress action of the extract has been suggested but not directly proven. The present study was aimed to evaluate the effects of EGb 761 on salivary cortisol and blood pressure responses during stress in healthy young volunteers (n=70) in a double blind placebo controlled design. A stress model involving a combination of static exercise (handgrip) and mental stimuli was used. Single treatment with EGb 761 (120 mg) reduced stress-induced rise in blood pressure without affecting the heart rate. Salivary cortisol responses showed differences with respect to the gender and the time of day of the stress exposure, with the activation only in male subjects in the afternoon. This activation was absent if they were treated with EGb 761. The performance in a short memory test with higher scores achieved by women remained unaffected by EGb 761 treatment. Thus, this study provides evidence that EGb 761 has an inhibitory action on blood pressure and it may influence cortisol release in response to some stress stimuli.

Stress-induced rise in endothelaemia, von Willebrand factor and hypothalamic-pituitary-adrenocortical axis activation is reduced by pretreatment with pentoxifylline

86%

Jezova D., Kristova V., Slamova J., Mlynarik M., Pirnik Z., Kiss A., Kriska M.

Journal of Physiology and Pharmacology

2003

tom 54

nr 3

Stress is considered to be a risk factor of several diseases. The following hypotheses were tested: (1) single exposure to an intensive stressor is followed by endothelial stimulation and/or damage to endothelial cells, (2) potential stress-induced endothelial cell damage is reduced by repeated pretreatment with pentoxifylline and (3) pentoxifylline treatment modifies neuroendocrine activation during stress reflected by changes in hypothalamic-pituitary-adrenocortical (HPA) axis function. Rats were treated with saline or pentoxifylline (20 mg/kg, s.c.) once daily for 7 days and then exposed to single immobilization stress for 20 or 120 min. In saline pretreated rats, stress exposure was followed by a rise in endothelaemia, von Willebrand factor concentrations, adrenocorticotropic hormone (ACTH) and corticosterone release, as well as by enhanced gene expression of hypothalamic corticotropin releasing factor (CRH). Stress-induced changes were reduced by pretreatment with pentoxifylline. Significant inhibition was observed in endothelaemia, plasma ACTH and corticosterone concentration in the adrenals. Thus, signs of endothelial injury as well as stress-induced hormone levels were reduced by pretreatment with pentoxifylline, although there is no evidence for a causal relationship. This protective action of pentoxifylline might be of benefit in the prevention and therapy of some stress-related disorders.

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Acta Neurobiologiae Experimentalis

3 Jezova D.

3 Kriska M.

1 Duncko R.

1 Jurankova E.

1 Kiss A.

1 Kristova V.

1 Lassanova M.

1 Mlynarik M.

1 Moncek F.

1 Mosnarova A.

1 Pirnik Z.

1 Skultetyova I.

1 Slamova J.

1 2003

1 2002

1 1996

Wyniki wyszukiwania

Neuroendocrine response during stress with relation to gender differences

Reduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGB 761) in healthy volunteers

Stress-induced rise in endothelaemia, von Willebrand factor and hypothalamic-pituitary-adrenocortical axis activation is reduced by pretreatment with pentoxifylline