Monensin is an ionophore antibiotic that changes the population of rumen bacteria. The aim of this study was to determine the effects of monensin controlled capsule administered 3 wk before calving on blood metabolites (serum beta-hydroxybutiric acid (BHBA), cholesterol (CHOL), urea, creatinine (CREA), gamma glutamyl transferase (GGT), aspartate aminotransferase (AST), total protein (TP), phosphorus (P), magnesium (Mg+), calcium (Ca++), glucose (GLU) and plasma non-esterified fatty acids (NEFA) concentration) and milk yield in the pre and post-calving term. 50 Holstein-Friesian cows were selected from the same flock. Blood samples were taken 3 weeks before the expected calving date and during weeks 1, 2, 4, 6 and 8 post calving. Cows were divided into two group: a study group (Group M, n:40) and a control group (Group C, n: 10). The group M orally received a cylindrical device (Kexxtone, ELANCO Animal Health, Guelph, ON, Canada) and the group C received no treatment. BHBA and NEFA was lower (P˂0,.05) in group M compared with group C in the 6 and 8 week post-calving. GLU was higher (P˂0.05) in group M compared with group C in the 4 week post-calving. Urea was higher (P˂0.05) in group M compared with group C in the 1 week post-calving. There was no statistically difference between two groups (P˂0.05) in milk yields. Although milk yield was similar in both groups, the change in concentration of BHBA, NEFA, GLU and urea showed that monensin CRC could be as a glycogenic precursor.
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