Wyniki wyszukiwania

1

Co-treatment with probucol does not improve lung pathology in hydroxypropyl-beta-cyclodextrin-treated Npc1−/− mice

100%

Erickson R. P., Borbon I. A.

Journal of Applied Genetics

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2019

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tom 60

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nr 2

2

Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer’s

100%

Borbon I. A., Erickson R. P.

Journal of Applied Genetics

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2011

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tom 52

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nr 2

Although Niemann-Pick C1 disease has frequently been called “juvenile Alzheimer’s”, the effects of introducing Npc1 mutations into a mouse model of Alzheimer’s have not previously been performed. We have crossed Npc1 +/− mice with APP/PS1 “Alzheimer’s” mice and studied Aβ42 accumulation and amyloid plaque formation. Mice heterozygous for Npc1 and positive for the APP and PS1 transgenes accumulated Aβ42 more rapidly than the APP/PS1 controls and this correlated, as expected, with the area of amyloid plaques. We conclude that the alterations of intracellular cholesterol present in Npc1 +/− mice can influence the progress of Alzheimer’s disease in the APP/PS1 mouse model.

3

Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease

80%

Marshall C. A., Borbon I. A., Erickson R. P.

Journal of Applied Genetics

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2017

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tom 58

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nr 1

Ograniczanie wyników

3 Journal of Applied Genetics

3 Borbon I. A.

3 Erickson R. P.

1 Marshall C. A.

1 2019

1 2017

1 2011

Co-treatment with probucol does not improve lung pathology in hydroxypropyl-beta-cyclodextrin-treated Npc1−/− mice

Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer’s

Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease