The anti-inflammatory effect of three plants of Cucurbitaceae family: Ecballium elaterium, Cucumis prophetarum and Luffa cylindrica were studied using their petroleum ether and alcohol extracts. The recorded LD50 due to i.p. administration of petroleum ether of E. elaterium and L. cylindrica and alcohol of C.prophetarum, as representative extracts, were 3.4, 0.45 and 1.5 g/kg b.wt., respectively. The carrageenan induced edema in rats was significantly reduced by pre-treatment with petroleum ether extract of E. elaterium, C.prophetarum herbs and Luffa cylindrica fruits after 2h, while alcohol extract of E. elaterium herb caused a maximum inhibition of edema which amounted to 76.9% in comparison with the other extracts.
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