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Testing of bathroom furniture elements exposed to variable climatic conditions. Performance of 10 most common materials and technologies used in bathroom furniture was tested in varying climate, commonly met in bathroom indoors. Tested variants were chosen based on appearance in bathroom furniture. The influence of varying humidity as well as liquid water was tested. Swell and load carrying capacity of eccentric joint's bolts were used as performance indicators. Materials that meet requirements of bathroom conditions in a best way were V313 HMR materials. Ordinary V20 materials should not be applied for bathroom furniture unless carefully lacquered, local damage of lacquer surface is very dangerous point in that case however, as it lead to immediate destruction of core material.
New design of furniture front panels and possibility of their production. In this paper new designed furniture front panels are presented. New design forced to choose materials and methods that gives possibility to manufacture front panels veneered with original intarsia. Veneers of beech wood were thermally modified to get desired colours and cutting was done using laser techniques.
Focal cortical dysplasia (FCD) is a developmental brain disorder characterized by abnormalities of cytoarchitecture and neuronal morphology. FCD is associated with pharmacologically intractable forms of epilepsy in both children and adults. The mechanisms that underlie FCD-associated seizures are unclear. It is believed that a pathological plasticity, including abnormality of synaptic connections, plays the crucial role in this disease. Recent studies indicate the role of interactions between nerve cells and the extracellular matrix in the processes of plasticity. Matrix metalloproteinases are enzymes, which are able to degrade the extracellular matrix components, so they can play an important role in these interactions. Results of experiments using rodent models showed that extracellular matrix metalloproteinase-9 (MMP-9) can play an important role in epileptogenesis. There is no data demonstrating that MMP-9 is involved in the development of epilepsy in human. The aim of this study was to determine whether MMP-9 might play a role in FCD - related epilepsy. Expression of MMP-9 was investigated in human brain tissue derived from people suffering from epilepsy. The immunohistochemistry and antibody microarray methods were used. The control group consisted of the autopsy brain samples. The results indicate that the expression of MMP-9 in the human brain tissue with FCD is increased. The highest immunoreactivity occurs in cytoplasm of abnormal neurons. Moreover, among the 7 tested matrix metalloproteinases (MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, MMP-13), MMP-9 is present in greatest concentration in the FCD tissue homogenates. The results support the hypothesis of the possible role of MMP-9 in the development of human epilepsy and give an opportunity to develop new treatments.
Introduction: Neurological disorders are the most common cause of serious disability and have a major impact on financial healthrelated burden to society. Most of them are definitely associated with cell death: sudden or chronic. Conventional treatment methods yield disappointing results. Thus the discoveries in stem cell biology have fueled the interest in cell-based therapeutical approach. Based on experimental data cord blood has been proposed as a novel, autologous cell source for pediatric population. Non-invasive monitoring of cell fate following transplantation has been recently recommended as a basis for rational stem cell therapy. Subject: One year old child experienced devastating, cardiac arrest-induced cerebral ischemia. Despite a broad rehabilitation program diagnose of vegetative state has been established three months later. After next three months of continued rehabilitation no noticeable improvement has also been found and the child has been included into study. The protocol has been approved by the ethical commission of The Children’s Memorial Health Institute in Warsaw, Poland. Then the child’s own cord blood cells have been neurally-converted over 10 days in culture within GMP facility. Prior to transplantation cells were labeled with iron oxide (SPIO) for MR imaging. For scaling sensitivity of MR signal different concentrations of SPIO-labeled cells were scanned in the phantom. Then patient received monthly 3 subsequent cell infusions (1.2 x 107 cells each) to lateral ventricles. The follow up continued up to 6 months and included both clinical assessment and MR examinations. Results: High efficiency of neural cell conversion and SPIO labeling as well as no cytotoxicity were observed. The employed method of cell transplantation was found to be efficient to deliver cells to CNS as confirmed by MR imaging. Gradual decrease of SPIO signal intensity was observed over the period of follow up. No adverse events or abnormal reaction to cell implantation was detected. The follow up revealed mild functional improvement - decreased nystagmus, spasticity and the number of epileptic seizures. Moreover, the features of the child contact with parents has appeared, thus vegetative state can not be diagnosed any more. Conclusions: This report indicates that transplantation of autologous, neurally-committed cord blood-derived cells to the ventricular system of child is safe, feasible and able to result with mild functional improvement. Additionally cell-related MRI signal can be monitored for more than 4 months in transplanted brain hemisphere. Supported by MSHE grants no 0141/B/P01/2008/35 and 0142/B/ P01/2008/35.
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