Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 29

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Afront czy niemoc

100%
Jakubowski H.
Nowoczesne Rolnictwo. Nauka, Doradztwo, Praktyka
|
1996
|
tom 03
|
nr 12
10
2
Content available remote

The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease

100%
Jakubowski H.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 9
155-167
3

Synthesis of diadenosine 5',5'''-P^1,P^4-tetraphosphate and related compounds by plant (Lupinus luteus) seryl-tRNA and phenylalanyl-tRNA synthetases

100%
Jakubowski H.
Acta Biochimica Polonica
|
1983
|
tom 30
|
nr 1
4

Quality control in tRNA charging - editing of homocysteine

100%
Jakubowski H.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 2
 All living organisms conduct protein synthesis with a high degree of accuracy maintained in the transmission and flow of information from a gene to protein product. One crucial "quality control" point in maintaining a high level of accuracy is the selectivity by which aminoacyl-tRNA synthetases furnish correctly activated amino acids, attached to tRNA species, as the building blocks for growing protein chains. When differences in binding energies of amino acids to an aminoacyl-tRNA synthetase are inadequate, editing is used as a major determinant of enzyme selectivity. Some incorrect amino acids are edited at the active site before the transfer to tRNA (pre-transfer editing), while others are edited after transfer to tRNA at a separate editing site (post-transfer editing). Access of natural non-protein amino acids, such as homocysteine, homoserine, or ornithine to the genetic code is prevented by the editing function of aminoacyl-tRNA synthetases. Disabling editing function leads to tRNA mischarging errors and incorporation of incorrect amino acids into protein, which is detrimental to cell homeostasis and inhibits growth. Continuous homocysteine editing by methionyl-tRNA synthetase, resulting in the synthesis of homocysteine thiolactone, is part of the process of tRNA aminoacylation in living organisms, from bacteria to man. Excessive homocysteine thiolactone synthesis in hyperhomocysteinemia caused by genetic or nutritional deficiencies is linked to human vascular and neurological diseases.
5

The plant aminoacyl-tRNA synthetases. 2'-deoxyATP and ATP in reactions catalysed by yellow lupin aminoacyl-tRNA synthetases

100%
Jakubowski H.
Acta Biochimica Polonica
|
1980
|
tom 27
|
nr 3-4
6

From accuracy in protein synthesis to cardiovascular disease: The role of homocysteine

100%
Jakubowski H.
Biotechnologia
|
2002
|
nr 3
7

Syntetazy aminoacylo-tRNA

75%
Jakubowski H.
Postępy Biochemii
|
1975
|
tom 21
|
nr 1
8

Paraoxonase 1 and dietary hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis

63%
Suszynska-Zajczyk J., Jakubowski H.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 4
9

Valyl-tRNA synthetase of yellow lupin seeds. Purification and some properties

63%
Jakubowski H., Pawelkiewicz J.
Acta Biochimica Polonica
|
1974
|
tom 21
|
nr 3
10

The plant aminoacyl-tRNA syntheases. Effect of sodium chloride on tRNA aminoacylation and aminoacyl-tRNA decomposition catalysed by aminoacyl-tRNA synthetases from yellow lupin seeds

63%
Jakubowski H., Pawelkiewicz J.
Acta Biochimica Polonica
|
1977
|
tom 24
|
nr 2
11

Tur - wygasly przodek bydla domowego

63%
Frackowiak H., Jakubowski H.
Bydło
|
2008
|
nr 03
32-34
12

"Molecular Biology Now and Tomorrow, Thirty Tears of DNA", September 19-21, 1983, Boston Park Plaza Hotel and Towers, Boston, Mass., USA

63%
Jakubowski H.
Postępy Biochemii
|
1984
|
tom 30
|
nr 3-4
13

Comparative studies of blood vessels in the hamster, rat and guinea pig

51%
Zywert A., Jakubowski H., Frackowiak H., Mackowiak P.
Acta Biologica Cracoviensia. Series Zoologia
|
2009
|
tom 51
55-61
14

Endrogenous and exogenous polyamines in dormancy breaking of Acer platanoides seeds under conditions of cold stratification

51%
Szczotka Z., Lewandowska U., Jakubowski H.
Acta Physiologiae Plantarum
|
1988
|
tom 10
|
nr 3
15

Sex affects homocysteine modification at lysine residue 212 of albumin in mice

51%
Sikora M., Marczak L., Perla-Kajan J., Jakubowski H.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
16

The nomenclature of 1-aminoalkylphosphonic acids and derivatives: evolution of the code system

51%
Drabowicz J., Jakubowski H., Kudzin M. H., Kudzin Z. H.
Acta Biochimica Polonica
|
2015
|
tom 62
|
nr 1
17

Changes in MUPs expression patterns induced by Cbs deficiency in mice are mediated by liver Zhx2 and androgene receptor

51%
Wroblewski J., Bretes E., Jakubowski H.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr S2
18

Morphometry of intestines of the raccoon dog (Nyctereutes procyonoides)

51%
Kulawik M., Frackowiak H., Jakubowski H.
Acta Scientiarum Polonorum. Medicina Veterinaria
|
2009
|
tom 08
|
nr 2
Analyses were conducted on 20 adult females of the raccoon dog (Nyctereutes procyonoides). The measurements allowed to calculate the mean length of the raccoon dog, amounting to 247.09 cm, and the mean total length of intestines, amounting to 207.83 cm. Mean values of individual intestinal fragments, i.e. duodenum, jejunum, ileum, caecum and colon with rectum amounted to 31.17, 170.00, 6.65, 8.04 and 31.22 cm, respectively. Jejunum had the highest (68.80%) and ileum the lowest (2.70%) share in the total length of intestines. The highest correlation coefficient characterized the relation­ship between total length of intestines and total length of small intestine.
19

Allometric analysis of cranial parameters of American mink, including bones of masticatory apparatus

51%
Jakubowski H., Komosa M., Frackowiak H.
Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine
|
2008
|
tom 11
|
nr 3
20

Dietary hyperhomocysteinemia reduces brain AQP4 expression and cognitive performance in old mice

51%
Suszynska-Zajczyk J., Sliwowska J., Jakubowski H.
Acta Neurobiologiae Experimentalis
|
2017
|
tom 77
|
nr Suppl.1
INTRODUCTION: Elevated plasma total homocysteine (tHcy), i.e. hyperhomocysteinemia (HHcy), is associated with brain pathologies such as vascular dementia, cognitive decline and Alzheimer’s disease and glial functions. Learning and memory may also be indirectly regulated by water homeostasis in the brain. AIM(S): Determine how the mouse brain and behaviour are affected by chronic long‑term dietary HHcy. METHOD(S): HHcy was induced in 8-month-old C57BL/6 male mice by providing 1% methionine in drinking water for 12 months. Control mice did not receive methionine. At 20 months of age, weight, urinary tHcy, and behavioural phenotypes were recorded. Cognitive impairment was assessed by the Novel Object Recognition (NOR) test. Mice were sacrificed, perfused, and brains were collected for aquaporin‑4 (AQP4) immunohistochemistry. RESULTS: HHcy mice had lower body weight than controls (31.4±1.1 vs. 35.1±1.3 g, p=0.04). HHcy mice had 32-fold higher urinary tHcy than controls (493±57 vs. 15.3±4.9 μM, p<0.0001). HHcy mice showed neurodegener ing and spatial orientation in Kcnb1 mutant embryos and larvae. RESULTS: The otic vesicle and otoliths of Kcnb1 mutant develop relatively normal. We observed significant length reduction of the otic vesicle in mutant embryos. Mutants demonstrate significant hearing defects and uncoordinated balance movements. CONCLUSIONS: Unlike clear morphological abnormality of the brain ventricular system, development of the otic vesicle in Kcnb1 zebrafish mutant is relatively uneventful. Kcnb1 requirement in the ear manifests itself in mutants as abnormal hearing and vestibular function. FINANCIAL SUPPORT: This work was supported by funds from OPUS grant to Vladimir Korzh from National Science Centre (OPUS UMO-2016/21/B/N23/00354).
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.