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1

Acid - base relations between cisternal fluid and arterial blood with reference to control of ventilation

100%
Pokorski M.
Acta Physiologica Polonica
|
1979
|
tom 30
|
nr 1
2

Efficient management in the construction industry under the current market

100%
Pokorski M.
World Scientific News
|
2019
|
tom 126
3

Changes in acid-base balance and breathing pattern after intracebrally injected ouabain in rabbits

100%
Pokorski M.
Acta Physiologica Polonica
|
1979
|
tom 30
|
nr 1
4

Acid base relations between arterial blood and cisternal fluid with reference to control of ventilation in rabbits

100%
Pokorski M.
Acta Physiologica Polonica
|
1980
|
tom 31
|
nr Supl.20[2]
5

Construction project management in Warsaw. Case study

88%
Pokorski M.
World Scientific News
|
2019
|
tom 129
6
Content available remote

Stability of ascorbyl palmitate molecule in the rat brain

63%
Pokorski M., Marczak M.
Journal of Physiology and Pharmacology. Supplement
|
2005
|
tom 56
|
nr 4
197-201
Recent investigations have shown the ability of ascorbyl palmitate (AP), a bioactive, lipid-soluble ester of ascorbic acid (AA), to penetrate neural tissues. This study seeks to determine the occurrence of hydrolysis of AP molecule in brain tissue, which could rather point to the action of AA alone carried over the biological barrier and then released from the AP compound. The integrity of AP molecule was examined qualitatively in the rat brain by thin-layer-chromatography. AP was injected into an internal carotid artery in a dose of 75 mg per rat after tying off the common and external carotid arteries at the same side. The rats were sacrificed 15 min later, the brain tissue was extracted with chloroform/methanol and chromatographed. The AP bands plated from the samples ispilateral to the injection side strictly corresponded to the AP standard's location and were clearly separated from the AA standard with no overlap. The experiment showed that AP resists hydrolysis in the brain and thus the short-term biological effects of AP may be ascribed to the action of an intact ester molecule. The results may help elucidate the biological action of AP, a compound that increasingly attracts attention for biomedical use due to its antioxidant potential and ability to penetrate into the membrane signaling target sites.
7

Wpływ Znieczulenia ogólnego na spontaniczne wychodzenie serca kota z migotania komór

63%
Pokorski M., Gromysz H.
Acta Physiologica Polonica
|
1971
|
tom 22
|
nr 3
8
Content available remote

Memory, depression, and progressing old age in women

63%
Pokorski M., Siwiec P.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 4
297-304
In this study we investigated the interrelationships among memory function, depression, and progressing age in the elderly women. We hypothesized that memory deficit would increase with progressing old age and would be further enhanced in the presence of depression. The study was conducted on 44 female volunteers of the mean age of 67.8 ±1.1(SE) years (range 55-83). The population sample was dichotomized into the depressed and non-depressed subgroups. All subjects were closely homogenous with respect to the post-menopausal status and general life factors. The methodology was based on a group survey in which The Center for Epidemiologic Studies Depression Scale questionnaire and a visual letter recall test were used for the assessment of depression and memory, respectively. The results failed to support the hypothesis. In the first place we found that the mean memory deficit was similar in both depressed and non-depressed subjects, amounting to about 40% of missed letters on recall. Memory deficit progressed with age only in the subgroup of depressed women, but rather surprisingly, it was not associated with the level of depression that actually declined with age in this subgroup. We conclude that progressing old age alone is not necessarily entwined with the intensification of either depression or memory decline. Depression is a factor in memory decline through brain mechanisms unrelated to the intensity of depressive symptoms.
9
Content available remote

Alterations in the hypoxic ventilatory response with advancing age in awake rats

63%
Pokorski M., Antosiewicz J.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 2
This study seeks to determine the influence of aging on hypoxic ventilatory responsiveness. We addressed the issue by comparing the hypoxic ventilatory responses in three age-groups of conscious rats: 3, 12, and 24 months old animals. Ventilation was recorded in a whole body rodent plethysmograph. Minute ventilation (E), respiratory rate, and tidal volume were considered for analysis. The rats were subjected to two levels of acute hypoxia: 14 and 11% O2 in N2. Hypoxic exposures were separated by a 15 min recovery interval in air. The part of the study between the 12 and 24 months age interval was longitudinal in that the same animals were studied twice, whereas the youngest animals belonged to a separate breed. All data were normalized to body mass. All hypoxic responses were biphasic with the stimulatory peak at 0.5 min after onset of hypoxia. The results demonstrate that there were no appreciable differences in magnitude of the peak hypoxic E responses between 3 and 12 months old rats. The hypoxic E responses and also the hypoxic ventilatory gain were, however, enhanced in the senescent rats. In these rats, the increment in peak E from 14 to 11% hypoxia amounted to 364.1±95.8 ml.min-1.kg-1, which was more than double compared with 12 and 3 months old rats (P<0.02). We conclude that ventilatory responsiveness is not curtailed in senescent rats. The respiratory system is able to compensate for any age-related handicaps in the respiratory system to maintain a stimulatory response to ventilatory stress.
10

Ultramikroelektrodowa metoda rejestracji potencjałów czynnościowych serca królika in situ

63%
Gromysz H., Pokorski M.
Acta Physiologica Polonica
|
1970
|
tom 21
|
nr 2
11
Content available remote

Depression and memory: a comparative study of young and old women

63%
Pokorski M., Siwiec P.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 6
573-578
12
Content available remote

Parental attitudes and social competence in adolescents

63%
Drozdz E., Pokorski M.
Journal of Physiology and Pharmacology. Supplement
|
2007
|
tom 58
|
nr 5
13

The effect of noradrenaline of respiration

63%
Pokorski M., Czyzowski M.
Acta Physiologica Polonica
|
1976
|
tom 27
|
nr 6
14
Content available remote

Ventilatory augmentation by acute intermittent hypoxia in the rabbit

63%
Sokolowska B., Pokorski M.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 4
341-347
This study seeks to determine the effects on respiratory function of acute intermittent hypoxia. The experiments were performed on anesthetized, spontaneously breathing rabbits. The experimental protocol consisted of 5 one-minute episodes of hypoxia (14% O2 in N2) interspersed with three-minute normoxic recovery periods. Ventilatory variables, minute ventilation (MV) and its tidal and frequency components, were derived from the continuously recorded airflow signal. We found that MV progressively increased with each next hypoxic-normoxic cycle; the increases were driven by both ventilatory components. Ventilatory augmentation concerned both the stimulus (hypoxic) and recovery (normoxic) periods, but it was significantly greater in the former. The augmented ventilation was sustained for up to 30 min after the last hypoxic run, which suggests the appearance of ventilatory long-term facilitation. The results demonstrate that acute intermittent hypoxia consisting of a few hypoxic-normoxic cycles is capable of inducing appreciable ventilatory changes. Such changes reflect plasticity of the respiratory motor output developing on a short-term basis during ongoing cycles of hypoxia, which, in the present study, correlated with the number of hypoxic cycle. Ventilatory augmentation in response to acute cyclic hypoxic episodes may give insights into the mechanisms of respiratory improvement by intermittent hypoxic training, increasingly used in both sports physiology and medicinal approaches.
15

The carotid body in the motoneuron response to large inspiration

63%
Jernajczyk U., Pokorski M.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
16

Decrease of oxygen difference between arterial blood and cerebrospinal fluid after interavenous injection of sodium bicarbonate in hyperoxic patients, anaesthetized, paralyzed and artifically ventilated

63%
Ryba M., Pokorski M.
Acta Physiologica Polonica
|
1981
|
tom 32
|
nr 5
17

Stability of N-oleoyl-dopamine

63%
Zajac D., Pokorski M.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr 1
N-oleoyl-dopamine (OLDA) is a newly discovered endogenous lipid derivative of dopamine. It acts in a dopamine-like manner by, e.g., diminishing the respiratory response to hypoxia, enhancing the locomotor activity of the rat, or relaxing muscles in a reserpine model of Parkinson,s disease. In the context of being a potential prodrug or dopamine carrier in Parkinson’s disease, the aim of our study was to establish OLDA’s penetration into the brain after systemic administration and its stability in both in vivo and in vitro conditions. Thin layer chromatography and UV/VIS spectrometry techniques were used. We found that OLDA penetrates after i.p. injections into the brain, where it binds to membranes and stays stable for at least 24 h. In inorganic buffers its stability is comparable with those of dopamine. However, in rat brain membrane solution, OLDA remains unchanged for 17 h; lack of calcium ions prolongs this period to 24 h. In cytosolic solutions, OLDA is stable for over 24 h, regardless of the presence of Ca ions. Additionally, an intact rat brain membrane system protects OLDA from oxidation. In conclusion, N-oleoyl-dopamine is a highly stable, blood-brainbarrier penetrating, bioactive compound. OLDA’s stability, penetration into the nervous tissue and dopamine-like actions suggest its being a potentially useful compound in treatment of diseases linked to central dopamine deficits.
18
Content available remote

Self-injuries in adolescents: social competence, emotional intelligence, and stigmatization

63%
Kulikowska A., Pokorski M.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 6
383-392
19

NADPH-diaphorase in the cat carotid body

63%
Walski M., Pokorski M.
Acta Neurobiologiae Experimentalis
|
2000
|
tom 60
|
nr 1
20
Content available remote

Oxygen breathing and ventilation

63%
Marczak M., Pokorski M.
Journal of Physiology and Pharmacology
|
2004
|
tom 55
|
nr 1,1
We investigated the ventilatory response to normobaric poikilocapnic hyperoxia in healthy subjects. The study was carried out in 26 subjects of the mean age 26 ±0.9 (SE) years, who breathed pure oxygen through a two-way valVE for 10 min. The subjects were in the sitting position with a mouthpiece and nose clip attached. Ventilatory flow was recorded using a pneumotachograph and minute ventilation was calculated from the tidal and frequency components. The SaO2 and alveolar CO2 tension were continuously monitored. Ten of the same subjects constituted a control group in which room air was substituted for oxygen and the tests repeated in the same way at another occasion. We found that oxygen breathing caused a transient 8.4% decline in ventilation, whose nadir was 1 min after the introduction of oxygen. Thereafter, ventilation increased significantly aboVE the baseline value and showed a further rising tendency toward the end of the test. We conclude that acute oxygen treatment is unlikely to haVE a major inhibitory effect on the carotid body-dependent ventilatory driVE in normal subjects. The determinants of the hyperoxic ventilatory stimulation remain to be established in further studies.
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