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1

The histology of pigmented Bomirski melanoma growing in the hamster eye - preliminary results

100%
Romanowska-Dixon B., Urbanska K., Elas M., Cichocki T.
Cellular and Molecular Biology Letters
|
2003
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tom 08
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nr 3
We demonstrated that a quickly growing hamster skin melanoma developed a tumor after autologous implantation into the anterior chamber of the eye. Tumor cells were seen invading all the surrounding tissues, including the iris, ciliary body, choroid and cornea. Histological examination confirmed the presence of numerous blood vessels of large diameter. Their walls were very thin, thus only the endothelium could be identified using light microscopy. Macrophages, microemboli and extravasations were present within the tumor mass.
2
Content available remote

Involvement of serum anti-retinal antibodies in the pathophysiology of diabetic retinopathy: a pilot study

88%
Weglarz M., Romanowska-Dixon B., Wilanska J., Sanak M., Karska-Basta I.
Journal of Physiology and Pharmacology
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2020
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tom 71
|
nr 5
3
Content available remote

Mydrane intracameral injection can be an alternative to mydriatic drops instillation in cataract surgery

88%
Nazim-Lipski G., Bolsega-Pacud J., Kubicka-Trzaska A., Markiewicz A., Romanowska-Dixon B.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 2
4
Content available remote

Non-responsiveness and tachyphylaxis to anti-vascular endothelial growth factor treatment in naive patients with exudative age-related macular degeneration

88%
Zuber-Laskawiec K., Kubicka-Trzaska A., Karska-Basta I., Pociej-Marciniak W., Romanowska-Dixon B.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 5
5
Content available remote

Central serous chorioretinopathy induced by drugs metabolized by cytochrome P450 3A4

88%
Morawski K., Klonowska A., Kubicka-Trzaska A., Woron J., Romanowska-Dixon B.
Journal of Physiology and Pharmacology
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2020
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tom 71
|
nr 2
6
Content available remote

Altered serum levels of autophagy proteins Beclin-1 and mTOR in patients with exudative age-related macular degeneration

76%
Kubicka-Trzaska A., Zuber-Laskawiec K., Plutecka H., Romanowska-Dixon B., Sanak M., Kraska-Basta I.
Journal of Physiology and Pharmacology
|
2021
|
tom 72
|
nr 1
7

Downregulation of polo-like kinase-1 (PLK-1) expression is associated with poor clinical outcome in uveal melanoma patients

76%
Berus T., Markiewicz A., Kobylinska K., Biecek P., Orlowska-Heitzman J., Romanowska-Dixon B., Donizy P.
Folia Histochemica et Cytobiologica
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2020
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tom 58
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nr 2
8

Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas

76%
Urbanska K., Romanowska-Dixon B., Matuszak Z., Oszajca J., Nowak-Sliwinska P., Stochel G.
Acta Biochimica Polonica
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2002
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tom 49
|
nr 2
Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatment of melanoma cells. Cytotoxicity of ICG itself and the effect of photodynamic therapy (PDT) were evaluated by following the growth of human (SKMEL 188) and mouse (S91) melanoma cells. The surviving fraction of the cells irradiated (λex = 830 nm) vs non-irradiated, treated with the same dose of ICG, is significantly decreased (5- to 10-fold). These results show that ICG is a very promising dye for photodynamic therapy of melanomas.
9

Metastasis inhibition after proton beam, beta- and gamma-irradiation of melanoma growing in the hamster eye

64%
Romanowska-Dixon B., Elas M., Swakon J., Sowa U., Ptaszkiewicz M., Szczygiel M., Krzykawska M., Olko P., Urbanska K.
Acta Biochimica Polonica
|
2013
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tom 60
|
nr 3
Standard ocular tumor treatment includes brachytherapy, as well as proton therapy, particularly for large melanoma tumors. However, the effects of different radiation types on the metastatic spread is not clear. We aimed at comparing ruthenium (106Ru, emitting β electrons) and iodine (125I, γ-radiation) brachytherapy and proton beam therapy of melanoma implanted into the hamster eye on development of spontaneous lung metastases. Tumors of Bomirski Hamster Melanoma (BHM) implanted into the anterior chamber of the hamster eye grew aggressively and completely filled the anterior chamber within 8-10 days. Metastases, mainly in the lung, were found in 100% of untreated animals 30 days after enucleation. Tumors were irradiated at a dose of 3-10 Gy with a 106Ru plaque and at a dose of 6-14 Gy using a 125I plaque. The protons were accelerated using the AIC-144 isochronous cyclotron operating at 60 MeV. BHM tumors located in the anterior chamber of the eye were irradiated with 10 Gy, for the depth of 3.88 mm. All radiation types caused inhibition of tumor growth by about 10 days. An increase in the number of metastases was observed for 3 Gy of β-irradiation, whereas at 10 Gy an inhibition of metastasis was found. γ-radiation reduced the metastatic mass at all applied doses, and proton beam therapy at 10 Gy also inhibited the metastastic spread. These results are discussed in the context of recent clinical and molecular data on radiation effects on metastasis.
10
Content available remote

Differences in anti-endothelial and anti-retinal antibody titers: implications for the pathophysiology of acute and chronic central serous chorioretinopathy

64%
Karska-Basta I., Pociej-Marciak W., Chrzaszcz M., Wilanska J., Jager M. J., Markiewicz A., Romanowska-Dixon B., Sanak M., Kubicka-Trzaska A.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 2
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