Wyniki wyszukiwania

1

Światłoczułe utlenianie niektórych 3-podstawowych pochodnych indolu w obecności riboflawiny

100%

Shugar D.

Acta Biochimica Polonica

|

1954

|

tom 01

|

nr 1-2

2

The NTP phosphate donor in kinase reactions: Is ATP a monopolist?

100%

Shugar D.

Acta Biochimica Polonica

|

1996

|

tom 43

|

nr 1

This brief overview describes some of the properties of various cellular phosphotransferase systems, with particular emphasis on nucleoside 5'-triphosphate (NTP)- dependent protein kinases and nucleoside kinases, for which it is widely and implicitly assumed that ATP is the intracellular phosphate donor. Numerous examples are presented, based on the in vitro properties of these enzymes, to show that ATP is not the only, or frequently not even the major, phosphate donor, and that this is probably reflected in vivo. It is pointed out that in vitro studies of donor and acceptor specificities of kinases must take account of the intracellular concentrations of nucleoside 5-triphosphates, a problem also relevant to the design of nucleoside analogues as chemotherapeutic agents. Attention is also drawn to NTP analogues as substrates/ inhibitors of protein kinases, and to several examples of low-molecular mass non- peptide substrates of these enzymes.

3

Purine nucleoside phosphorylases: properties, functions, and chemotherapeutic applications

100%

Shugar D.

Cellular and Molecular Biology Letters

|

1999

|

tom 04

|

nr 3

4

3rd Meeting of the Federation of European Biochemical Societies, Warsaw, April 4-7, 1966: some personal recollections

100%

Shugar D.

Acta Biochimica Polonica

|

2004

|

tom 51

|

nr 2

5

Protein kinase inhibitors - potential chemotherapeutic agents

100%

Shugar D.

Acta Biochimica Polonica

|

1995

|

tom 42

|

nr 4

Protein kinase inhibitors, widely exploited for elucidation of the biological functions of kinases, have more recently come under active consideration as potential chemotherapeutic agents for tumour and other diseases. A brief overview is presented of diverse approaches to the design and development of selective protein kinase inhibitors, and related problems such as donor and acceptor specificities, stereochemical aspects, emerging relationships between protein, sugar and nucleoside kinases. In particular, and contrary to popular belief that ATP-competitive inhibifcrs cannot be selective because of the close homology of the ATP catalytic sites, numerous examples are presented of such inhibitors which are both potent and selective for a given kinase or class of kinases. Some of these are undergoing preclinical trials. Attention is also directed to the role of cellular and viral protein kinases in the ljfe cycle of viruses, and the potential of these enzymes, especially those encoded by, and essential for replication of, a given virus as targets for antiviral chemotherapy.

6

Viral and host-cell protein kinases: enticing antiviral targets

100%

Shugar D.

Cellular and Molecular Biology Letters

|

1998

|

tom 03

|

nr 3

7

Preparation and properties of formycin analogues methylated on the pyrazolo ring nitrogens and/or the ribose cis-hydroxyls

64%

Giziewicz J., Shugar D.

Acta Biochimica Polonica

|

1977

|

tom 24

|

nr 3

8

Hydrogen bonding scheme involving ribose 2'-hydroxyls in polyribouridylic acid

64%

Rabczenko A., Shugar D.

Acta Biochimica Polonica

|

1972

|

tom 19

|

nr 1

9

Intermediates in the synthesis of purines and pteridines: N-methylated 6-chlorouracils

64%

Kazimierczuk Z., Shugar D.

Acta Biochimica Polonica

|

1970

|

tom 17

|

nr 4

10

The preparation and properties of high molecular weight polymers of N-methyluridylic acid

64%

Szer W., Shugar D.

Acta Biochimica Polonica

|

1961

|

tom 08

|

nr 2

11

Properties of poly-xanthylic acid and its reactions with potentially complementary homopolynucleotides

64%

Fikus M., Shugar D.

Acta Biochimica Polonica

|

1969

|

tom 16

|

nr 1

12

Photochemistry of 5-ethyluracil and its glycosides

64%

Pietrzykowska I., Shugar D.

Acta Biochimica Polonica

|

1970

|

tom 17

|

nr 4

13

Influence of gamma-irradiation on liver regeneration in normal and starved rats

64%

Janion C., Shugar D.

Acta Biochimica Polonica

|

1962

|

tom 09

|

nr 3

14

Mutagenicity of hydroxylamine: reaction with analogues of cytosine, 5(6)-substituted cytosines and some 2-keto-4-ethoxypyrimidines

64%

Janion C., Shugar D.

Acta Biochimica Polonica

|

1965

|

tom 12

|

nr 4

15

A note on the stability of pyrimidine nucleoside cyclic phosphate methyl esters and the mode of action of ribonuclease

64%

Szer W., Shugar D.

Acta Biochimica Polonica

|

1962

|

tom 09

|

nr 2

16

The role of proteins in, and the question of localization of the gram reaction

64%

Baranowska J., Shugar D.

Acta Microbiologica Polonica

|

1957

|

tom 06

|

nr 2

17

Rola białek w metodyce i w lokalizacjii barwienia gramem drobnoustrojów

64%

Baranowska J., Shugar D.

Acta Microbiologica Polonica

|

1956

|

tom 05

|

nr 1-2

18

Preparation and chemical and enzymic properties of cyclic phosphates of D-glucopyranose and synthesis of derivatives of N-(D-glucopyranosyl) pyridine

64%

Zmudzka B., Shugar D.

Acta Biochimica Polonica

|

1964

|

tom 11

|

nr 4

19

Studies on the conformation of nucleosides, dinucleoside monophosphates and homopolynucleotides containing uracil or thymine base residues, and ribose, deoxyribose or 2'-O-methylribose

64%

Rabczenko A., Shugar D.

Acta Biochimica Polonica

|

1971

|

tom 18

|

nr 4

20

Thymidine phosphorylase and other enzymes in regenerating rat liver

64%

Janion C., Shugar D.

Acta Biochimica Polonica

|

1961

|

tom 08

|

nr 3

Ograniczanie wyników

Światłoczułe utlenianie niektórych 3-podstawowych pochodnych indolu w obecności riboflawiny

The NTP phosphate donor in kinase reactions: Is ATP a monopolist?

Purine nucleoside phosphorylases: properties, functions, and chemotherapeutic applications

3rd Meeting of the Federation of European Biochemical Societies, Warsaw, April 4-7, 1966: some personal recollections

Protein kinase inhibitors - potential chemotherapeutic agents

Viral and host-cell protein kinases: enticing antiviral targets

Preparation and properties of formycin analogues methylated on the pyrazolo ring nitrogens and/or the ribose cis-hydroxyls

Hydrogen bonding scheme involving ribose 2'-hydroxyls in polyribouridylic acid

Intermediates in the synthesis of purines and pteridines: N-methylated 6-chlorouracils

The preparation and properties of high molecular weight polymers of N-methyluridylic acid

Properties of poly-xanthylic acid and its reactions with potentially complementary homopolynucleotides

Photochemistry of 5-ethyluracil and its glycosides