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1
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Spektrofotometryczne oznaczanie trimetoprimu w osoczu i krwi ludzi

100%
Klimowicz A.
Diagnostyka Laboratoryjna
|
1981
|
tom 17
|
nr 1
2
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Spektrofotometryczna metoda oznaczania stężenia sulfonamidów aktywnych

100%
Klimowicz A.
Diagnostyka Laboratoryjna
|
1986
|
tom 22
|
nr 4-5
3

Zdrowotne oddziaływanie polifenoli zielonej herbaty (Camellia sinensis L.)

63%
Nowak A., Klimowicz A.
Kosmos
|
2013
|
tom 62
|
nr 1
4

Ocena stosowania substancji przeciwdrobnoustrojowych u świń i bydła w Polsce na podstawie badań sondażowych w 2010 roku

51%
Krasucka D., Cybulski W., Klimowicz A.
Medycyna Weterynaryjna
|
2012
|
tom 68
|
nr 02
The European Medicines Agency (EMA) obliges EU members to report of on sales/distribution of veterinary medicinal products (VMP) at a national level. In addition to this mandatory route, a research project based on a questionnaire of 109 practitioner veterinarians representing all regions of Poland has been carried out. The results of statistical analysis of antimicrobial agents used by the probed veterinarians to treat swine and cattle have been completed for 2010. The data were expressed according to recommendations of EMA as the weight mass of pharmacologically active substances within the antibiotic groups. The responder reports placed the tetracycline group as the most frequent agent used in the swine treatments; weight amounts scored 49.1% of total antimicrobials. The penicillin group amounted to 25.7%, followed by macrolides (8.1%) and sulfonamides (5.9%). Aminoglicosides, pleuromutylines and fluoroquinolones usage numbered 3.0%, 2.95% and 2.8%, respectively. Whereas in cattle the prevalence was of penicillins (35.2%), followed by sulfonamides (33.5%), tetracycline (15.9%), aminoglicoside (9.6%), fluoroquinolone (3.5%) and macrolide (1.5%) were recorded. A similar trend of antimicrobial agents consumption was observed in statistics from the countries neighboring Poland in the south; however, when compared to Scandinavia countries it differed. Analysis of the data for antimicrobial agents make it possible to evaluate the prudent use of antibiotics and sulfonamides in Poland. In case of fluoroquinolone, the low figures situated this group in the second line order of antibiotics administered to swine, since they were used as the fifth group of antimicrobials in cattle.
5

Porównawcza analiza stosowania leków przeciwdrobnoustrojowych u trzody chlewnej w Polsce w 2010 i 2011 r.

51%
Krasucka D., Cybulski W., Klimowicz A.
Magazyn Weterynaryjny
|
2012
|
tom 21
|
nr 06 Choroby Świń - Monografia
6
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The impact of plant material freezing and extractant acidifying on the antioxidant potential and pigments content in extracts and raw materials of different carrot varieties

51%
Muzykiewicz-Szymanska A., Zielonka-Brzezicka J., Klimowicz A.
Acta Scientiarum Polonorum. Hortorum Cultus
|
2021
|
tom 20
|
nr 2
7

Skuteczność Apiwarolu AS w latach 1981-2009

51%
Dzierzawski A., Cybulski W., Krasucka D., Klimowicz A.
Pszczelarstwo
|
2011
|
tom 62
|
nr 02
8

Tendencje stosowania antybiotyków u bydła w okrasie zasuszania i laktacji w latach 2010-2012

51%
Krasucka D., Cybulski W., Klimowicz A.
Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii
|
2013
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tom 08
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nr 2 Monografia
9

Analiza stosowania antybiotyków i sulfonamidów u bydła. Odniesienia do chorób układu oddechowego i pokarmowego (biegunki)

51%
Krasucka D., Cybulski W., Klimowicz A.
Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii
|
2011
|
tom 06
|
nr 2 Monografia
10

Antybiotyki stosowane w lecznictwie weterynaryjnym bydła w Polsce w latach 2010 - 2011 rosnący udział sulfonamidów i cefalosporyn

51%
Krasucka D., Cybulski W., Klimowicz A.
Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii
|
2012
|
tom 07
|
nr 2 Monografia
11
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Quince (Cydonia oblonga Mill.) as a useful source of antioxidants – antioxidant activity evaluation

51%
Muzykiewicz A., Zielonka-Brzezicka J., Klimowicz A.
Herba Polonica
|
2018
|
tom 64
|
nr 4
Introduction: Quince (Cydonia oblonga Mill.) is a plant of which both the fruits and the leaves are sources of compounds with antioxidant potential. Such activity could be helpful to prevent the development of socalled oxidative stress. Objective: The aim of the study was to evaluate the antioxidant properties of ethanolic, methanolic and acetonic extracts of mature and immature quince fruits, as well as leaves. Methods: The extracts were prepared using ultrasound-assisted extraction, for 15, 30 and 60 minutes. The antioxidant activity was assessed by DPPH, FRAP, ABTS and Folin-Ciocalteu (F-C) methods. Results: Antioxidant activity of all of the evaluated extracts were observed. The highest potential determined with each method was found for leaf extracts. Moreover, higher activity of unripe fruit extracts compared to ripe fruit was observed. Taking into account the applied extractants, the highest antioxidant capacity was found for methanolic extracts, extracted for 60 and 30 minutes. By contrast, the lowest potential was observed mainly for ethanolic extracts (extraction time 15 minutes). Conclusion: Quince extracts, particularly alcoholic extracts of leaves, seem to be a valuable source of antioxidants. Factors as extraction time, the type of solvent and degree of fruit maturity may influence the antioxidant activity of extracts.
12

Antioxidant activity of various plant sprouts extracts depending on the processing method of plant material – an in vitro study

51%
Muzykiewicz-Szymanska A., Zielonka-Brzezicka J., Siemak J., Klimowicz A.
Herba Polonica
|
2020
|
tom 66
|
nr 2
13
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Antioxidant potential of Hippophae rhamnoides L. extracts obtained with green extraction technique

51%
Muzykiewicz A., Zielonka- Brzezicka J., Klimowicz A.
Herba Polonica
|
2018
|
tom 64
|
nr 4
Introduction: Antioxidants, isolated from different plant parts, are widely used due to their ability to prevent the development of so-called oxidative stress. Sea buckthorn (Hippophae rhamnoides L.) is one of the plants with expected antioxidant properties. Objective: The aim of the study was to evaluate the antioxidant activity of ethanolic, methanolic and acetonic extracts of H. rhamnoides leaves, ripe and unripe fruits obtained by ultrasound-assisted extraction. Methods: To estimate the antioxidant potential of the extracts the DPPH, FRAP, ABTS and Folin-Ciocalteu methods were applied. Moreover, the influence of the extrahent, as well as extraction time, on this activity was evaluated. Results: Sea buckthorn leaf extracts showed higher activity, contrary to the fruit extracts. Moreover, higher activity of ripe fruit extracts compared to unripe material extracts was found. To obtain the highest content of antioxidants in the extracts, ultrasound-assisted extraction for 60 min with methanol should be applied. Conclusions: The presented in vitro results could lead to the conclusion that H. rhamnoides seems to be a valuable source of antioxidants to be applied in various branches of industry.
14
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Comparison of antioxidant activity of extracts of hop leaves harvested in different years

39%
Muzykiewicz A., Nowak A., Zielonka-Brzezicka J., Florkowska K., Duchnik W., Klimowicz A.
Herba Polonica
|
2019
|
tom 65
|
nr 3
15

Poultry vaccines available on the Polish market after the harmonization of pharmaceutical code according to EU legislation - analysis of trends at domestic versus global scale

33%
Cybulski W., Pasik K., Krasucka D., Lysiak E., Mitura A., Klimowicz A., Tomczyk G., Pietron W.
Medycyna Weterynaryjna
|
2015
|
tom 71
|
nr 05
Poland’s accession to the European Union (EU) has entailed the implementation of mutual recognition procedures for the authorization of immunological veterinary medicinal products (IVMPs) since 2009. The aim of the study was to analyse data on the assortment and number of doses in the batches of vaccines for poultry authorized on the Polish market in 2010. These data, compared with the total output of doses in the same batches of IVMPs manufactured worldwide, revealed trends in the application of poultry vaccines in Poland. The results of the survey indicate that poultry IVMPs were the most important immunologicals on the Polish market in terms of variety and the numbers of doses. The dominant position of poultry IVMPs against viral diseases on the Polish market reflected the global trend. They accounted for 97.98% of all poultry IVMPs, followed by anti-bacterial (1.55%) and anti-parasitic IVMPs (0.47%). The order of the five most popular poultry IVMPs was the same on the Polish market as in the global markets, namely vaccines against IB, IBD, ND, MD and TRT. In contrast, anti-bacterial vaccines against Salmonellosis (SE and ST) took the 8th place in terms of their share of the total number of doses manufactured and sold on the Polish market, whereas the total number of doses manufactured globally situated them at the 15th place. Moreover, the position of some anti-viral vaccines was substantially different in Poland; namely relatively high dose counts in vaccines against MD, TRT, DD and SHS, as opposed to rather low shares of vaccine doses against AE, AP, ILT from what these were on the global market. In conclusion, these differences require thorough analysis and the recognition of trends in supply and demand terms accordingly sustainable vaccination programming. The findings might reveal a gap between immunoprophylaxis guidelines and current immunoprophylaxis needs relevant to epidemiological status of poultry flocks in Poland.
16
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The penetration of topically applied ointment containing hyaluronic acid in rabbit tissues

33%
Birkenfeld B., Parafiniuk M., Bielecka-Grzela S., Klimowicz A., Piwowarska-Bilska H., Mikolajczak R., Listewnik M. H., Kurzejamska-Parafiniuk M., Osowski A., Byszewska-Szpocinska E.
Polish Journal of Veterinary Sciences
|
2011
|
tom 14
|
nr 4
The properties of hyaluronic acid used for treatment of acute and chronic joint disease are known for many years and this compound is widely used both in humans and animals. To obtain a therapeutic effect of a certain drug, the appropriate concentration in the target organ or tissue is important. The application of labeled compounds is one of the frequently applied techniques to estimate drug penetration into the skin and other body tissues or organs. The aim of the study was to evaluate the penetration of hyaluronic acid labeled with I-131 through the skin and its distribution within the knee joint and other internal organs in rabbits after a topical application of an ointment containing hyaluronic acid.The experiment was performed on 22 albino rabbits divided into control and examined groups. Fifteen rabbits were exposed to the multicomponent ointment containing hyaluronic acid labeled with I-131. Time of exposure was 48 hours. Hyaluronate penetrated to a high degree into the examined tissues. No significant differences in terms of leg tissue activity were observed between a leg tissue exposed to labeled ointment and that unexposed, suggesting that after topical administration, the active component of the ointment is delivered to the joint via the blood stream. Hyaluronate applied topically penetrates through the skin into the rabbit tissues and organs and into the joint fluid of both legs (exposed and not exposed). This route of administration seems to be useful for this drug delivery and allows to avoid unnecessary side effects.
17
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Application of green-extraction technique to evaluate of antioxidative capacity of wild population of fireweed (Epilobium angustifolium)

33%
Nowak A., Klimowicz A., Duchnik W., Kucharski L., Florkowska K., Muzykiewicz A., Wira D., Zielonka-Brzezicka J., Siedlowska A., Nadarzewska K.
Herba Polonica
|
2019
|
tom 65
|
nr 4
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