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Arachidonic acid-induced apoptosis in rat hepatoma AS-30D cells is mediated by reactive oxygen species

100%

Dymkowska D., Wojtczak L.

Acta Biochimica Polonica

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2009

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tom 56

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nr 4

711-715

Arachidonic acid at micromolar concentrations produced a drastic increase of the generation of reactive oxygen species (ROS) in rat hepatoma AS-30D cells cultivated in vitro along with an increase in the incidence of apoptotic cell death. Both processes were prevented by trolox, a water-soluble tocopherol derivative, and tempol, a known antioxidative agent. A synthetic hybrid of lipoic acid and trolox or preincubation with N-acetylcysteine were less effective. Preincubation of the cells with etomoxir, a known highly specific irreversible inhibitor of carnitine-palmitoyltransferase I, partly decreased the ROS formation induced by arachidonic acid but it did not affect the increase in apoptosis. Cumulatively, these results indicate that apoptosis induced in hepatoma cells by arachidonic acid is mediated by ROS. They also suggest that this effect is due to arachidonic acid as such and not to its mitochondrial oxidative metabolites.

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Nonesterified fatty acids as protonophores and openers of mitochondrial permeability transition pore

100%

Dymkowska D., Wojtczak L.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

3

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Wpływ glinu na aktywność niektórych enzymów oraz poziom wapnia i kreatyniny w surowicy zwierząt doświadczalnych

61%

Aleksandrowicz J., Fiejka M., Slowikowska M., Slaski J., Graczyk A., Anczewska I., Dymkowska D.

Roczniki Państwowego Zakładu Higieny

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1993

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tom 44

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nr 1

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Roczniki Państwowego Zakładu Higieny

3 Dymkowska D.

2 Wojtczak L.

1 Aleksandrowicz J.

1 Anczewska I.

1 Fiejka M.

1 Graczyk A.

1 Slaski J.

1 Slowikowska M.

1 2009

1 2003

1 1993

Arachidonic acid-induced apoptosis in rat hepatoma AS-30D cells is mediated by reactive oxygen species

Nonesterified fatty acids as protonophores and openers of mitochondrial permeability transition pore

Wpływ glinu na aktywność niektórych enzymów oraz poziom wapnia i kreatyniny w surowicy zwierząt doświadczalnych