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  1. 19 Herba Polonica

  2. 2 Bromatologia i Chemia Toksykologiczna

  3. 1 Acta Agrophysica

  4. 1 Acta Biochimica Polonica

  5. 1 Acta Poloniae Toxicologica

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Autorzy help

  1. 30 Czerny B.

  2. 17 Bogacz A.

  3. 14 Mrozikiewicz P. M.

  4. 11 Karasiewicz M.

  5. 8 Bartkowiak-Wieczorek J.

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  1. 1 2020

  2. 2 2019

  3. 1 2018

  4. 2 2016

  5. 7 2013

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1
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Projektowany system melioracji w dolinie Górnej Narwi

100%
Czerny B., Oledzki S.
Zeszyty Problemowe Postępów Nauk Rolniczych
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1973
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tom 134
2

The influence of essential phospholipids [EPL] and allicin on lipid metabolism in man

100%
Samochowiec J., Czerny B.
Herba Polonica
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1997
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tom 43
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nr 1
53-57
Allicyna i niezbędne fosfolipidy okazały się bardziej efektywne w leczeniu hiperlipidemii aniżeli allicyna stosowana samodzielnie. Leczenie przeprowadzone u 100 pacjentów o średnim wieku 51.2 lat z ogólnym rozpoznaniem miażdżycy, miokardiopatii miażdżycowej oraz chromania przestankowego w stadium II wg Fontaina. Przedyskutowano działanie bezpośrednio obniżające poziom lipidów, jak też funkcję fosfolipidów jako nośnika allicyny.
3
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Wplyw temperatury i bakterii glebowych na odbudowe ukladu odpornosciowego i reprodukcje dzdzownic

81%
Olchawa E., Czerny B., Plytycz B.
Acta Agrophysica
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2003
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tom 01
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nr 4[89]
705-710
4

Wplyw selenu na zawartosc fluorkow w surowicy zwierzat

81%
Seglecka M., Put A., Czerny B.
Bromatologia i Chemia Toksykologiczna
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1998
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tom 31
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nr 2
173-175
Szczury samce szczepu Wistar karmiono dietą standardową z dodatkiem fluoru w postaci NaF „in substantia" w dawce 20 mg/kg m.c. przez 3 mies. Część zwierząt otrzymywała ponadto selenin sodowy (Na2SeO3) w dawce odpowiadającej 5 µg Se/kg m.c. Stwierdzono obniżenie zawartości fluorków w surowicy przy równoczesnym stosowaniu seleninu sodowego.
5

The influence of quercetin on some biochemical parameters in rats exposed to environmental contamination with fluorine compounds

81%
Czerny B., Put A., Mysliwiec Z., Juzyszyn Z.
Polish Journal of Environmental Studies
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2000
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tom 09
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nr 3
Male Wistar rats were exposed for 3 and 6 months to NH4F in a toxicological chamber. Some animals received sodium salts of quercetin sulfonic acids at a dose of 5 or 20 mg/kg body weight. It was found that quercetin alleviates biochemical changes in the liver caused by ammonium fluoride, in particular concerning enzyme activities and lipid metabolism.
6

Effect of tamoxifen on morphology and activity of oxidative enzymes in the liver, stomach, and kidneys of rats

81%
Kuzna-Grygiel W., Kolodziejczyk L., Czerny B., Put A.
Acta Poloniae Toxicologica
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2000
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tom 08
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nr 2
7

Wplyw chryzyny na wybrane wskazniki funkcji watroby w przebiegu podprzewleklego zatrucia fluorkiem sodowym u szczurow

71%
Mysliwiec Z., Czerny B., Juzwiak S., Juzyszyn Z., Musial H. D.
Bromatologia i Chemia Toksykologiczna
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2001
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tom 34
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nr 2
155-158
Szczurom samcom szczepu Wistar podawano przez trzy miesiące fluorek sodu o stęż. 100 mg F-/dm3 wody. Część szczurów otrzymywała dodatkowo chryzynę p.o. w dawkach 10 mg/kg m.c./24 godz. oraz 20 mg/kg m.c./24 godz. Stwierdzono, te podawanie chryzyny łagodzi zaburzenia aktywności enzymów w surowicy krwi wywołane działaniem fluorku sodu.
8
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Influence of Epilobium angustifolium extract on 5alpha-reductase type 2 and MAPK3 kinase gene expression in rats prostates

61%
Kujawski R., Bartkowiak-Wieczorek J., Karasiewicz M., Bogacz A., Mikolajczak P. L., Czerny B., Mrozikiewicz P. M.
Herba Polonica
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2013
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tom 59
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nr 4
The aim of this study was to investigate the influence of standardized Epilobium angustifolium L. extract [100 mg/kg/day, p.o.] on the expression level of 5α-reductase type 2 (Srd5ar2) mRNA and Mapk3 mRNA a representative of non-genomic xenobiotics signaling pathway. It was shown that plant extract from the E. angustifolium showed a slight tendency to reduce prostate weight in hormonally induced animals (p>0.05) and in testosterone induced animals receiving both, extract and finasteride (p<0.05). Finasteride in rats induced by testosterone caused a smaller decrease in the level of mRNA 5α-steroid reductase 2 (SRd5ar2), than in rats treated with the hormone and studied plant extracts. In general, an increase in the amount of MAPK3 mRNAs in testosterone-induced groups of rats receiving tested plant extract with or without finasteride was observed, while the expression of type 2 5α-steroid reductase decreased (p<0.05). Further experimental studies should be performed in order to understand the molecular basis of interactions, the efficacy and safety of tested plant extracts.
9
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Comparison of proanthocyanidins content in Rhodiola kirilowii and Rhodiola rosea roots - application of UPLC-MS/MS method

61%
Gryszczynska A., Krajewska-Patan A., Buchwald W., Czerny B., Mielcarek S., Rudzinska K., Mroziewicz P. M.
Herba Polonica
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2012
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tom 58
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nr 3
The purpose of presented study was the comparison of flavan-3-ol content in the roots of Rhodiola kirilowii and Rhodiola rosea with use of UPLC-MS/MS method. Two kinds of extract were prepared: aqueous extract and 50% v/v ethanol extract. The worked out UPLC MS/MS method allowed to determine the content of five flavan-3-ols: (+)-catechin, (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG). The obtained results shown that the content of measured catechins was higher in R. kirilowii roots than in R. rosea. Both Rhodiola roots contain EGCG as a main proanthocyanidin compound – the content in R. kirilowii roots is about 0.14%. Our results indicate that application of ultra performance liquid chromatograph connected to a tandem mass spectrometer (UPLC MS/MS method) allows to determine the proanthocyanidins content in tested samples with satisfactory precision and can be used in the Rhodiola sp. phytochemical investigations.
10
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SRC kinase mRNA transcription changes in testosterone-induced rat ventral prostate lobes under the influence of Epilobium angustifolium extract

61%
Kujawski R., Bartkowiak-Wieczorek J., Bogacz A., Karasiewicz M., Mikolajczak P. L., Czerny B., Mrozikiewicz P. M.
Herba Polonica
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2013
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tom 59
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nr 4
The aim of this study was to investigate the influence of standardized crude aqueous Epilobium angustifolium L. extract [100 mg/kg/day, p.o.] on the expression level of SRC kinase mRNA - a representatives of non-genomics xenobiotics signaling pathway in prostate ventral lobes of testosterone-induced, castrated rats. We have shown that in all analyzed groups induced by testosterone an elevation of SRC kinase mRNA transcription was observed, in comparison to control animals (not receiving the testosterone), (p<0.05). Finasteride in rats induced by testosterone caused the strongest inhibition of SRC mRNA transcription (p<0.05). In rats receiving testosterone and the plant extract a ca. 90% decrease of mRNA level was observed vs. testosterone-induced animals (p<0.05), while in testosterone-induced animals receiving concomitantly E. angustifolium extract and finasteride the observed reduction reached 87.3% (p<0.05). We did not observed, however, any positive feedback between studied plant extract and finasteride in the inhibitory activity (p<0.05). Further experimental studies should be performed in order to the understanding the molecular basis of interactions, the efficacy and safety of tested plant extract.
11
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Impact of Curcuma longa extract on the expression level of brain transporters in in vivo model

61%
Bukowska M., Bogacz A., Wolek M., Mikolajczak P. L., Olbromski P., Kaminski A., Czerny B.
Herba Polonica
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2019
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tom 65
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nr 1
Introduction: Blood brain barrier and multidrug resistance phenomenon are subjects of many investigations. Mainly, because of their functions in protecting the central nervous system (CNS) by blocking the delivery of toxic substances to the brain. This special function has some disadvantages, like drug delivery to the brain in neurodegenerative diseases. Objective: The aim of this study was to examine how natural and synthetic substances affect the expression levels of genes (Mdr1a, Mdr1b, Mrp1, Mrp2, Oatp1a4, Oatp1a5 and Oatp1c1) that encode transporters in the blood-brain barrier. Methods: cDNA was synthesized from total RNA isolated from rat hippocampus. The expression level of genes was determined using real-time PCR (RT-PCR) method. Results: Our findings showed that verapamil, as a synthetic substance, caused the greatest reduction of mRNA level of genes studied. The standardized extract of Curcuma longa reduced the expression level for Mrp1 and Mrp2, whereas the increase of mRNA level was observed for Mdr1b, Oatp1a5 and Oatp1c1. Conclusions: These results suggests that herbal extracts may play an important role in overcoming the blood brain barrier during pharmacotherapy
12
Content available remote

The influence of the tumor necrosis factor-alpha-308G>A polymorphism on the efficacy of immunosuppressive therapy in patients after kidney transplantation

52%
Kotowski M., Bogacz A., Bartkowiak-Wieczorek J., Sienko J., Procyk D., Dziewanowski K., Ostrowski M., Czerny B., Grzeskowiak E., Machalinski B.
Journal of Physiology and Pharmacology
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2016
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tom 67
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nr 6
13
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The effect of herbal materials on the P-glycoprotein activity and function

52%
Bogacz A., Deka-Pawlik D., Bartkowiak-Wieczorek J., Karasiewicz M., Kujawski R., Kowalska A., Chalas A., Czerny B., Grzeskowiak E., Mrozikiewicz P. M.
Herba Polonica
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2013
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tom 59
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nr 4
P-glycoprotein (P-gp) encoded by the MDR1 (multidrug resistance 1) gene is ATP-dependent transporting protein which is localizated in the cell membrane. P-gp is expressed Review Article 130 A. Bogacz, D. Deka-Pawlik, J. Bartkowiak-Wieczorek, M. Karasiewicz, R. Kujawski, A. Kowalska, A. Chałas, B. Czerny, E. Grześkowiak, P. M. Mrozikiewicz mainly in organs with the secretory functions and its physiological role concerns tissue protection against xenobiotics. P-glycoprotein is involved in the permeability barriers of the blood-brain, blood-placenta directly protecting these organs. It participates in the transport of many drugs and other xenobiotics affecting their absorption, distribution, metabolism and excretion. The high P-gp activity in the cell membranes of cancer tissue is a major cause of lack of effectiveness of chemotherapy. Hence, the methods which could increase the sensibility of these pathological cells to cytostatics are still being searched. In the experimental studies it was shown that natural plant substances may have an effect on the expression level and activity of P-glycoprotein. Hypericum perforatum, Ginkgo biloba and Camellia sinensis increase P-gp activity while curcumin from Curcuma longa, piperine and silymarin inhibit this protein. Taking into account a wide substrate spectrum of P-gp, application of our knowledge on interactions of herbals and synthetic drugs should be considered in order to improve drug impact on different tissues.
14

An optimization of hematopoietic stem and progenitor cell isolation for scientific and clinical purposes by the application of a new parameter determining the hematopoietic graft efficacy

52%
Baumert B., Grymula K., Pietruszka D., Kotowski M., Mielczarek M., Dziedziejko V., Halasa M., Czerny B., Walczak M., Machalinski B.
Folia Histochemica et Cytobiologica
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2008
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tom 46
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nr 3
299-305
15
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Impact of Panax ginseng and Ginkgo biloba extracts on expression level of transcriptional factors and xenobiotic-metabolizing cytochrome P450 enzymes

52%
Bogacz A., Karasiewicz M., Dziekan K., Procyk D., Gorska-Paukszta M., Kowalska A., Mikolajczak P. L., Ozarowski M., Czerny B.
Herba Polonica
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2016
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tom 62
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nr 1
Introduction: Despite widespread use of Panax ginseng and Ginkgo biloba, the data on the safety as well as herb-drug interactions are very limited. Therefore, we postulate that P. ginseng and G. biloba may modulate the activity and content of cytochrome P450 isozymes involved in the biotransformation of diverse xenobiotic substances. Objective: The aim of our study was to determine the influence of herbal remedies on the expression level of CYP enzymes and transcriptional factors. Methods: Male Wistar rats were given standardized Panax ginseng (30 mg/kg p.o.) or standardized Ginkgo biloba (200 mg/kg p.o.) for 3 and 10 days. The expression in liver tissue was analyzed by realtime PCR method. Results: Our results showed a decrease of CYP3A1 (homologue to human CYP3A4) mRNA level after P. ginseng extract treatment. The CYP2C6 (homologue to human CYP2C9) expression was also reduced. Additionally, after 10 days of the treatment with P. ginseng an increase of CYP1A1 (homologue to human CYP1A1) and CYP1A2 (homologue to human CYP1A2) expression was observed. Moreover, G. biloba extract also caused an increase of expression level for CYP1A1, CYP2C6, CYP3A1 and CYP3A2. Conclusion: Our findings suggest that herbal extracts can modulate the expression of transcriptional factors and CYP enzymes involved in xenobiotic metabolism and chemical carcinogenesis.
16

Polymorphism analysis of the Gly972Arg IRS-1 and Gly1057Asp IRS-2 genes in obese pregnant women

52%
Gorska A., Wolek M., Czerny B., Uzar I., Seremak-Mrozikiewicz A., Olbromski P., Baraniak J., Kania-Dobrowolska M., Sienko M., Bogacz A.
Reproductive Biology
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2020
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tom 20
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nr 3
17
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Current knowledge on phytochemical profile of Epilobium sp.raw materials and extracts. Potential benefits in nutrition and phytotherapy of age-related diseases

52%
Kujawski R., Bartkowiak-Wieczorek J., Ożarowski M., Bogacz A., Cichocka J., Karasiewicz M., Czerny B., Mrozikiewicz P. M.
Herba Polonica
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2011
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tom 57
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nr 4
As a consequence of ageing of populations and increase of life expectancy a growing interest in searching novel, safe and effective food preparations, plant origin dietary supplements or plant derived drugs, containing numerous substances that may counteract the emergence of age related disorders is observed. A clearly visible example of searching abovementioned herbal preparations is a growing interest among men suffering for urogenital disorders on preparations based in herbal plants such as: Serrenoa repens, Pygeum africanum, Urtica dioica, Cucurbita pepo, Hypoxis rooperi, Secale cereale, Zea mays. In recent years dietary supplements based on Epilobium genus representatives became very popular among patients with lower urinary tract symptoms (LUTS) and suffering for benign prostate hyperplasia (BPH). For the confirmation or justification of the use of preparations based on Epilobium sp. in folk medicine or diet supplementation we summarized the current knowledge on biological activities of herbal extracts and oils derived from this genus and variations of phytochemical compositions. The literature analysis reveals that herb was the substance most often subjected to phytochemical analysis (leaves or stems), the next one was seed oil of Epilobiium sp. representatives. In extracts from herb flavonoids (flavonol 3-O-glycosides based on kaempferol, quercetin, myricetin or guaiaverin aglycones), tannins (macrocyclic ellagitannins – oenothein A and B) and trace amounts of sterols as well as fatty acids were identified, while in extracts from seed oil sterols (β-sitosterol, kaempesterol, stigmasterol and brassicasterol) and fatty acids (mainly stearic, palmitic, oleic, linoleic, linolenic and caproic) were most often present. The conclusions of this paper may be helpful in further extensive research concerning the evaluation the effectiveness and safety of preparations based on the basis of Epilobium sp. and Onagraceae family representatives. A knowledge of bioactive compounds in Epilobium sp. could be especially needed in designing new, safe and effective formulations of nutriceuticals and phytotherapeutics containing medicinal parts of these plants.
18

Nowe spojrzenie na mechanizmy działania tradycyjnych mieszanek ziołowych stosowanych w leczeniu dolegliwości bólowych dolnego odcinka kręgosłupa

52%
Majchrzycki M., Mscisz A., Stryla W., Czerny B., Bogacz A., Karasiewicz M., Krajewska-Patan A., Grzeskowiak E., Mrozikiewicz P. M.
Herba Polonica
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2009
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tom 55
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nr 4
Ból pleców stanowi poważny problem współczesnej medycyny. Dolegliwości bólowe lędźwiowo-krzyżowego odcinka kręgosłupa są uwarunkowane wieloczynnikowo. Leczenie pacjentów cierpiących na to schorzenie powinno być kompleksowe i opierać się na rehabilitacji ruchowej i farmakoterapii. W ostatnich latach coraz częściej w celach łagodzenia bólu wykorzystywana jest również fitoterapia. Temat ten stanowi przedmiot intensywnych badań biochemicznych mających na celu określenie farmakologicznych właściwości leków roślinnych, w tym ich działania przeciwbólowego, przeciwzapalnego i wspomagającego regenerację tkanek. W tym aspekcie warto zwrócić uwagę na molekularne mechanizmy łagodzenia stanów zapalnych, w tym zdolności hamowania enzymu cyklooksygenazy (COX-2) oraz właściwości antyoksydacyjne substancji roślinnych.
19
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Comparison of phenylethanoids content in Rhodiola kirilowii and Rhodiola rosea roots applying a newly developed UPLC-MS/MS method

52%
Gryszczynska A., Lowicki Z., Opala B., Krajewska-Patan A., Buchwald W., Czerny B., Mielcarek S., Mrozikiewicz P. M.
Herba Polonica
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2012
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tom 58
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nr 4
A concentration of two phenylethanoids in the roots of two species: Rhodiola kirilowii and rosea were compared, aqueous and hydroalcoholic extracts from those plants were also analyzed. In order to determine the content of p-tyrosol and salidroside, the ultra performance liquid chromatography connected with a tandem mass spectrometry (UPLC-ESI MS/MS, Waters) was used. The obtained results shown that content of measured phenylethanoids depends on Rhodiola species. Roots of R. kirilowii contain more p-tyrosol, while R. rosea roots are reacher in salidroside. Our results indicate that the application of UPLC MS/MS method allows to determine the phenylethanoids content in tested samples with satisfactory precision.
20
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Determination of lotaustralin in Rhodiola species

52%
Gryszczynska A., Lowicki Z., Opala B., Krajewska-Patan A., Buchwald W., Czerny B., Mielcarek S., Mrozikiewicz P. M.
Herba Polonica
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2013
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tom 59
|
nr 2
In our research, the concentration of lotaustralin in the roots of two species Rhodiola kirilowii and Rhodiola rosea were compared. Aqueous and hydroalcoholic extracts from those plants were analyzed too. To determine the content of this compound the ultra performance liquid chromatography – tandem mass spectrometry (UPLC-MS/MS, Waters) was used. The obtained results showed that the content of measured lotaustralin depends on the species of Rhodiola. R. rosea roots are the richer source of lotaustralin then R. kirilowii. The same situation was observed in the extracts. A hydroalcoholic extract from R. rosea contains up to 135.276 mg of lotaustralin in 100 g of dry powdered material. In the case of R. kirilowii extracts, an aqueous extract contained more lotaustralin (74.791 mg/100 g of dry powdered material) then a hydroalcoholic extract.
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