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The determination of changes in the expression of genes for selected specific transcriptional factors in in vitro ductal breast cancer cells under the influence of paclitaxel

100%

Ziaja-Soltys M., Rzymowska J.

Cellular and Molecular Biology Letters

2011

tom 16

nr 4

This study aimed to determine the changes in the expression of genes for selected specific transcriptional factors that have both activating and repressing functions in in vitro ductal breast cancer cells, under the influence of paclitaxel, applying the microarray technique. The cells are treated with 60 ng/ml and 300 ng/ml doses of paclitaxel that correspond to those applied in breast cancer therapy. About 60 ng/ml doses of paclitaxel cause a statistically significant increase in expression of all the 16 analysed genes coding transcriptional factors, ranging from 1.84-fold (for PO4F2) to 4.65-fold (for LMO4) (p < 0.05) in comparison with the control cells, and enhanced the taxane mechanism of action. The 300 ng/ml doses of paclitaxel cause a cytotoxic effect in the cells. In this article, we argue that these changes in gene expression values may constitute prognostic and predictive factors in ductal breast cancer therapy.

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The evaluation of Entamoeba gingivalis occurrence in samples from patients with cancer and diabetes

51%

Kolodziej P., Luszczak J., Barczak S., Rzymowska J., Abramek J., Ziaja-Soltys M., Ziobro A., Grzesik D., Bogucka-Kocka A.

Annals of Parasitology

2016

tom 62

nr Suppl.

Massive demodicosis of the eyes in a patient with Sjogren syndrome: a case report

51%

Ziaja-Soltys M., Kolodziejczyk M., Rymgayllo-Jankowska B., Wrobel-Dudzinska D., Suchodola-Ratajewicz E., Szlonzak D., Zarnowski T., Bogucka-Kocka A.

Acta Parasitologica

2021

tom 66

nr 2

Ograniczanie wyników

1 Acta Parasitologica

1 Annals of Parasitology

1 Cellular and Molecular Biology Letters

3 Ziaja-Soltys M.

2 Bogucka-Kocka A.

2 Rzymowska J.

1 Abramek J.

1 Barczak S.

1 Grzesik D.

1 Kolodziej P.

1 Kolodziejczyk M.

1 Luszczak J.

1 Rymgayllo-Jankowska B.

1 Suchodola-Ratajewicz E.

1 Szlonzak D.

1 Wrobel-Dudzinska D.

1 Zarnowski T.

1 Ziobro A.

1 2021

1 2016

1 2011

Wyniki wyszukiwania

The determination of changes in the expression of genes for selected specific transcriptional factors in in vitro ductal breast cancer cells under the influence of paclitaxel

The evaluation of Entamoeba gingivalis occurrence in samples from patients with cancer and diabetes

Massive demodicosis of the eyes in a patient with Sjogren syndrome: a case report