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1

Pericytes and microvessel density assessment in women with ovarian malignant tumors

100%
Czekierdowska S., Rolinski J., Czekierdowski A., Bednarek W., Kotarski J.
Polish Journal of Environmental Studies
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2004
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tom 13
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nr Suppl.2, Part 1
Objective: The aim of this study was to assess ovarian cancer angiogenesis by comparing intratumoral microvessel density (MVD) with pericytes expression. Methods: Tumor specimens from 34 women operated because of malignant adnexal tumors were evaluated. Pericytes were assessed with anti-desmin antibody and microvessels were counted following CD-34 antigen detection. Histological type, grading, FIGO stage and menopausal status were compared with MVD and pericytes expression. Results: The means of MVD in serous and mucinous tumors were 25 (range: 8-83) and 22 (range: 8-50), respectively. The difference between medians of MVD and mean number of pericytes per high power field were not statistically significant. Also, there was no correlation between assessed markers and differentiation grade and FIGO stage and tumor type. Conclusion: MVD counting with CD-34 antigen, but not desmin expression for pericytes detection seems to be a useful parameter for neoangiogenesis assessment in ovarian cancers.
2

Prognostic significance of CD34, CD105 and EGF-R expression in women with serous ovarian cancer

86%
Bednarek W., Skomra D., Czekierdowski A., Smolen A., Czekierdowska S., Kotarski J.
Polish Journal of Environmental Studies
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2004
|
tom 13
|
nr Suppl.2, Part 1
The aim of the study was to determine the potential prognostic significance of intratumoral microvessel density assessment with panendothelial marker CD34, a new and specific marker for new blood microvessels CD 105, and a potent angiogenesis modulator, epidermal growth factor receptor (EGF-R) expression in women with serous ovarian cancer. Our results suggest that strong expression of EGF-R may be a prognostic of prognostic value in women operated because of serous cancer of ovaries.
3

A comparison of Bcl-2 expression, microvessel density and color Doppler sonography in the benign and malignant ovarian tumors

86%
Czekierdowska S., Rolinski J., Czekierdowski A., Bednarek W., Szumilo J., Kotarski J.
Polish Journal of Environmental Studies
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2004
|
tom 13
|
nr Suppl.2, Part 1
To compare Color Doppler sonography with immunohistochemical microvessel density and Bcl-2 assessement in women with benign and malignant adnexal tumors we examined 112 women with adnexal tumors with the use color Doppler sonography (B&K 2002 ADI and GE Voluson 730 scanners) performed before the surgical procedure. Histological type, grading, FIGO stage and menopausal status were compared with MVD and Bcl-2 expression assessed with immunohistochemistry on parafín embedded tumor specimens. Results: Sixty-seven tumors were benign and 45 tumors were malignant. The mean age of the studied women was 40,4 years; ±SD, 11,5 years. Color Doppler sonography revealed that in most malignant tumors there was a low resistance to flow (mean PI= 0,56, SD=0,36). Benign tumors also had higher pulsatility indices than malignant tumors (PI=1,21 and SD=0,48; p=0,02, Mann-Whitney U-test). Also, there was a statistically significant difference between MVD in benign and malignant tumors (Mann-Whitney U test, PO.OO 1). No significant difference in the percentage of Bcl-2 stained cells in both malignant and benign tumor samples was found. Conclusion: Microvessel density assessed with CD-34 and color Doppler blood flow assessement are useful in ovarian tumors vascularity studies. Bcl-2 expression is probably not a useful marker of angiogenic tumor character.
4
Content available remote

Microvessel density assessment in benign and malignant endometrial changes

86%
Czekierdowski A., Czekierdowska S., Czuba B., Cnota W., Sodowski K., Kotarski J., Zwirska-Korczala K.
Journal of Physiology and Pharmacology. Supplement
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2008
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tom 59
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nr 4
45-51
5
Content available remote

Microvessel density and CpG island methylation of THBS2 gene in malignant ovarian tumors

72%
Czekierdowski A., Czekierdowska S., Danilos J., Czuba B., Sodowski K., Sodowska H., Szymanski M., Kotarski J.
Journal of Physiology and Pharmacology. Supplement
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2008
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tom 59
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nr 4
53-65
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