Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 22

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Aktywność prokoagulanta nowotworowego (EC3.4.22.26) w surowicy krwi w przypadkach raka trzustki i raka tarczycy

100%
Szajda S., Snarska J., Chabielska E., Zalewska B.
Diagnostyka Laboratoryjna
|
2004
|
tom 40
|
nr 3
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

The influence of propranolol on the hypotensive action of ketanserin in normotensive rats

100%
Malinowska B., Pietraszek M., Chabielska E., Buczko W.
Acta Physiologica Polonica
|
1989
|
tom 40
|
nr 4
Malinowska, В., Pietraszek, M., Chabielska, E. and Buczko W.: The influence of propranolol on the hypotensive action of ketanserin in normotensive rats. Acta physiol, pol., 1989 40 (4): 356-362. In normotensive rats the effect of different doses of propranolol (1.0, 5.0 and 10.0 mg/kg i.p.) and ketanserin (10.0 mg/kg p.o.) on mean blood pressure and heart rate and on cardiovascular response to noradrenaline (0.1, 0.3, 0.5, 0,7 and 1.0 µg/kg i.v.) was examined. The drugs were given separately or together. Propranolol slightly reduced the hypotensive effect of ketanserin. On the other hand a decrease in heart rate caused by propranolol was not affected by ketanserin. Our results show that propranolol given with ketanserin did not change the effect of the latter on the cardiovascular system.
3
Content available remote

Losartan metabolite EXP3174 reduces the weight of formed thrombus in 2K1C hypertensive rats

100%
Gromotowicz-Poplawska A., Nazarko-Sadowska J., Chabielska E.
Journal of Physiology and Pharmacology
|
2019
|
tom 70
|
nr 3
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

The antithrombotic effect of captopril and losartan on experimental arterial thrombosis in rats

100%
Chabielska E., Pawlak R., Golatowski J., Buczko W.
Journal of Physiology and Pharmacology
|
1998
|
tom 49
|
nr 2
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

The role of endothelium in antithrombotic effect of the renin-angiotensin system blockade

100%
Buczko W., Matys T., Kucharewicz I., Chabielska E.
Journal of Physiology and Pharmacology
|
1999
|
tom 50
|
nr 4
6
Content available remote

The expression of the renin-angiotensin-aldosterone system in the skin and its effects on skin physiology and pathophysiology

88%
Aleksiejczuk M., Gromotowicz-Poplawska A., Marcinczyk N., Przylipiak A., Chabielska E.
Journal of Physiology and Pharmacology
|
2019
|
tom 70
|
nr 3
7

Assessment of proteasome activity and content in tissue homogenates of rats with renovascular hypertension

88%
Kruszewski K., Kalinowska J., Chabielska E., Nazarko J., Ostrowska H.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
8

Ebelactone B inhibits platelet aggregation in renovascular hypertensive rats

88%
Kalinowska J., Chabielska E., Kruszewski K., Nazarko J., Ostrowska H.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
9
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Antiplatelet action of losartan involves TXA2 receptor antagonism but not TXA2 synthase inhibition

88%
Chlopicki S., Koda M., Chabielska E., Buczko W., Gryglewski R. J.
Journal of Physiology and Pharmacology
|
2000
|
tom 51
|
nr 4,1
10
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Antithrombotic activity of losartan in two kidney, one clip hypertensive rats. A study on the mechanism of action

88%
Chabielska E., Pawlak R., Wollny T., Rolkowski R., Buczko W.
Journal of Physiology and Pharmacology
|
1999
|
tom 50
|
nr 1
11

Tissue distribution of a menthyl-conjugated oligodeoxyribonucleotide antisense to PAI-1 mRNA

88%
Szemraj J., Al-Nedawi K. N. I., Chabielska E., Buczko W., Pawlowska Z.
Acta Biochimica Polonica
|
2005
|
tom 52
|
nr 4
The inhibitory effect of numerous analogues of PO-16, an hexadecadeoxyribonucleotide antisense to sequences -22 to -17 of PAI-1 mRNA coding for a fragment of the signal peptide, on the expression of PAI-1 in endothelial cells, and physiological consequences of the subsequently reduced PAI-1 activity tested in vitro and in vivo, were described in our previous studies. Of particular interest was PO-16 5'-O-conjugated with menthyl phosphorothioate (MPO-16R). In this work, tissue localisation of MPO-16R labelled with [35S] phosphorothioate at the 3'-end, was determined. [35S]MPO-16R and control [35S]MPO-16R-SENSE oligonucleotides were administered intravenously into 22 rats and organ distribution of the labelled bioconjugates was assessed after 24 and 48 h. For this purpose, tissue sections were subjected to autoradiography, and quantitated by liquid scintillation after solubilisation. Overall clearance of radioactivity was already seen after 24 h, with the radioactivity recovered mainly in the kidney and liver. A smaller fraction of radioactivity was also retained in the spleen and heart. The kidney concentration of the labelled probe was higher than that of liver by 50%. The distribution of PAI-1 mRNA in untreated rat kidney, liver, spleen and heart established by two independent techniques: Ribonuclease Protection Assay and Real-Time PCR, shows the same pattern as that observed for [35S]MPO-16R antisense.
12
Content available remote

Angiotensin-(1-7): an active member of the renin-angiotensin system

88%
Kucharewicz I., Pawlak R., Matys T., Chabielska E., Buczko W.
Journal of Physiology and Pharmacology
|
2002
|
tom 53
|
nr 4,1
Angiotensin-(1-7) [Ang-(1-7)] is an active member of renin-angiotensin system (RAS). It counterbalances vasoconstriction, mitogenic, arrhythmogenic and prothrombotic actions of Ang II. Inducing natiuresis and diuresis opposes also the water and sodium retention produced by Ang II. Till now the specific receptor side for Ang-(1-7) has been not cloned, but the current data strongly suggest that an interaction (cross- talk) between angiotensin receptors may play a role in the effects of Ang-(1-7).
13
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Losartan inhibits the adhesion of rat platelets to fibrillar collagen - a potential role of nitric oxide and prostanoids

88%
Matys T., Chabielska E., Pawlak R., Kucharewicz I., Buczko W.
Journal of Physiology and Pharmacology
|
2000
|
tom 51
|
nr 4,1
14
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Hypotensive effect of angiotensin II after AT1-receptor blockade with losartan

88%
Matys T., Pawlak R., Kucharewicz I., Chabielska E., Buczko W.
Journal of Physiology and Pharmacology
|
2000
|
tom 51
|
nr 1
15
Content available remote

The proteome analysis of rat platelet with nano-liquid chromatography-matrix-assisted laser desorption/ionization time-of-flight mass spectrometry technique

76%
Gromotowicz-Poplawska A., Kasprzyk J., Marcinczyk N., Stepien E., Piekoszewski W., Chabielska E.
Journal of Physiology and Pharmacology
|
2018
|
tom 69
|
nr 6
16
Content available remote

Nitric oxide as a modulator in platelet- and endothelium-dependent antithrombotic effect of eplerenone in diabetic rats

76%
Gromotowicz-Poplawska A., Kloza M., Aleksiejczuk M., Marcinczyk N., Szemraj J., Kozlowska H., Chabielska E.
Journal of Physiology and Pharmacology
|
2019
|
tom 70
|
nr 2
17
Content available remote

Beneficial effect of combined spironolactone and quinapril treatment on thrombosis and hemostasis in 2K1C hypertensive rats

76%
Gromotowicz-Popławska A., Stankiewicz A., Mikita J., Aleksiejczuk M., Marcinczyk N., Szemraj J., Chabielska E.
Journal of Physiology and Pharmacology
|
2018
|
tom 69
|
nr 2
18

Construction of new thrombolytic and antithrombotic agents

76%
Kawecka I., Chabielska E., Janiszewska G., Buczko W., Adamczewska W., Szemraj J.
Cellular and Molecular Biology Letters
|
2001
|
tom 06
|
nr 3A
762
19

Wartość diagnostyczna badania aktywności nowotworowego prokoagulanta i katepsyny D w surowicy krwi pacjentów z rakiem wątroby

76%
Gabrylewska A., Snarska J., Szajda S. D., Zalewska B., Jankowski M., Skrzydlewski Z., Chabielska E.
Diagnostyka Laboratoryjna
|
2004
|
tom 40
|
nr 3
20
Content available remote

Angiotensin II via AT1 receptor accelerates arterial thrombosis in renovascular hypertensive rats

76%
Kaminska M., Mogielnicki A., Stankiewicz A., Kramkowski K., Domaniewski T., Buczko W., Chabielska E.
Journal of Physiology and Pharmacology
|
2005
|
tom 56
|
nr 4
Although there are some in vitro evidence that angiotensin II (Ang II) may promote thrombosis, there is still no data concerning effect of Ang II on arterial thrombus formation. In the present study we have investigated the influence of Ang II on electrically induced arterial thrombosis in a common carotid artery of renovascular hypertensive rats. Furthermore, we examined if Ang II effect is mediated via AT1 receptor. We measured some coagulation and fibrinolytic parameters at the same time. Since platelets play crucial role in the initiation of arterial thrombosis their contribution in the mode of Ang II action was also determined. Intravenous infusion of Ang II caused significant increase in arterial thrombus weight, which was reversed by losartan, selective AT1 receptor antagonist. The prothrombotic effect of Ang II was accompanied by increase in haemostatic and decrease in fibrinolytic potential of rat plasma. While number of data has clearly demonstrated that Ang II can augment human platelets aggregation, at least in rats, platelets were not involved in the mechanism of Ang II action. Our study shows that Ang II via AT1 receptor accelerates arterial thrombosis in renovascular hypertensive rat, therefore may be considered as a risk factor of myocardial infarction or stroke.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.