Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

The mitochondria mediate the induction of NOX1 gene expression by aldosterone in an ATF-1-dependent manner

100%

Fu Y., Shi G., Wu Y., Kawai Y., Qing T., Yue L., Xia Q., Miyamori I., Fan C.

Cellular and Molecular Biology Letters

2011

tom 16

nr 2

High aldosterone (Ald) levels can induce hypertrophy of vascular smooth muscle cells (VSMCs), which carries high risks of heart failure. A previous study showed that Ald induces hypertrophy of VSMCs by up-regulating NOX1, a catalytic subunit of NADPH oxidase that produces superoxides. However, the precise mechanism remains unknown. Diphenylene iodonium (DPI) is known as an inhibitor of complex I in the mitochondrial respiratory chain, and it was also found to almost completely suppress the induction of NOX1 mRNA and the phosphorylation of activating transcription factor (ATF-1) by PGF2α or PDGF in a rat VSMC cell line. In this study, we found that the Ald-induced phosphorylation of ATF-1 and NOX1 expression was significantly suppressed by DPI. Silencing of ATF-1 gene expression attenuated the induction of NOX1 mRNA expression, and over-expression of ATF-1 restored Ald-induced NOX1 expression. On the basis of this data, we show that the mitochondria mediate aldosterone-induced NOX1 gene expression in an ATF-1-dependent manner.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Fan C.

1 Fu Y.

1 Kawai Y.

1 Miyamori I.

1 Qing T.

1 Shi G.

1 Wu Y.

1 Xia Q.

1 Yue L.

1 2011

Wyniki wyszukiwania

The mitochondria mediate the induction of NOX1 gene expression by aldosterone in an ATF-1-dependent manner