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Presence of zearalenone in blood plasma in women with neoplastic lesions in the mammary gland

100%

Kuciel-Lisiecka G., Obremski K., Stelmachow J., Gajecka M., Zielonka L., Jakimiuk E., Gajecki M.

Bulletin of the Veterinary Institute in Puławy

2008

tom 52

nr 4

The aim of the study was to analyse data that can prove the correlation between the presence of zearalenone (ZEA) in the blood plasma and occurrence of mammary gland tumours. The study was carried out during one year on two hundred women. ZEA was detected in 74 patients (37%). Within this group, benign lesions were noted in 44 (59.5%) patients and malignant lesions in 30 (40.5%) patients. The presence of ZEA in the human organism increases the probability of hyperoestrogenism and in consequence the initiation of the growth of malignant and benign tumours.

Zmiany morfometryczne ukladu rozrodczego loszek podczas mikotoksykozy zearalenonowej

84%

Jakimiuk E., Kuciel-Lisiecka G., Zwierzchowski W., Gajecka M., Obremski K., Zielonka L., Skorska-Wyszynska E., Gajecki M.

Medycyna Weterynaryjna

2006

tom 62

nr 01

99-102

Oestrus status without standing reflex is enumerated among the typical clinical signs of zearalenone mycotoxicosis in sexually immature gilts. The aim of the study was to assess the influence of a low dose of zearalenone applied per os for 7 days on the morphometric results of the organs of the reproductive system in sexually immature gilts that were and that were not subjected to ovariectomy. Zearalenone and α-zearalenole were determined in blood plasma with the common use of separation methods with the columns of immunological affinity and high performance liquid chromatography with fluorescent detection. Tissues of the reproductive system were taken directly after the slaughter (on day 8 of the experiment) for morphometric examinations. The study was carried out on twelve 4 months old gilts, at 38-45 kg of body weight. The results obtained showed that per os application of zearalenone at a dose of 200 µg /kg b.w. for 7 days evoked signs of apparent sexual readiness without standing reflex in gilts after ovariectomy and in physiologically efficient gilts. The level of α-zearalenole had been significantly increased and zearalenone had been noted in blood serum before these signs appeared. Double and triple enlargement of the uterus was noted in both experimental groups. The mass and volume of the ovaries in physiologically efficient gilts diminished about 50%.

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Medycyna Weterynaryjna

2 Gajecka M.

2 Gajecki M.

2 Jakimiuk E.

2 Kuciel-Lisiecka G.

2 Obremski K.

2 Zielonka L.

1 Skorska-Wyszynska E.

1 Stelmachow J.

1 Zwierzchowski W.

1 2008

1 2006

Wyniki wyszukiwania

Presence of zearalenone in blood plasma in women with neoplastic lesions in the mammary gland

Zmiany morfometryczne ukladu rozrodczego loszek podczas mikotoksykozy zearalenonowej