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1

Carbonyl groups in plasma protein in children with malignant brain tumors

100%
Popadiuk S., Korzon M., Renke J., Wozniak M.
Polish Journal of Environmental Studies
|
1998
|
tom 07
|
nr 6
2

Carbonyl content in plasma proteins of children with connective tissue inflammatory diseases

100%
Korzon M., Renke J., Popadiuk S., Wozniak M.
Polish Journal of Environmental Studies
|
1998
|
tom 07
|
nr 6
3

Plasma protein carbonyls content reflect clinical severity of asthma

88%
Szlagatys A., Korzon M., Popadiuk S., Renke J., Wozniak M.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
4

Protein oxidation products and plasma antioxidants in juvenile idiopathic arthritis

76%
Renke J., Popadiuk S., Korzon M., Kalinska-Blach B., Szumera M., Wozniak M.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
5

Fecal lactoferrin, a marker of intestinal inflammation in children with inflammatory bowel disease

76%
Borkowska A., Liberek A., Luczak G., Jankowska A., Plata-Nazar K., Korzon M., Kaminska B.
Acta Biochimica Polonica
|
2015
|
tom 62
|
nr 3
6

The role of Cag A positive Helicobacter pylori strains in gastritis in children

76%
Sikorska-Wisniewska G., Korzon M., Roszkiewicz A., Kur J., Banach P., Liberek A.
Journal of Physiology and Pharmacology. Supplement
|
1997
|
tom 48
|
nr 1
7

Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children

64%
Kotlowska-Kmiec A., Bakowska A., Szarszewski A., Kaminska B., Luczak G., Radys W., Landowski P., Brodzicki J., Korzon M., Liberek A.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 3
433-438
The pathomechanism of Helicobacter pylori action upon gastric mucosa and its role in the pathogenesis of gastritis have not been fully elucidated. The aim of this study was to evaluate the most prevalent lymphocyte subpopulations of the gastric mucosa in gastritis in children, as well as to evaluate the expression of Fas and Fas ligand receptors (FasL), periapoptotic markers of gastric mucosa lymphocytes before and after H. pylori eradication. Forty nine patients aged 6 to 17 years, investigated due to chronic abdominal pain, were studied. The obtained tissue samples were analysed by immunohistochemistry. Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNγ) and Fas and FasL proteins in the gastric mucosa. B and T helper lymphocytes were found to play a major role in the inflammatory infiltration in the gastric mucosa in children during H. pylori infection. Their expression was found to decrease after eradication. The enhanced expression of Fas receptor on lymphocytes before treatment and a decrease of this expression after eradication of H. pylori were shown. It was demonstrated that there is a correlation between CD4 and Fas receptor expression that may induce apoptosis of the helper lymphocytes in infected children.
8

TGF-beta1, IL-10 and IL-4 in colostrum of allergic and nonallergic mothers

64%
Marek A., Zagierski M., Liberek A., Aleksandrowicz E., Korzon M., Krzykowski G., Kaminska B., Szlagatys-Sidorkiewicz A.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 3
411-414
Objective: To determine transforming growth factor (TGF) β1, interleukin (IL) 4, and IL-10 concentrations in human milk and to assess the relationship between allergic disorders in mothers and the content of the interleukins in their milk. Material and methods: Thirty allergic and 46 healthy mothers were included in the study. Colostrum was collected 2-3 days after delivery. Cytokine concentrations were determined with commercial enzyme-linked immunosorbent systems. Results: TGF-β1was found in milk from 23 women in the control group (53.49%) and 11 in the allergy group (37.93%). When TGF-β1 was present, the median concentration was higher in the allergy group than in the control (61.5 and 30.4 pg/mL, respectively; P < 0.004). IL-10 was present in the colostrum of all the women and the median IL-10 concentration did not differ between the allergy (50.5 pg/mL) and control (51.5 pg/mL) groups. The probability of occurrence of a positive IL-4 value in the allergy group was greater than in the control group (chi-squared [df = 1] = 2.60, P < 0.053). Median IL-4 level did not differ significantly between the two groups (0.5 and 0.5 pg/mL respectively). Conclusions: TGF-β1 was detected less often in the colostrum of allergic mothers than in that of mothers without allergy (but the difference was not statistically significant). IL-4 was found more often in the colostrum of allergic mothers than nonallergic ones. The allergy status did not correlate with IL-10 concentration.
9

Cystic fibrosis is a risk factor for celiac disease

64%
Walkowiak J., Blask-Osipa A., Lisowska A., Oralewska B., Pogorzelski A., Cichy W., Sapiejka E., Kowalska M., Korzon M., Szaflarska-Poplawska A.
Acta Biochimica Polonica
|
2010
|
tom 57
|
nr 1
115-118
 Background: The coexistence of cystic fibrosis (CF) and celiac disease (CD) has been reported. To our knowledge there is no study directly comparing the incidence of CD in CF patients to that in the general population at the same time. There is no published data on genetic predisposition to CD in CF patients either. Therefore, in the present study we aimed to assess the genetic predisposition to CD and its incidence in CF patients comparing it to data from the general population. Patients and methods: Two hundred eighty-two CF patients were enrolled in the study. In 230 CF patients the genetic predisposition to CD (the presence of HLA-DQ2/ DQ8) was assessed. In all CF patients, serological screening for CD was conducted. In patients with positive antiendomysial antibodies (EMA) gastroduenoscopy was offered. Intestinal histology was classified according to modified Marsh criteria. The results of serological CD screening in 3235 Polish schoolchildren and HLA-DQ typing in 200 healthy subjects (HS) were used for comparison. Results: Positive EMA was found in 2.84 % of the studied CF patients. The incidence of proven CD was 2.13 %. The incidence of CD as well as positive serological screening were significantly more frequent in the CF group than in the general population. The frequency of CD-related HLA-DQ alleles in CF and HS did not differ. Conclusions: Genetic predisposition to celiac disease in cystic fibrosis patients is similar to that of the general population. However, our results suggest that cystic fibrosis is a risk factor for celiac disease development.
10

A new method of oxidative stress intensity evaluation in children with juvenile chronic arthritis

64%
Zurawa D., Renke J., Popadiuk S., Korzon M., Skorko-Glonek J., Lipinska B., Bugajczyk B., Wozniak M.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
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