The following paper deals with the results of a long-lasting cannulation of the porcine pancreas performed using new methods. One method is based on a direct cannulation of the pancreatic duct after its incision. The other (designed by the authors) consists of a cannulation of the pancreas through the minor duodenal papilla. During the 14-day experimental period the efficiency of both methods was evaluated based upon certain indexes of the pancreatic juice secretions, including the level and daily dynamics of the secretions, as well as individual differentiations within two experimental groups. The method of cannulation through the minor duodenal papilla gave better results and a higher efficiency of the secretion, thus it was found to be more advantageous than the cannulation of the pancreatic duct after its incision.