The article characterizes the relevant state, level and dynamics of the entrepreneur sphere in the condition of the Prešov self-administration region in connection with the unified European economic market. The knowledge is based on the data gathered from the terrain research and analyses that are confronted with the present legal norm and the norms adapted from the European law. The author also indicates the possible trends of the development in this field that should create the suitable and appropriate conditions for further positive development of the entrepreneur environment from the regional, social and European point of view.