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Characteristics of the Pseudomonas aeruginosa PA01 intercellular signaling pathway (Quorum Sensing) functioning in presence of porphyrins bismuth complexes

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Galkin M., Iwanitsia V., Ishkov Y., Galkin B., Flipova T.

Polish Journal of Microbiology

2015

tom 64

nr 2

The influence of synthetic and natural porphyrins bismuth complexes on P. aeruginosa quorum sensing system was carried out by detection of the pyocyanin, rhamnolipids and autoinducers biosynthesis level. The highest ability to reduce pyocyanin biosynthesis showed Bi(III)-TPP. Rhamnolipids production level also decreased in the presence of studied compounds. This effect was the most expressed in presence of 40 and 80 μM of the synthetic meso-substituted porphyrins. Autoinducers biosynthesis, especially 3-oxo-C₁₂-HSL was suppressed in presence of the bismuth complexes. That suggest that the mechanisms of action of this substances is an inhibition of signaling molecules or/and receptor for them.

Ograniczanie wyników

1 Polish Journal of Microbiology

1 Flipova T.

1 Galkin B.

1 Galkin M.

1 Ishkov Y.

1 Iwanitsia V.

1 2015

Wyniki wyszukiwania

Characteristics of the Pseudomonas aeruginosa PA01 intercellular signaling pathway (Quorum Sensing) functioning in presence of porphyrins bismuth complexes