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Differential antitumor effect of essential oils and their major components of Thymus broussonettii: relationship to cell cycle and apoptosis induction

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Jaafari A., Ait Mouse H., Ait M'Bark L., Tilaoui M., Elhansali M., Lepoivre M., Aboufatima R., Melhaoui A., Chait A., Zyad A.

Herba Polonica

2009

tom 55

nr 2

36-50

Thymus broussonettii, a Moroccan endemic plant, exists in two chemotypes. The aim of our study is to compare the cytotoxic activity of their essential oils and major products as well as their effect on cell cycle and apoptosis induction. The chemical composition analysis of essential oils by GC-SM revealed that the lasts are rich and diverse and the major products of the chemotypes TbA and TbE are carvacrol and thymol, respectively. The in vitro cytotoxic effect study against five tumor cell lines shows that TbA essential oil, rich in carvacrol, has an important cytotoxic effect, higher than that of TbE, rich in thymol. This result is confirmed by comparing cytotoxic effect of carvacrol and thymol. Furthermore, TbA EO /carvacrol and TbE EO /thymol induce cell cycle arrest at S and G0/G1 phases, respectively. On the other hand, carvacrol, most cytotoxic in vitro, was studied for its effect on solid tumor in vivo and apoptosis-induction. Our results show that carvacrol, administred by gavage, has an important effect on solid tumor and induce apoptosis in P815 tumor cell line.

Ograniczanie wyników

1 Herba Polonica

1 Aboufatima R.

1 Ait M'Bark L.

1 Ait Mouse H.

1 Chait A.

1 Elhansali M.

1 Jaafari A.

1 Lepoivre M.

1 Melhaoui A.

1 Tilaoui M.

1 Zyad A.

1 2009

Wyniki wyszukiwania

Differential antitumor effect of essential oils and their major components of Thymus broussonettii: relationship to cell cycle and apoptosis induction