Paraoxonase (PON) protects low-density lipoproteins from oxidation. Gln192Arg genotype of PON was identifi ed as a risk factor for stroke. The aim of our study was to evaluate the activity of the esterase and concentration of conjugated dienes (CD) in the early phase of stroke and its clinical signifi cance. Material and methods: The PON activity and conjugated dienes (CD) concentrations were analyzed within fi rst 24 hours after stroke onset by means of spectrophotometric methods. Results: We included into the study 424 persons [403 ischemic stroke (IS) patients, aged 67 ± 12 and 21 patients with IS secondary hemorrhagic transformation (SHT), aged 69 ± 11 and 12 age-matched healthy controls]. The PON activity was lower in SHT patients (13.2; interquartile range 2.3ñ67.1 U/L) comparing to IS patients (63.7; 40.2ñ145.9 U/L) and controls (42.34; 38.98ñ57.44 U/L) (P<0.05). There was no signifi cant difference in CD concentration between IS and SHT patients (P>0.05). Multiple regression analysis revealed correlations between CD concentration and Barthel index in IS and SHT, and between PON activity and Barthel index in HT patients. Conclusion The serum PON activity in early phase of stroke was signifi cantly lower in SHT than in IS patients. PON activity showed correlation with clinical outcome in SHT patients whereas CD concentrations correlated with the outcome in both IS and SHT groups.
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