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1

Wplyw cytokin prozapalnych [TNF-alfa, IL-1 i IL-6] na czynnosc serca

100%
Paslawska U., Kiczak L., Ugorski M., Chelmonska-Soyta A.
Medycyna Weterynaryjna
|
2008
|
tom 64
|
nr 08
969-972
Cytokines are a group of peptides or small proteins that are involved in intercellular communication. Most of them are involved in local processes but some have endocrine activity. Cytokines are produced mainly by lymphocytes, monocytes, granulocytes, but also by fibroblasts, endothelial and epithelial cells. Disturbances of the integrity of tissues are the main inducers of cytokine synthesis connected with local immune response. On the other hand there is the group of constitutively produced cytokines that regulates the processes of hematopoesis, tissue remodeling, and lymphocytes migration. At present over one hundred biologically active substances described as cytokines have been identified. High levels of TNF-α, IL-1β i IL-6 are demonstrated both in severe cardiac insufficiency with cachexia and in the left sided cardiac failure. It has been established in several studies that proinflamatory cytokines contribute to dilated cardiomiopathy involvement, decreased blood perfusion in skeletal muscles, and exert endothelial injury of vessels, develop cachexia and inappetance and stimulate cardiac myocytes apoptosis. It was confirmed that cardiac myocytes are able to synthetize TNF-α in response to different types of overload, e.g. volume overload, pressure or ischemic (post infarct). TNF-α and IL-2 impart a negative inotropic effect on the heart proportional to their concentration. TNF-α, IL-1 and IL-6 regulate cardiac functioning indirectly due to the activity of the following: nitric oxide, reactive oxygen species, sphingolipid mediators, arachidonic acid and the modulation of β-adrenergic response.
2

Rola tlenku azotu w regulacji czynności układu krążenia

100%
Paslawska U., Kurzok H., Kiczak L., Bania J.
Medycyna Weterynaryjna
|
2012
|
tom 68
|
nr 06
Nitric oxide (NO, earlier known as EDFR - Endothelium-Derived Relaxing Factor) is a multifunctional particle involved in physiological as well as pathological reactions. The specificity of these reactions depends on the NO concentration, location and interactions with other particles. Nitric oxide affects the dilatation of blood vessels and immunological reaction. It influences cardiovascular myocyte tonus (contraction) and counteracts vasoconstrictive factors such as endothelin-1 and angiotensin-II, thereby ensuring proper tissue perfusion depending on current requirements. NO protects vessel walls by preventing lipid peroxidation and decreasing the activity of reactive oxygen radicals. Nitric oxide shows anticoagulant properties by inhibiting the adhesion, activation and aggregation of trombocytes.
3

Czy leczenie niewydolności serca psów może być proste?

88%
Paslawska U., Dziegiel P., Sambor I., Kiczak L., Paslawski R.
Magazyn Weterynaryjny
|
2010
|
tom 19
|
nr 12
4

Przewlekła niewydolność serca. Czy zwłóknienie ma znaczenie?

88%
Paslawska U., Dziegiel P., Sambor I., Kiczak L., Paslawski R.
Weterynaria w Praktyce
|
2010
|
tom 07
|
nr 07-08
5

Phage display of proteins

88%
Koscielska K., Kiczak L., Kasztura M., Wesolowska O., Otlewski J.
Acta Biochimica Polonica
|
1998
|
tom 45
|
nr 3
In recent years the phage display approach has become an increasingly popular method in protein research. This method enables the presentation of large peptide and protein libraries on the surface of phage particles from which molecules of desired functional property(ies) can be rapidly selected. The great advantage of this method is a direct linkage between an observed phenotype and encapsulated genotype, which allows fast determination of selected sequences. The phage display approach is a powerful tool in generating highly potent biomolecules, including: search for specific antibodies, determining enzyme specificity, exploring protein-protein and protein-DNA interactions, minimizing proteins, introducing new functions into different protein scaffolds, and searching sequence space of protein folding. In this article many examples are given to illustrate that this technique can be used in different fields of protein science. The phage display has a potential of the natural evolution and its possibilities are far beyond rational prediction. Assuming that we can design the selection agents and conditions we should be able to engineer any desired protein function or feature.
6

Niedotlenienie, czyli rola czynnika indukowanego hipoksją (HIF)

76%
Paslawska U., Kiczak L., Michlik K., Noszczyk-Nowak A., Paslawski R., Jonkisz P.
Magazyn Weterynaryjny
|
2013
|
tom 22
|
nr 01
7

Analiza genu fimH kodujacego adhezyne fimbrii typu 1 Salmonella enterica serowar Enteritidis

76%
Kisiela D., Kiczak L., Kuzminska M., Kuczkowski M., Franiczek R., Ugorski M.
Medycyna Weterynaryjna
|
2005
|
tom 61
|
nr 11
1259-1262
8
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Content available

Effect of short-term rapid ventricular pacing followed by pacing interruption on arterial blood pressure in healthy pigs and pigs with tachycardiomyopathy

52%
Skrzypczak P., Zysko D., Paslawska U., Noszczyk-Nowak A., Janiszewski A., Gajek J., Nicpon J., Kiczak L., Bania J., Zacharski M., Tomaszek A., Jankowska E. A., Ponikowski P., Witkiewicz W.
Polish Journal of Veterinary Sciences
|
2014
|
tom 17
|
nr 1
Ventricular tachycardia may lead to haemodynamic deterioration and, in the case of long term persistence, is associated with the development of tachycardiomyopathy. The effect of ventricular tachycardia on haemodynamics in individuals with tachycardiomyopathy, but being in sinus rhythm has not been studied. Rapid ventricular pacing is a model of ventricular tachycardia. The aim of this study was to determine the effect of rapid ventricular pacing on blood pressure in healthy animals and those with tachycardiomyopathy. A total of 66 animals were studied: 32 in the control group and 34 in the study group. The results of two groups of examinations were compared: the first performed in healthy animals (133 examinations) and the second performed in animals paced for at least one month (77 examinations). Blood pressure measurements were taken during chronic pacing - 20 min after onset of general anaesthesia, in baseline conditions (20 min after pacing cessation or 20 min after onset of general anaesthesia in healthy animals) and immediately after short-term rapid pacing. In baseline conditions significantly higher systolic and diastolic blood pressure was found in healthy animals than in those with tachycardiomyopathy. During an event of rapid ventricular pacing, a significant decrease in systolic and diastolic blood pressure was found in both groups of animals. In the group of chronically paced animals the blood pressure was lower just after restarting ventricular pacing than during chronic pacing. Cardiovascular adaptation to ventricular tachycardia develops with the length of its duration. Relapse of ventricular tachycardia leads to a blood pressure decrease more pronounced than during chronic ventricular pacing.
9
Content available remote

Matrix metalloproteinase 9/neutrophil gelatinase associated lipocalin/tissue inhibitor of metalloproteinases 1 complexes are localized within cardiomyocytes and serve as a reservoir of active metalloproteinases in porcine female myocardium

52%
Kiczak L., Tomaszek A., Bania J., Paslawska U., Zacharski M., Janiszewski A., Rybinska I., Dziegiel P., von Haehling S., Ardehali H., Jankowska E. A., Ponikowski P.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 3
10

Technika implantacji sztucznego stymulatora serca u świni domowej w modelu przewlekłej niewydolności serca indukowanej tachykardią

52%
Janiszewski A., Paslawska U., Gajek J., Skrzypczak P., Noszczyk-Nowak A., Zosko D., Kiczak L., Bania J., Tomaszek A., Zacharski M., Nicpon J., Banasiak W., Jankowska E., Ponikowski P.
Annals of Warsaw University of Life Sciences - SGGW. Animal Science
|
2011
|
tom 48
11

P-R interval in porcine model of chronic tachycardia-induced cardiomyopathy

52%
Skrzypczak P., Zysko D., Paslawska U., Noszczyk-Nowak A., Janiszewski A., Kiczak L., Bania J., Zacharski M., Tomaszek A., Rybinska I., Nicpon J., Paslawski R., Gajek J., Jankowska E. A., Ponikowski P.
Bulletin of the Veterinary Institute in Puławy
|
2013
|
tom 57
|
nr 3
The aim of the study was to assess the atrioventricular conduction in the model of porcine pacing induced tachycardiomyopathy. Fifty-one swine were examined: 27 were paced and 24 served as a control group. Every 4 weeks, the animals were anaesthetised for 1 h and an ECG Holter was performed. Thirty minutes after the onset of anaesthesia, P-R and R-R intervals were measured. Each result was assigned to the subgroup according to the animal's weight and the presence or absence of previous pacing. P-R interval was longer in animals after at least 4 weeks of rapid ventricular stimulation than in adjusted group of the animals according to the body mass. Multivariate analysis has showed that longer P-R interval was related to male gender, higher body mass, slower heart rate, and history of previous pacing. Chronic ventricular pacing led to the slowing of atrioventricular conduction. The presence of differences in the duration of R-R intervals between groups was only found in swine weighing 120-139 kg. The R-R interval was shorter in paced animals, whereas PR interval was longer in that group, indicating that PR prolongation is related to electrical or structural remodelling of the cardiac conductive tissue but not increased sympathetic nervous system activity, which is expected to produce corresponding changes in PR and R-R intervals.
12
Content available remote

Increased gene expression of catecholamine-synthesizing enzymes in adrenal glands contributes to high circulating catecholamines in pigs with tachycardia-induced cardiomyopathy

52%
Tomaszek A., Kiczak L., Bania J., Paslawska U., Zacharski M., Janiszewski A., Noszczyk-Nowak A., Dziegiel P., Kuropka P., Ponikowski P., Jankowska E. A.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 2
13

Duze zwierzeta modelem niewydolnosci serca

52%
Noszczyk-Nowak A., Jankowska E., Paslawska U., Janiszewski A., Kiczak L., Bania J., Tomaszek A., Zacharski M., Nicpon J., Ugorski M., Ponikowski P., Banasiak W.
Medycyna Weterynaryjna
|
2010
|
tom 66
|
nr 06
378-382
Congestive heart failure is a clinical syndrome whose hallmarks are fatigue and dyspnea. Common pathophysiologic features of heart failure include changes in the structure of the left ventricle of the heart, function, and neurohormonal activation. A recapitulation of the heart failure phenotype in a large animal model can make it possible to translate basic science discoveries into clinical therapies. Models of myocardial infarction/ischemia, ischemic cardiomyopatyhy, ventricular pressure and volume overload and pacing- -induced dilated cardiomyopathy have been created for dogs, pigs and sheep to investigate heart failure and potential therapies. This article presents types of large animal models of heart failure, methods of their development and their clinical usefulness.
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