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1

Insights on neurochemical mechanisms of hyperactivity and potentially new therapeutic strategies

100%
Kostrzewa R. M., Brus R.
Acta Neurobiologiae Experimentalis
|
1999
|
tom 59
|
nr 3
2

Dopamine receptor supersensitivity

100%
Kostrzewa R. M., Brus R.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
3

Nitric oxide (NO) and central dopamine (DA) receptors reactivity in rats

81%
Brus R., Szkilnik R., Nowak P., Kostrzewa R. M.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
4

Sensitization to dopamine (DA) and 5-hydroxy-tryptamine (5-HT) agonists is not correlated with alterations in DA and 5-HT contents of neostriatum after neonatal intrastriatal 6-hydroxydopamine injections in rats

81%
Kostrzewa R. M., Brus R., Perry K. W., Fuller R. W.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
5

Effect of L-arginine and nitro-L-arginine methyl ester (L-NAME) on amphetamine and apomorphine induced stereotyped behavior and Dopac release in the striatum of rats

81%
Kasperska A., Brus R., Sokola A., Kostrzewa R. M.
Acta Neurobiologiae Experimentalis
|
1999
|
tom 59
|
nr 3
6

Developmental lead exposure impairs anxiolytic-like effect of diazapam and 8-OH-DPAT in male Wistar rats

81%
Nowak P., Kostrzewa R. M., Adamus-Sitkiewicz B., Brus R.
Polish Journal of Environmental Studies
|
2008
|
tom 17
|
nr 5
751-756
The effects of developmental lead (Pb²⁺) exposure on the anxiolytic-like effect of diazepam (5.0 mg/kg IP) and 8-OH-DPAT (0.3 mg/kg IP) were studied. Wistar dams were exposed to 250 ppm lead acetate in drinking water during pregnancy. Control rats were derived from dams that consumed tap water, and had no exposure to Pb²⁺ afterwards. Male offspring were tested at the age of 12 weeks. We studied the anxiolytic-like effect of diazepam and 8-OH-DPAT in an elevated plus maze device and the Vogel conflict test. Diazepam in doses of 5.0 mg/kg IP significantly increased the percentage of time spent on open arms in control rats being without effect in Pb²⁺-exposed animals. 8-OH-DPAT 0.3 mg/kg IP increased the percentage of time spent on open arms in both experimental groups (control and Pb²⁺), but the anxiolytic-like effect was much more pronounced in Pb²⁺-intoxicated animals. The benzodiazepine anxiolytic diazepam produced a significant effect in the Vogel conflict test in control rats. A 5.0 mg/kg dose of those drugs caused a significant increase in the number of electric shocks rats received. In the ontogenetically Pb²⁺-exposed rats diazepam also augmented the number of shocks accepted, but this effect was much less pronounced than in control animals. Conversely, 8-OH-DPAT at doses of 0.3 mg/kg IP was without effect in both tested groups as far as the anticonflict effect is concerned. The results of the present report demonstrated that exposure to Pb²⁺ during pregnancy induced hypersensitivity to 5-HT1A agonist mediated anxiolytic-like effect but attenuated that of benzodiazepine (diazepam).
7

Effect of the central dopamine and serotonin receptor agonist on biogenic amines release in rats brain with experimental model of attention deficit hyperactivity disorder (ADHD) in vivo brain microdialysis study

81%
Nowak P., Brus R., Szkilnik R., Kostrzewa R. M.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
8

Serotonin (5-HT) systems mediate dopamine (DA) receptor supersensiticity

81%
Kostrzewa . R. M., Gong L., Brus R.
Acta Neurobiologiae Experimentalis
|
1992
|
tom 52
|
nr 3
9

Central noradrenergic system lesion by DSP-4 prevent qninpirole ontogenically sensitization to quinpirole-induced yawning in rats

81%
Nowak P., Labus L., Kostrzewa R. M., Brus R.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 3
10

Nitro-l-arginine attenuates SKF 38393 - induced oral activity in neonatal 6-hydroxydopamine-lesioned rats

81%
Brus R., Szkilnik R., Nowak P., Kostrzewa R. M.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 4
11

Serotonin [5-HT] systems mediate dopamine [DA] receptor supersensitivity

81%
Kostrzewa R. M., Gong L., Brus R.
Acta Neurobiologiae Experimentalis
|
1993
|
tom 53
|
nr 1
12

Nitric oxide [NO] and central dopamine [DA] D3 receptor reactivity to quinpirole in rats

81%
Brus R., Szkilnik R., Kostrzewa R. M.
Acta Neurobiologiae Experimentalis
|
1996
|
tom 56
|
nr 1
13

Dopamine and 5-HT receptor sensitivity does not correlate with neostriatal dopamine or 5-HT content

81%
Kostrzewa R. M., Brus R., Perry K. W., Fuller R. W.
Acta Neurobiologiae Experimentalis
|
1996
|
tom 56
|
nr 1
14

Effect of the aminoacid L-Arginine and its analog Nitro-L-Aginine methyl ester HCl (L-Name) on central dopamine (DA) receptor reactivity

71%
Brus R., Szkilnik R., Kasperska A., Oswiecimska J., Kostrzewa R. M.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
15

Behavioral and biochemical effects of new central dopamine D3 ((U-99194A) and D4 (U- 10 1958) receptor antagonists in rats

71%
Brus R., Nowak P., Sokola A., Kostrzewa R. M., Shani J.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
16

Comparison DOPAC release in the striatum and some behavioral effects of quinpirole and 7-OH-DPAT, the dopamine D2/D3 receptors agonists in rats

71%
Brus R., Oswiecimska J., Szkilnik R., Sokola A., Kostrzewa R. M.
Acta Neurobiologiae Experimentalis
|
1999
|
tom 59
|
nr 3
17

In vivo voltammetric determination of the enhanced spiperone - induced release of dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) in neostriatum of rats with supersensitized DA D2-receptors

71%
Brus R., Kostrzewa R. M., Jedrusiak J., Szkilnik R., Wojtowicz L.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
18
Content available remote

7-nitroindazole enhances amphetamine-evoked dopamine release in rat striatum. An in vivo microdialysis and voltammetric study

71%
Nowak P., Brus R., Oswiecimska J., Sokola A., Kostrzewa R. M.
Journal of Physiology and Pharmacology
|
2002
|
tom 53
|
nr 2
The intracellular second messenger nitric oxide (NO) is implicated in a variety of physiological functions, including release and uptake of dopamine (DA). In the described study, in vivo microdialysis and differential pulse voltammetric techniques were used to determine the involvement of NO in release of DA and its metabolites (dihydroxyphenylalanine, DOPAC; homovanillic acid, HVA) in neostriatum of freely moving rats. While the NO donor molsidomine (30.0 mg/kg; MOLS) and neuronal NO synthase- (nNOS-) inhbitor 7-nitroindazole (10.0 mg/kg; 7-NI) had no effect on the basal in vivo microdialysate level of DA, 7-NI specifically enhanced D,L-amphetamine- (1.0 mg/kg i.p.; AMPH) evoked release of DA. Basal or AMPH effects on DOPAC and HVA levels were not influenced by MOLS or 7-NI. Findings indicate that nitrergic systems have an important role in mediating effects of AMPH on dopaminergic systems.
19
Content available remote

Effect of ketanserin and amphetamine on nigrostriatal neurotransmission and reactive oxygen species in Parkinsonian rats. In vivo microdialysis study

61%
Nowak P., Szczerbak G., Biedka I., Drosik M., Kostrzewa R. M., Brus R.
Journal of Physiology and Pharmacology
|
2006
|
tom 57
|
nr 4
5-HT2A/2C receptors are one of the most important in controlling basal ganglia outputs. In rodent models of Parkinson's disease (PD) blockade of these receptors increases locomotion and enhances the actions of dopamine (DA) replacement therapy. Moreover, previously we established that 5-HT2A/2C antagonist attenuate DA D1 agonist mediated vacuous chewing movements (VCMs) which are considered as an animal representation of human dyskinesia. These findings implicate 5-HT neuronal phenotypes in basal ganglia pathology, and promote 5-HT2 antagonists as a rational treatment approach for dyskinesia that is prominent in most instances of PD replacement therapy. In the current study we determined whether ketanserin (KET) and/or amphetamine (AMPH) affected dopaminergic neurotranssmision in intact and fully DA-denervated rats. Moreover, we looked into extraneuronal content of HO. of the neostriatum after AMPH and/or KET injection, assessed by HPLC analysis of dihydroxybenzoic acids (2,3- and 2, 5-DHBA) - spin trap products of salicylate. Findings from the present study demonstrated that there are no substantial differences in extraneuronal HO. generation in the neostriatum between control and parkinsonian rats. KET did not affect DA release in the fully DA-denervated rat's neostriatum and also did not enhance HO. production. As 5-HT2A/2C receptor-mediated transmission might prove usefulness not only in addressing motor complications of PD patients (dyskinesia) but also in addressing non-motor problems such depression and/or L-DOPA evoked psychosis, the findings from the current study showed that the use of 5-HT2A/2C receptor antagonists in Parkinson's disease does not impend the neostriatal neuropil to be damaged by these drugs. We concluded that 5-HT2A/2C receptor antagonists may provide an attractive non-dopaminergic target for improving therapies for some basal ganglia disorders.
20
Content available remote

Neurotoxic action of 6-hydroxydopamine on the nigrostriatal dopaminergic pathway in rats sensitized with D-amphetamine

61%
Nowak P., Kostrzewa R. M., Kwiecinski A., Bortel A., Labus L., Brus R.
Journal of Physiology and Pharmacology
|
2005
|
tom 56
|
nr 2
To determine whether behavioral sensitization produced by prolonged D-amphetamine administration affects susceptibility of nigrostriatal dopaminergic neurons to the neurotoxic actions of 6-hydroxydopamine (6-OHDA), rats were treated daily from the 23 rd day after birth for 11 consecutive days with D-amphetamine (1.0 mg/kg s.c.) or saline. On the last day of treatment, one group primed with D-amphetamine and one control group of rats were tested to confirm behavioral sensitization development. The remaining animals were additionally treated on the 34 th day (one day after the last D-amphetamine injection) with 6-OHDA HBr (300 µg in 10 µl i.c.v., salt form, half in each lateral ventricle) or its vehicle. Four weeks later the levels of dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-metoxytyramine (3-MT), as well as 5-hydroxytrypatmine (5-HT) and its metabolite 5-hydroxyindoleacteic acid (5-HIAA) were assayed in the striatum, by HPLC/ED. In rats with behavioral sensitization, 6-OHDA reduced endogenous dopamine and its metabolites content to a comparable degree in comparison to controls. This finding indicates that presumed up-regulation of the dopamine transporter in the behaviorially sensitized rats did not increase the neurotoxicity of a high dose of 6-OHDA.
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