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2,3-butanedione monoxime [BDM] protects neonatal rat cardiomyocytes in culture from oxidative stress induced by different agents

100%

Przygodzki T., Sokal A., Zlotkin E.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

2

Interaction of nitroxides and mitoxantrone with the plasma of cardiomyocytes

88%

Koceva-Chyla A., Sokal A., Kania K., Gwozdzinski K., Jozwiak Z.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

3

The nitroxides pirolin and pirolid protect the plasma membranes of rat cardiomyocytes against damage induced by anthracyclines

88%

Koceva-Chyla A., Sokal A., Kania K., Gwozdzinski K., Jozwiak Z.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 1

This study was performed to evaluate the protective effects of pyrroline and pyrrolidine nitroxides Pirolin, PL, and Pirolid, PD, on the plasma membranes of rat cardiomyocytes treated in vitro with anthracycline drugs aclarubicin (ACL) and doxorubicin (DOX). The influence of two concentrations of drugs (10 and 20 μM) and nitroxides (0.1 and 1 mM) as well as their combinations (a drug and a nitroxide) on membrane fluidity was investigated. The plasma membranes of cardiomyocytes were labelled with a hydrophobic fluorescence probe 12-AS and membrane fluidity was estimated on the basis of the fluorescence anisotropy of the probe. We found that aclarubicin and doxorubicin induced a significant dose-dependent decrease in membrane fluidity, whereas the nitroxides (PL and PD) caused its increase. Preincubation of cardiomyocytes with Pirolin entirely protected plasma membranes of these cells against damage caused by DOX. In the same conditions no protective effect of Pirolid was observed. What is more, Pirolid in combination with DOX caused fluidisation of the plasma membranes of cardiomyocytes. Both nitroxides at low concentration (0.1 mM) protected plasma membranes against rigidification induced by aclarubicin, while high concentration (1 mM) was ineffective and caused fluidisation of the plasma membranes of cardiomyocytes.

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Transport of organic anions by multidrug resistance-associated protein in the erythrocyte

88%

Rychlik B., Pulaski L., Sokal A., Soszynski M., Bartosz G.

Acta Biochimica Polonica

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2000

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tom 47

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nr 3

The active transport of oxidized glutathione and glutathione S-conjugates has been demonstrated for the first time in erythrocytes and this cell remained the main subject of research on the glutathione S-conjugate pump for years. Further studies identified the glutathione S-conjugate pump as multidrug resistance-associated protein (MRP). Even though cells overexpressing MRP and isolated MRP provide useful information on MRP structure and function, the erythrocyte remains an interesting model cell for studies of MRP1 in its natural environment, including the substrate specificity and ATPase activity of the protein.

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The nitroxides pirolin and pirolid protect the plasma membrane of rat cardiomiocytes against damage induced by anthracyclines

88%

Koceva-Chyla A., Sokal A., Kania K., Gwozdzinski K., Jozwiak Z.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

6

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Nutrition habits and frequency of consumption of selected food products by the residents of urban and rural area from the Subcarpathian voivodeship

76%

Szalajko M., Stachowicz W., Dobosz M., Szalankiewicz M., Sokal A., Luszczki E.

Roczniki Państwowego Zakładu Higieny

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2021

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tom 72

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nr 2

Ograniczanie wyników

3 Cellular and Molecular Biology Letters

2 Acta Biochimica Polonica

1 Roczniki Państwowego Zakładu Higieny

6 Sokal A.

3 Gwozdzinski K.

3 Jozwiak Z.

3 Kania K.

3 Koceva-Chyla A.

1 Bartosz G.

1 Dobosz M.

1 Luszczki E.

1 Przygodzki T.

1 Pulaski L.

1 Rychlik B.

1 Soszynski M.

1 Stachowicz W.

1 Szalajko M.

1 Szalankiewicz M.

1 Zlotkin E.

1 2021

2 2003

2 2002

1 2000

2,3-butanedione monoxime [BDM] protects neonatal rat cardiomyocytes in culture from oxidative stress induced by different agents

Interaction of nitroxides and mitoxantrone with the plasma of cardiomyocytes

The nitroxides pirolin and pirolid protect the plasma membranes of rat cardiomyocytes against damage induced by anthracyclines

Transport of organic anions by multidrug resistance-associated protein in the erythrocyte

The nitroxides pirolin and pirolid protect the plasma membrane of rat cardiomiocytes against damage induced by anthracyclines

Nutrition habits and frequency of consumption of selected food products by the residents of urban and rural area from the Subcarpathian voivodeship