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An expert system to predict climate change induced salinization processes in salt-affected soils

100%

Feher J., Rajkai K.

International Agrophysics

1996

tom 10

nr 3

Occlusion of retinal capillaries caused by glial cell proliferation in chronic ocular inflammation

51%

Bianchi E., Ripandelli G., Feher J., Plateroti A. M., Plateroti R., Kovacs I., Plateroti P., Taurone S., Artico M.

Folia Morphologica

2015

tom 74

nr 1

The inner blood-retinal barrier is a gliovascular unit in which glial cells surround capillary endothelial cells and regulate retinal capillaries by paracrine interactions. During chronic ocular inflammation, microvascular complications can give rise to vascular proliferative lesions, which compromise visual acuity. This pathologic remodelling caused by proliferating Müller cells determines occlusion of retinal capillaries. The aim of the present study was to identify qualitative and quantitative alterations in the retinal capillaries in patients with post-traumatic chronic ocular inflammation or post-thrombotic vascular glaucoma. Moreover, we investigated the potential role of vascular endothelial growth factor (VEGF) and pro-inflammatory cytokines in retinal inflammation. Our electron microscopy findings demonstrated that during chronic ocular inflammation, thickening of the basement membrane, loss of pericytes and endothelial cells and proliferation of Müller cells occur with irreversible occlusion of retinal capillaries. Angiogenesis takes place as part of a regenerative reaction that results in fibrosis. We believe that VEGF and pro-inflammatory cytokines may be potential therapeutic targets in the treatment of this disease although further studies are required to confirm these findings. (Folia Morphol 2015; 74, 1: 33–41)

Ograniczanie wyników

1 Folia Morphologica

1 International Agrophysics

2 Feher J.

1 Artico M.

1 Bianchi E.

1 Kovacs I.

1 Plateroti A. M.

1 Plateroti P.

1 Plateroti R.

1 Rajkai K.

1 Ripandelli G.

1 Taurone S.

1 2015

1 1996

Wyniki wyszukiwania

An expert system to predict climate change induced salinization processes in salt-affected soils

Occlusion of retinal capillaries caused by glial cell proliferation in chronic ocular inflammation