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Stem cells from adipose tissue

100%

Witkowska-Zimny M., Walenko K.

Cellular and Molecular Biology Letters

2011

tom 16

nr 2

This is a review of the growing scientific interest in the developmental plasticity and therapeutic potential of stromal cells isolated from adipose tissue. Adipose-derived stem/stromal cells (ASCs) are multipotent somatic stem cells that are abundant in fat tissue. It has been shown that ASCs can differentiate into several lineages, including adipose cells, chondrocytes, osteoblasts, neuronal cells, endothelial cells, and cardiomyocytes. At the same time, adipose tissue can be harvested by a minimally invasive procedure, which makes it a promising source of adult stem cells. Therefore, it is believed that ASCs may become an alternative to the currently available adult stem cells (e.g. bone marrow stromal cells) for potential use in regenerative medicine. In this review, we present the basic information about the field of adipose-derived stem cells and their potential use in various applications.

Effect of substrate stiffness on differentiation of umbilical cord stem cells

61%

Witkowska-Zimny M., Walenko K., Walkiewicz A. E., Pojda Z., Przybylski J., Lewandowska-Szumiel M.

Acta Biochimica Polonica

2012

tom 59

nr 2

Tissue formation and maintenance is regulated by various factors, including biological, physiological and physical signals transmitted between cells as well as originating from cell-substrate interactions. In our study, the osteogenic potential of mesenchymal stromal/stem cells isolated from umbilical cord Wharton's jelly (UC-MSCs) was investigated in relation to the substrate rigidity on polyacrylamide hydrogel (PAAM). Osteogenic differentiation of UC-MSCs was enhanced on stiff substrate compared to soft substrates, illustrating that the mechanical environment can play a role in differentiation of this type of cells. These results show that substrate stiffness can regulate UC-MSCs differentiation, and hence may have significant implications for design of biomaterials with appropriate mechanical properties for regenerative medicine.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Cellular and Molecular Biology Letters

2 Walenko K.

2 Witkowska-Zimny M.

1 Lewandowska-Szumiel M.

1 Pojda Z.

1 Przybylski J.

1 Walkiewicz A. E.

1 2012

1 2011

Wyniki wyszukiwania

Stem cells from adipose tissue

Effect of substrate stiffness on differentiation of umbilical cord stem cells