ADN-1319 is a new indoloamine analogue of aripiprazole which displays antipsychotic-like properties in mouse models of psychosis, i.e. MK-801- and amphetamine-induced locomotor hyperactivity. In order to examine its potential antidepressant and anxiolytic activity, the forced swim test, and the four-plate and the marble burying tests, respectively, in mice were performed and a minimum effective dose is presented. ADN-1319 (2.5 mg/kg) significantly decreased the immobility time. Moreover, it increased the number of punished crossings (5 mg/kg) and reduced (10 mg/kg) the number of buried marbles. ADN-1319 up to a dose of 10 mg/kg had no influence on spontaneous locomotor activity in mice. Obtained data suggest that the tested compound displays specific antidepressant- and anxiolyticlike properties in mice and might find an application in treatment of symptoms of depression, anxiety or obsessive–compulsive behavior concomitant in schizophrenia.
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