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1

Evaluation of bone formation in fetal skeletons following prenatal paracetamol administration in single alizarin-stained specimens in Wistar rats

100%

Burdan F.

Folia Morphologica

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2000

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tom 59

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nr 3

The study was undertaken to evaluate the effect of paracetamol on skeleton in Wistar rats. The drug was administered orally, once a day, in three doses: P1 — 3.5 mg/kg, P2 — 35.0 mg/kg, P3 — 350.0 mg/kg. The foetuses were delivered by laparotomy on the 21st day of pregnancy and fixed in alcohol. The skeletons were stained with alizarin. Insignificant differences of bone malformations were found.

2

Somatic and skeleton development of rat foetuses following in-utero exposure to isopropylantipyrine [propyphenazone] during the second trimester of gestation

100%

Burdan F.

Folia Morphologica

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2000

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tom 59

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nr 4

Isopropylantipyrine (IPA, propyphenazone) is a pyrazolone derivative, widely used as an antipyretic and analgesic drug. The aim of the study was to evaluate the influence of propyphenazone on rat development. IPA was administered to pregnant rats from day 8 to day 14 of pregnancy once a day, orally by a stomach tube at doses of 2.10 (R1), 21.0 (R2), and 210.0 mg/kg/day (R3). The dams were sacrificed on day 21 of gestation and corpora luteum, implants, resorptions, and live foetuses were counted. The weight of foetuses and placentas, the length of foetuses and their tails were checked. The foetuses were fixed in alcohol and skeletons were stained with alizarin. There was a statistical difference in body length in R1, R2 and numbers of subcutaneous ecchymose in R1. External and skeletal examination of the foetuses revealed no evidence of teratogenesis. It can be concluded that IPA has no harmful effects on the prenatal development of the rat offspring at doses used in the present study.

3

The temperature of caffeine administered during pregnancy and foetal morphometric parameters

51%

Tomaszewski M., Burdan F., Olchowik G., Tomaszewska M.

Folia Morphologica

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2014

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tom 73

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nr 3

Background: Caffeine is one of the most frequently ingested (at various temperatures) xenobiotics by people. A number of studies have confirmed the negative effect of high doses of caffeine ingested during pregnancy both for the mother and the developing foetus. The aim of this study was to evaluate the relationship between caffeine’s toxicity on development and the administered solution’s temperature. Materials and methods: The research was conducted on rats. The fertilised females were randomly divided into two main groups: an experimental (E) and a control group (C). The experimental groups received caffeine (30 mg/day) in 10 (E1), 25 (E2) and 45°C (E3). The females in the control group were given water at the same temperature (C₁, C₂ and C₃). On the 21st day of pregnancy, the pregnant females were killed by decapitation using a specially prepared laboratory guillotine and were assessed morphometric parameters of foetuses. Results and Conclusions: Based on this work showed that: the embryotoxic effect of caffeine was only confined to a reduction in the number of offspring; the greatest changes in the morphometric parameters occurred in foetuses whose mothers received caffeine at 10°C; in the control groups, the greatest changes were observed in foetuses whose mothers were given water at 10°C during pregnancy. (Folia Morphol 2014; 72, 3: 347–352)

4

Blue nevus of the endocervix

51%

Szumilo J., Patel A., Patel S., Burdan F.

Folia Morphologica

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2010

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tom 69

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nr 1

The mucosa of the uterine cervix is normally devoid of melanocytes; therefore, melanin-containing lesions are very rare in this site. A new case of a common blue nevus in the cervix of a 57-year-old woman is reported. The lesion was an incidental finding in a total hysterectomy specimen performed for atypical endometrial hyperplasia. Gross and histological examination revealed minute dark macula on the mucosa of the posterior aspect of the endocervical canal, composed of loose conglomerates of spindle-shaped and dendritic cells located superficially within the stroma, containing multiple brownish granules, which exhibited positive immunostaining for HMB45 and melan A. Although the blue nevi seem to be lesions of low clinical significance, they require careful differential diagnosis with malignant melanoma, especially in scanty endocervical curettage or cervical biopsy specimens. (Folia Morphol 2010; 69, 1: 62–64)

5

Sebaceous gland - unusual histological finding in the uterine cervix

51%

Szumilo J., Patel A., Patel S., Burdan F.

Folia Morphologica

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2009

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tom 68

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nr 4

287-289

Sebaceous glands have been extremely rare findings in the female genital system. Excluding the vulva and recent findings, very few cases have been described. The origin of the lesions remains a topic of speculation. However, it appears that prolonged irritation induces a metaplastic response in the ectocervical epithelium. A new case of sebaceous glands in the ectocervix of a 46-year-old woman is reported. The lesions were unexpectedly found in a hysterectomy specimen. The procedure was carried out for multiple leiomyomas of the uterine corpus. Histological examination revealed three mature sebaceous glands located distally to the transformation zone, which opened directly onto the surface epithelium. It could be concluded that sebaceous glands in the ectocervix are rare lesions of unclear origin and low clinical significance. However, the glands could potentially be associated with sebaceous carcinoma of that anatomical site. (Folia Morphol 2009; 68, 4: 287–289)

6

Intrapancreatic accessory spleen

51%

Szumilo J., Fronczek A., Bukharin S., Burdan F.

Folia Morphologica

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2012

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tom 71

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nr 1

A case of accessory spleen located in the tail of the pancreas in a stillbirth male foetus is reported. The congenital anomaly was revealed at autopsy. The intrapancreatic spleen was well demarcated and was composed of red and white pulp; however, same pancreatic ducts were intermingled with the splenic parenchyma. As well as the intrapancreatic lesion another minute accessory spleen was also found at the hilum of the proper organ. Since a lack of morphological features of trisomy 13 syndrome were found in the foetus, the ectopic spleens were regarded as incidental findings. (Folia Morphol 2012; 71, 1: 45–47)

7

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The effects of caffeine administered at different temperatures on foetal development

51%

Tomaszewski M., Burdan F., Olchowik G., Tomaszewska M.

Annals of Agricultural and Environmental Medicine

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2016

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tom 23

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nr 1

8

Use of X-ray microprobe to diagnose bone tissue demineralization after caffeine administration

51%

Tomaszewski M., Olchowik G., Tomaszewska M., Burdan F.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 3

9

Morphology of third molar teeth with incompletely formed apices on the basis of panoramic radiograms

51%

Rozylo-Kalinowska I., Burdan F., Marchut T.

Folia Morphologica

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2003

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tom 62

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nr 2

Third molar teeth are causative factors of many oral pathologies. Lower third molars are the most often retained teeth and the origin of considerable pain. The aim of the study is a presentation of the morphology of third molars with incompletely formed apices on the basis of panoramic radiograms. The material comprised routine panoramic radiograms taken in the years 1996–2000. In the cases where third molars with incompletely formed apices were found, there was determined the location of the teeth in the alveolar process. The angle between occlusal plane and tooth axis was measured, which allowed determination of angularity of the teeth. Retromolar space width ratio was also calculated as a prognostic radiographic feature on which an estimation of future eruption of mandibular third molars could be based. In retained teeth the reasons for impaction, such as incorrect angularity, insufficient retromolar space, presence of pathological lesions impeding eruption, were analysed. Panoramic radiograms proved useful in diagnostics of morphology of third molars with incompletely formed apices.

10

Activity of some lysosomal enzymes in adrenal cortex during experimental alloxan-induced diabetes mellitus in rabbits

45%

Grzebalska A. M., Cendrowska-Pinkosz M., Luszczewska-Sierakowska I., Burdan F., Krauze M.

Medycyna Weterynaryjna

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2014

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tom 70

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nr 04

The aim of the study was the evaluation of changes in the adrenal cortex lysosomal enzymes activity during experimental alloxan-induced diabetes mellitus in rabbits. We checked the activity of acid phosphatase, β-D-galactosidase, N-acetyl-β-D-glucosaminidase (NAGL) and lipase. The study was performed on 124 rabbits divided into five groups: one control and four experimental. Diabetes mellitus was induced by a single injection of 10% alloxan solution into the auricular vein in a dose of 10 mg per kg body weight. Animals from experimental groups were killed in the 21st, 42nd, 90th and 180th days of the study. Adrenal glands were removed. Enzymes activity was assayed by spectrophotometric methods. Changes in free and bound fractions of examined lysosomal enzymes activity were noticed already in the 21st day of diabetes. The most escalated changes were observed in the 42nd day of the study. Performed statistical variance analysis demonstrated statistically highly significant differences for activity of both fractions of NAGL and lipase, as well as for free fraction activity of acid phosphatase and β-D-galactosidase. The obtained data confirmed the influence of diabetes mellitus on changes in the activity of examined lysosomal enzymes in the adrenal cortex.

11

The influence of caffeine administered at 10°C on bone tissue development

45%

Tomaszewski M., Olchowik G., Tomaszewska M., Dworzanski W., Burdan F.

Annals of Agricultural and Environmental Medicine

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2016

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tom 23

|

nr 2

12

Diet supplements, resveratrol and protocatechuic acid, do not disturb wellness and liver morphology in rats

45%

Szumilo J., Fraczek M., Klepacz R., Szumilo M., Burdan F.

Medycyna Weterynaryjna

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2015

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tom 71

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nr 05

The aim of the study was to evaluate the influence of a prolonged administration of two natural compounds – resveratrol (20 ppm) and protocatechuic acid (2000 ppm) – on the health status of Wistar rats. The animals were kept on supplemented diets for 7 and 24 weeks. Body weight was assessed weekly, and liver weight during autopsy. Liver morphology was evaluated histologically. The body weight in the 24th week, body weight gain (between the 1st and the 24th week of the experiment), and liver weight were significantly higher for the animals kept on the diet including resveratrol throughout the experiment than for those that had received this diet during the initial 7 weeks. However, differences in these parameters, as well as in the relative liver weight, between the control group and the groups exposed to both compounds were insignificant. Occasionally, mild, mostly reversible, microscopic hepatic changes (i.e., hydropic and fatty changes) were found, and these were slightly more common in the groups kept on supplemented diets. It seems that resveratrol and protocatechuic acid did not significantly disturb the wellness of rats, even after prolonged exposure.

13

Anatomical eponyms - unloved names in medical terminology

45%

Burdan F., Dworzanski W., Cendrowska-Pinkosz M., Burdan M., Dworzanska A.

Folia Morphologica

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2016

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tom 75

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nr 4

Uniform international terminology is a fundamental issue of medicine. Names of various organs or structures have developed since early human history. The first proper anatomical books were written by Hippocrates, Aristotle and Galen. For this reason the modern terms originated from Latin or Greek. In a modern time the terminology was improved in particular by Vasalius, Fabricius and Harvey. Presently each known structure has internationally approved term that is explained in anatomical or histological terminology. However, some elements received eponyms, terms that incorporate the surname of the people that usually describe them for the first time or studied them (e.g., circle of Willis, follicle of Graff, fossa of Sylvious, foramen of Monro, Adamkiewicz artery). Literature and historical hero also influenced medical vocabulary (e.g. Achilles tendon and Atlas). According to various scientists, all the eponyms bring colour to medicine, embed medical traditions and culture to our history but lack accuracy, lead of confusion, and hamper scientific discussion. The current article presents a wide list of the anatomical eponyms with their proper anatomical term or description according to international anatomical terminology. However, since different eponyms are used in various countries, the list could be expanded. (Folia Morphol 2016; 75, 4: 413–438)

14

The effects of short-time caffeine administration on skeleton development in Wistar rats

45%

Burdan F., Madej B., Wojtowicz Z., Maciejewski R., Radzikowska E.

Folia Morphologica

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2000

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tom 59

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nr 2

15

Temporary elevation of pancreatic lysosomal enzymes, as a result of the omeprazole-induced peripancreatic inflammation in male Wistar rats

45%

Burdan F., Siezieniewska Z., Maciejewski R., Burski K., Wojtowicz Z.

Journal of Physiology and Pharmacology

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2000

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tom 51

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nr 3

16

The activity of cortical lysosomal enzymes after long-term application of antagonists of H2 receptor

39%

Burdan F., Maciejewski R., Wojtowicz Z., Wyskiel M., Burak B., Burski K.

Acta Neurobiologiae Experimentalis

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1999

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tom 59

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nr 3

17

Influence of caffeine administered at 45 degrees Celsius on bone tissue development

39%

Tomaszewski M., Olchowik G., Tomaszewska M., Dworzanski W., Panczuk A., Burdan F.

Annals of Agricultural and Environmental Medicine

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2014

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tom 21

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nr 4

18

Aktywnosc dehydrogenazy mleczanowej ludzkich erytrocytow w obecnosci wybranych inhibitorow dehydrogenazy alkoholowej

39%

Dudka J., Burdan F., Madej B., Tokarska E., Klepacz R., Korobowicz E.

Roczniki Państwowego Zakładu Higieny

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2004

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tom 55

|

nr 3

229-234

W pracy oceniono wpływ cymetydyny, EDTA, 4-metylopirazolu oraz etanolu i metanolu na aktywność dehydrogenazy mleczanowej. Badania przeprowadzono in vitro z enzymem otrzymanym z erytrocytów ludzkich.

19

Anatomical variances and dimensions of the superior orbital fissure and foramen ovale in adults

39%

Burdan F., Umlawska W., Dworzanski W., Klepacz R., Szumilo J., Staroslawska E., Drop A.

Folia Morphologica

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2011

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tom 70

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nr 4

The aim of the study was the retrospective morphological analysis of selected structures of the middle cranial fossa, i.e. foramen ovale and superior orbital fissure, in relation to the external head and cranial diameters in adults from the Lublin region (Poland). The study was performed on data collected during computed tomography examinations of 60 individuals (age 20–30 years), without any cranial or brain abnormalities. Based on the post-processing reconstructions, 3-dimensional views of the skull and head were obtained. The length and width of both structures, as well as thickness of the frontal, temporal, and occipital squamae, were measured. The morphology of the ovale foramina and superior orbital fissures were checked. The length and width of the skull and head were the only parameters that significantly differed between males and females. The thickness of the frontal and temporal squama was insignificantly lower in males than in females. Almond and oval shapes were the most typical for the foramen ovale. The superior orbital fissure was found as a wide form — with or without accessory spine originating from its lower margin or as a laterally narrowed form. The length and width of the foramen ovale were insignificantly higher in males than in females. The same results were found for the area of the right superior orbital fissure. The thickness of the frontal and occipital squamae influenced the thickness of the temporal squama. The analysed individuals had asymmetrical, oval, or almond-shape ovale foramina. Unlike the seldom visible laterally narrowed form of the superior orbital fissure, a wide form with or without accessory spine was the most commonly observed. The diameters of both superior orbital fissures and ovale foramina indicated the asymmetry of the neurocranium. (Folia Morphol 2011; 70, 4: 263–271)

20

The activity and immunoexpression of cathepsin D in rat male reproductive organs

39%

Burdan F., Szumilo J., Dudka J., Dabrowski A., Maciejewski R., Wojtowicz Z.

Folia Morphologica

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2006

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tom 65

|

nr 2

111-115

Cathepsin D is a cysteine endopeptidase that belongs to the lysosomal enzyme family. The aim of the study was to evaluate the enzyme immunoexpression and activity in selected male genital organs in mature Wistar rats. The activity of cathepsin D was measured spectrophotometrically in homogenates of the testis, epididymis, seminal vesicle and prostate. Immunohistochemical staining was also performed in the ductus deferens. Enzyme activity was found in the following sequence: testis>epididymis>dorsal prostatic lobe>seminal vesicle>lateral prostatic lobe>ventral prostatic lobe. Although there were differences in enzyme activity between various organs of the male reproductive system, cathepsin D immunoreactivity was seen exclusively in the Sertoli and Leydig cells in the testis.

Ograniczanie wyników

Evaluation of bone formation in fetal skeletons following prenatal paracetamol administration in single alizarin-stained specimens in Wistar rats

Somatic and skeleton development of rat foetuses following in-utero exposure to isopropylantipyrine [propyphenazone] during the second trimester of gestation

The temperature of caffeine administered during pregnancy and foetal morphometric parameters

Blue nevus of the endocervix

Sebaceous gland - unusual histological finding in the uterine cervix

Intrapancreatic accessory spleen

The effects of caffeine administered at different temperatures on foetal development

Use of X-ray microprobe to diagnose bone tissue demineralization after caffeine administration

Morphology of third molar teeth with incompletely formed apices on the basis of panoramic radiograms

Activity of some lysosomal enzymes in adrenal cortex during experimental alloxan-induced diabetes mellitus in rabbits

The influence of caffeine administered at 10°C on bone tissue development

Diet supplements, resveratrol and protocatechuic acid, do not disturb wellness and liver morphology in rats

Anatomical eponyms - unloved names in medical terminology

The effects of short-time caffeine administration on skeleton development in Wistar rats

Temporary elevation of pancreatic lysosomal enzymes, as a result of the omeprazole-induced peripancreatic inflammation in male Wistar rats

The activity of cortical lysosomal enzymes after long-term application of antagonists of H2 receptor

Influence of caffeine administered at 45 degrees Celsius on bone tissue development

Aktywnosc dehydrogenazy mleczanowej ludzkich erytrocytow w obecnosci wybranych inhibitorow dehydrogenazy alkoholowej

Anatomical variances and dimensions of the superior orbital fissure and foramen ovale in adults

The activity and immunoexpression of cathepsin D in rat male reproductive organs