For this study we investigated 2 series compounds by 2 waste materials – rock flour and tire crumbs – for use as barrier liner material. The first series used marble rock flour-clay (RF-C) mixture and the second used series clay soil-tire crumb (C-TC) mixture. The compounds were mixed, compacted, and tested for diffusion and permeability. The obtained diffusion coefficients (predicted and observational data) were compared with the recommended diffusion coefficient for a compacted clayey liner. The results of research showed that the compounds contain maximum 50% RF and 40% TC in the first and second series, respectively. Due to the presence of a sufficient amount of clay minerals, it has an appropriate ion absorption property that is necessary for landfill liner. Then the permeability of compounds in various pressures was determined. The obtained permeability are in the range of values recommended for the compacted clayey liners, and therefore this material is acceptable in terms of molecular diffusion and permeability. It could be said the compression capability and adsorption characteristic of this material are comparable to clayey liners, and this material could be recommended as an alternative material for landfill liner construction.