The investigation were carried out with 50 cows in the experimental farms of the Agricultural University in Wrocław and with 48 cows in German farms served by the Veterinary Polyclinic in Tellingstedt. Each cow with purulent endometritis was treated with an intrauterine infusion of 2% Vagothyl. Cows in experimental groups (DW and DT) were administered with 50 mg Propranolol. Before treatment, each animal was rectally investigated to find corpus luteum on the ovaries. The cows with corpus luteum were administered with PGF₂α After the treatment the vaginal discharges in experimental cows ceased after 7 days of therapy, which was shorter than in control cows (14 and more days). Involution of the uterus was terminated after 28 to 35 days in experimental groups and after 42 and more days in the control group. Administration of Propranolol during purulent endometritis treatment allowed the interpregnancy period not to be prolonged.