Wyniki wyszukiwania

1

Udzial cytokin i innych mediatorow w procesie gojenia rany

100%

Kocik J.

Postępy Biologii Komórki

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1996

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tom 23

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nr 1

63-82

2

Biotechnologia a bioterroryzm - jak nie zepsuc dobroczynnych owocow badan nad organizmami zmodyfikowanymi

100%

Kocik J.

Kosmos

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2007

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tom 56

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nr 3-4

233-236

3

Biological agents database in the armed forces

51%

Niemcewicz M., Kocik J., Bielecka A., Wiercinski M.

Archivum Immunologiae et Therapiae Experimentalis

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2014

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tom 62

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nr 5

4

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

New aspects of the infection mechanisms of B. anthracis

45%

Zakowska D., Bartoszcze M., Niemcewicz M., Bielawska-Drozd A., Kocik J.

Annals of Agricultural and Environmental Medicine

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2012

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tom 19

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nr 4

5

Antiviral activity of novel oseltamivir derivatives against some influenza virus strains

45%

Kocik J., Kolodziej M., Joniec J., Kwiatek M., Bartoszcze M.

Acta Biochimica Polonica

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2014

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tom 61

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nr 3

6

Research on prevention and treatment of hemorrhagic fevers

45%

Joniec J., Kolodziej M., Bartoszcze M., Kocik J., Knap J.

Annals of Agricultural and Environmental Medicine

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2012

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tom 19

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nr 2

Viral hemorrhagic fevers are severe zoonotic diseases caused by RNA-viruses classified into 4 families: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. They are present on all continents except Antarctica, their person-to-person spread is easy, and there is a high risk of them being used as weapon by bioterrorists. So far, efforts to develop effective drugs against these viruses have failed, and typical therapy usually relies on symptomatic treatment. Search for substances that could effectively inhibit this type of infections is now a priority. The presented paper gives an overview of different approaches used in combating the viral hemorrhagic fevers. Researchers look for safe antiviral agents with appropriate properties among natural sources, such as various types of herbs plants, algae, or essential oils obtained from trees, as well as investigate the use of various synthetic substances. The aim is to broaden the pool of available antiviral drugs that could replace hitherto applied medicines such as ribavirin, which is not always sufficiently effective and may have side-effects. The scientists focus not only on combating the diseases, but also on their prevention. For this purpose, recombinant vaccines or various types of immunomodulators may serve as a useful tools. Results of the latest studies are promising and encourage further work which may eventually lead to the solution of the urgent problem of hemorrhagic fevers.

7

Nastepny bedzie wirus?

44%

Kocik J.

Wiedza i Życie

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2001

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nr 11

14-17

8

Microarrays - new possibilities for detecting biological factors hazardous for humans and animals, and for use in environmental protection

39%

Mirski T., Bartoszcze M., Bielawska-Drozd A., Gryko R., Kocik J., Niemcewicz M., Chomiczewski K.

Annals of Agricultural and Environmental Medicine

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2016

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tom 23

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nr 1

9

In vivo inhibitory effect of Aloe vera gel on the ability of mouse parental splenic lymphocytes to induce cutaneous angiogenesis in recipient F1 mice

39%

Skopinski P., Lewicki S., Balan B. J., Kocik J., Zdanowski R., Skopinska-Rozewska E., Siwicki A. K.

Polish Journal of Veterinary Sciences

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2014

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tom 17

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nr 1

Lymphocyte-induced angiogenesis test (LIA) is a model of local graft-versus-host (GVH) reaction, marker of the earliest events resulting from activation of donor lymphocytes after contact with host semi-allogeneic histocompatibility antigens. The effect of in vivo oral administration of Aloe vera gel for 21 days to maternal strain (Balb/c) donor mice on the ability of their splenic lymphocytes to induce cutaneous angiogenesis (LIA test) in F1 Balb/c x C3H recipients, was studied. Results: Neovascular reaction evaluated 72 hours after cells grafting was significantly lower in F1 mice grafted with lymphocytes collected from Aloe- fed donors, than in recipients of lymphocytes collected from respective controls. Conclusions: This observation opens the promise of safe and ethically acceptable possibility of use of Aloe vera gel in human donors in prevention of GVHD in recipients of bone marrow grafts.

10

Research on substances with activity against orthopoxviruses

39%

Kolodziej M., Joniec J., Bartoszcze M., Gryko R., Kocik J., Knap J.

Annals of Agricultural and Environmental Medicine

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2013

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tom 20

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nr 1

Although smallpox was eradicated over 30 years ago, the disease remains a major threat. High mortality, high infectivity and low resistance of the contemporary population make the smallpox virus very attractive to terrorists. The possible presence of illegal stocks of the virus or risk of deliberate genetic modifications cause serious concerns among experts. Hence, it is reasonable to seek effective drugs that could be used in case of smallpox outbreak. This paper reviews studies on compounds with proven in vitro or in vivo antipoxviruses potential, which show various mechanisms of action. Nucleoside analogues, such as cidofovir, can inhibit virus replication. Cidofovir derivatives are developed to improve the bioavailability of the drug. Among the nucleoside analogues under current investigation are: ANO (adenozine N1-oxide) and its derivatives, N-methanocarbothymidine [(N)-MCT], or derivatitives of aciklovir, peninclovir and brivudin. Recently, ST-246 – which effectively inhibits infection by limiting release of progeny virions – has become an object of attention. It has been also been demonstrated that compounds such as: nigericin, aptamers and peptides may have antiviral potential. An interesting strategy to fight infections was presented in experiments aimed at defining the role of individual genes (E3L, K3L or C6L) in the pathogenesis, and looking for their potential blockers. Additionally, among substances considered to be effective in the treatment of smallpox cases, there are factors that can block viral inhibitors of the human complement system, epidermal growth factor inhibitors or immunomodulators. Further studies on compounds with activity against poxviruses are necessary in order to broaden the pool of available means that could be used in the case of a new outbreak of smallpox.

11

Novel strategies of PD-1/PD-L1 immune checkpoint blockade for cancer therapy: antibodies, peptides and small molecules

39%

Skalniak L., Kocik J., Magiera K., Guzik K., Musielak B., Holak T. A.

Acta Biochimica Polonica

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2018

|

tom 65

|

nr S2

12

Bacillus anthracis infections – new possibilities of treatment

33%

Zakowska D., Bartoszcze M., Niemcewicz M., Bielawska-Drozd A., Knap J., Cieslik P., Chomiczewski K., Kocik J.

Annals of Agricultural and Environmental Medicine

|

2015

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tom 22

|

nr 2

13

Review of methods used for identification of biothreat agents in environmental protection and human health aspects

33%

Mirski T., Bartoszcze M., Bielawska-Drozd A., Cieslik P., Michalski A. J., Niemcewicz M., Kocik J., Chomiczewski K.

Annals of Agricultural and Environmental Medicine

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2014

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tom 21

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nr 2

14

Evaluation of the levels and quality of microbial contamination in medical emergency departments in comparison to other workplaces

33%

Bielawska-Drozd A., Wlizlo-Skowronek B., Cieslik P., Winnicka I., Skopinska-Rozewska E., Kubiak L., Zakowska D., Brewczynska A., Kocik J.

Polish Journal of Microbiology

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2016

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tom 65

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nr 4

Work in Hospital Emergency Departments (HEDs) exposes both the emergency ward staff and patients to infectious and in other way harmful biological agents. The results of this study shows the presence of pathogenic bacteria isolated by three different methods. It revealed 9.8% of pathogens detected by imprint method, 10.5% of pathogens by swabbing method, 17.6% and 22% in HEDs corridors and rooms, respectively, by air sampling method. In control workplaces (offices) pathogenic bacteria reached the level of 6.5% and 14.7% by imprint method and swabbing, respectively. The relatively low level of contamination by bacteria in HEDs may depend on the effectiveness of Standard Protective Precautions in the studied hospitals.

15

Acute respiratory distress syndrome (ARDS) in the course of influenza A/H1N1v infection – genetic aspects

27%

Niemcewicz M., Pajak B., Michalski A., Kocik J., Kolodziej M., Joniec J., Graniak G., Gawel J., Marciniak-Niemcewicz A., Kucharczyk K., Prystupa A., Witczak A., Lasocki K., Naylor K., Goniewicz M.

Annals of Agricultural and Environmental Medicine

|

2013

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tom 20

|

nr 4

16

Acute respiratory distress syndrome (ARDS) complicating influenza A/H1N1v infection – a clinical approach

27%

Witczak A., Prystupa A., Kurys-Denis E., Borys M., Czuczwar M., Niemcewicz M., Kocik J., Michalak A., Pietrzak A., Chodorowska G., Krupski W., Mosiewicz J., Tamasiewicz K.

Annals of Agricultural and Environmental Medicine

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2013

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tom 20

|

nr 4

17

Severe Influenza Outbreak in Western Ukraine in 2009 – a molecular-epidemiological study

27%

Kocik J., Niemcewicz M., Johns M., Jerke K., Michalski A., Bielecka A., Lasocki K., Gawel J., Bielawska-Drozd A., Joniec J., Kolodziej M., Graniak G., Goniewicz M., Kubiak L.

Annals of Agricultural and Environmental Medicine

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2013

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tom 20

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nr 3

Introduction: In the autumn of 2009 the authors participated in a humanitarian operation in Western Ukraine by undertaking an epidemiological investigation of an influenza-like-illness (ILI) in the L’viv Oblast region. Mobile biological survey teams took samples from civilian patients with severe acute respiratory distress syndrome, rapid transportation of the samples, and their molecular analysis in Poland to provide accurate results. Objective: The aim of the study was the molecular and epidemiological analysis of the biological samples collected. Material and Methods: Real-time reverse transcriptase polymerase chain reaction (real-time RT-PCR), multiplex PCR techniques, traditional Sanger Sequencing and classical viral culture methods were used. Results: Among the 124 influenza-like illness cases, ~50% (58) were positive for influenza A virus in WHO-CDC molecular assay, including subtyping. The specimens were further analyzed to confirm results and determine the genetic sequence. Phylogenetically, the nucleotide similarity of both the Ukraine specimens and reference A/California/7/2009 (pH1N1) was 99.2–99.3%. Oseltamivir resistance was not registered. HA1 region characterization showed an overall protein identity of 98.5–99.4%. Conclusions: An unexpected high contribution of influenza A was confirmed among ILI patients, as well as a very limited number of other detected viruses, indicate that the 2009 epidemic in western Ukraine was strongly related to novel influenza A/H1N1. The importance of swift sharing of information and reference laboratories networking in surveillance, as well as serving governments and international agencies in pursuing adequate actions, should be stressed.

18

Microbiological analysis of bioaerosols collected from Hospital Emergency Departments and ambulances

27%

Bielawska-Drozd A., Cieslik P., Bohacz J., Kornillowicz-Kowalska T., Zakowska D., Bartoszcze M., Wizlo-Skowronek B., Winnicka I., Brytan M., Kubiak L., Skopinska-Rozewska E., Kocik J.

Annals of Agricultural and Environmental Medicine

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2018

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tom 25

|

nr 2

19

Diversity of influenza - like illness etiology in Polish Armed Forces in influenza epidemic season

27%

Kocik J., Niemcewicz M., Winnicka I., Michalski A., Bielawska-Drozd A., Kolodziej M., Joniec J., Cieslik P., Graniak G., Mirski T., Gawel J., Bielecka-Oder A., Kubiak L., Russell K.

Acta Biochimica Polonica

|

2014

|

tom 61

|

nr 3

Ograniczanie wyników

Udzial cytokin i innych mediatorow w procesie gojenia rany

Biotechnologia a bioterroryzm - jak nie zepsuc dobroczynnych owocow badan nad organizmami zmodyfikowanymi

Biological agents database in the armed forces

New aspects of the infection mechanisms of B. anthracis

Antiviral activity of novel oseltamivir derivatives against some influenza virus strains

Research on prevention and treatment of hemorrhagic fevers

Nastepny bedzie wirus?

Microarrays - new possibilities for detecting biological factors hazardous for humans and animals, and for use in environmental protection

In vivo inhibitory effect of Aloe vera gel on the ability of mouse parental splenic lymphocytes to induce cutaneous angiogenesis in recipient F1 mice

Research on substances with activity against orthopoxviruses

Novel strategies of PD-1/PD-L1 immune checkpoint blockade for cancer therapy: antibodies, peptides and small molecules

Bacillus anthracis infections – new possibilities of treatment

Review of methods used for identification of biothreat agents in environmental protection and human health aspects

Evaluation of the levels and quality of microbial contamination in medical emergency departments in comparison to other workplaces

Acute respiratory distress syndrome (ARDS) in the course of influenza A/H1N1v infection – genetic aspects

Acute respiratory distress syndrome (ARDS) complicating influenza A/H1N1v infection – a clinical approach

Severe Influenza Outbreak in Western Ukraine in 2009 – a molecular-epidemiological study

Microbiological analysis of bioaerosols collected from Hospital Emergency Departments and ambulances

Diversity of influenza - like illness etiology in Polish Armed Forces in influenza epidemic season