The objective of the study was to assess the effects of a high-fructose diet as opposed to a starch diet (standard or enriched, respectively) on oxidative stress indices in rats fed for 9 weeks. In some groups of the animals, fructose overload diminished cellular glutathione peroxidase (GPX1) activity in the liver, while in others, the enrichment of diet with buckwheat enhanced heart GPX1 activity. No change in GPX1 activity was detected in the testes. Similarly, different diets did not affect significantly either thioredoxin reductase (TR) in the testes and kidneys, or superoxide dismutase (SOD) activity of red blood cells. All study groups exhibited decreased malondialdehyde content in plasma and ferric reducing ability of plasma, as compared with control groups. Taken together, these findings support the hypothesis that a diet high in fructose significantly changes antioxidant defence status in rats, but it can be counteracted by the addition of an appropriate nutrient.
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