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1

It is said that "almost makes difference": are different strains of nice the same?

100%
Juszczak G.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
Both inbred (A/J, AKR, Balb/c, C3H, C57BL/6, DBA/2, FVB) and outbred (Swiss Webster, CD-1) strains of mice are commonly used in in vivo and in vitro experiments. Behavioral and pharmacological comparisons of different strains of mice revealed high variability in a number of behavioral parameters and in sensitivity to pharmacological treatments. Between-strain differences were observed in sensitivity to antidepressant drugs, morphine, MK-801, kainate and amphetamine. There are both highly sensitive strains and strains resistant to action of drugs. Less often are observed opposite reactions to pharmacological treatments. The genetic background is, therefore, an important factor contributing to variability of results obtained in different laboratories using different strains of mice. This problem is important not only in behavioral pharmacology but also in in vitro experiments and in genetic engineering.
2

The low-frequency oscillation model of hallucinations in neurodegenerative disorders and in delirium

100%
Juszczak G.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
Visual hallucinations in neurodegenerative disorders and in delirium are composed of fully developed objects of normal shape and size whereas fragmented or distorted objects and geometric patterns are uncommon. Usually, patients hallucinate other people or frightening animals whereas emotionally irrelevant objects are rarely hallucinated. Commonly, the same image repeats itself on different occasion and patients hallucinate one or very limited kinds of objects. The characteristic of hallucinations suggest that they result from activation of preexisting and shaped by experience neuronal representation of external objects. A consistent EEG finding in Parkinson’s and Alzheimer’s disease, dementia with Lewy Bodies, and in delirium is increased power in delta and theta frequencies with the degree of EEG slowing paralleling the frequency of occurrence of hallucinations. Therefore, I propose a theoretical model of hallucination that is based on current concepts in neuroscience and on electrophysiological findings in clinical and basic research. According to the proposed model the prolonged depolarization, associated with low-frequency oscillations, randomly activate neurons which, in turn, send impulses by forward and backward connections. It is expected that emotionally relevant objects are represented by networks with strongest synaptic connections and that the stronger object representation the higher probability that random activation of neurons will activate the entire network by means of reciprocal connections. Activated representation is further reinforced by attentional processes and enters the content of consciousness leading to hallucination. The proposed model explains the phenomenology of hallucinations occurring in neurodegenerative disorders and in delirium. The model can be also relevant for hypnagogic hallucinations experienced during the sleep onset and in schizophrenia.
3

Involvment of inhibitory skills in behaviour of mice subjected to detour test

63%
Juszczak G., Miller M.
Acta Neurobiologiae Experimentalis
|
2015
|
tom 75
|
nr Supl.
BACKGROUND AND AIMS: A common test of intelligence is the detour task, where various barriers are applied to prevent animals from reaching a goal. However, there is no information available about the effect of goal visibility on rodent behavior and about the involvement of inhibitory skills and physical cognition in performance of rodents faced with the detour problem. Therefore, we tested the effect of target visibility both in naïve mice and in subjects that already had an experience in detouring obstacles. METHODS: The subjects were F1 hybrid (C57BL10×CBA/H) male mice. The water escape paradigm was used to motivate mice to detour the barrier. The apparatus consisted of circular tank and visible platform. Transparent, semitransparent and opaque barriers were used to prevent animals from reaching their goal. RESULTS: We have found that naïve mice tested with transparent barrier displayed high level of perseveration. In contrast, mice that were initially trained with opaque or semitransparent barriers displayed no deficits during tasks applying transparent barrier. Improvement in both transparent and semitransparent groups was associated with changes in path direction. We have also found that mice displayed consistent lateralization during inward and outward detour trials. CONCLUSIONS: We have found that both inhibitory skills and physical cognition affects performance of mice subjected to the detour task. The difficulty to inhibit proponent responses interfered with the ability of mice to find the proper solution. We have also found that mice followed their respective left or right side instead of using landmarks to navigate during the test. Obtained results show for the first time that behavior of mice subjected to the detour task is comparable with the behavior of other species including human infants and monkeys.
4

Detour test in mice

51%
Kokocinska A., Juszczak G., Korwin M.
Acta Neurobiologiae Experimentalis
|
2014
|
tom 74
|
nr 3
A common test of intelligence is the detour test where a forward movement, motivated usually by a reward, is prevented by transparent barrier. In order to solve the task, the subject has to move initially away from the target and therefore the performance depends on the ability to inhibit the prepotent but ultimately counterproductive responses driven by visual stimulus. Up to date, detour abilities have been shown in different species including humans, monkeys and dingoes, but there is no rodent detour test applying transparent barrier. Therefore, we have developed a mouse detour test based on water-escape paradigm. Mice were first trained to swim toward the visible platform and next were tested to detour the V shaped glass barrier placed in front of the platform. We have found that mice from different strains are able to learn how to solve the task although there are between-subject and between-strain differences. We have also found that mice display behavioral lateralization in the detour test.
5

Zachowanie chorobowe - nowe pojecie w biologii

51%
Swiergiel A. H., Sacharczuk M., Juszczak G., Wolak P.
Wszechświat
|
2004
|
tom 105
|
nr 10-12
250-254
6

Effect of MK-801 and lipopolysaccharide on acoustic startle refiex in mice selected for high and Iow stress-induced analgesia

45%
Juszczak G., Blaszczyk J. W., Sliwa A., Wolak P. M., Swiergiel A. H.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 3
7

Effect of metabolic rate on the rate of elimination of high and low concetrations of cadmium and lead in the bank vole

39%
Sawicka-Kapusta K., Gorecki A., Swiergosz R., Juszczak G., Mielczarek M., Wojcik B.
Ekologia Polska
|
1987
|
tom 35
|
nr 2
8

Alcohol reverses depressive and pronociceptive effects of chronic stress in mice with enhanced activity of the opioid system

39%
Sacharczuk M., Juszczak G., Swiergiel A. H., Jaszczak K., Lipkowski A. W., Sadowski B.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 4
The role of the opioid system in mediating effects of alcoholism and stress in depression is far from clear. We studied, therefore, the effects of chronic mild stress (CMS) and alcohol drinking on depression-like behavior and nociception in lines of mice selected for high (HA) or low (LA) swim stress-induced analgesia. Compared to the LA mice, the HA animals display up-regulation of opioid receptor system function and depression-like behavior in tail suspension test (TST). We report now that alcohol reverses depressive and pronociceptive effect of CMS in HA mice. In contrast, in LA mice CMS does not affect nociception or behavior in TST and the animals are not susceptible to alcohol under CMS. The results suggest that opioid system activity may determine the effects of alcohol on behavior under stress and, therefore, link predispositions to depression and to alcoholism.
9

Effect of acute and repeated social stress on hippocampal transcriptome in mice

33%
Stankiewicz A., Zabielska J., Milewczyk A., Korowin M., Gasiorkiewicz I., Swiergiel A., Juszczak G., Lisowski P.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
The aim of the study was to investigate dynamics of transcriptomic changes in hippocampus during stress in correlation with behavioral and physiological symptoms of acute and chronic stress response. Male Swiss Webster mice were subjected to repeated social stress and decapitated after 1, 4, 8, and 13 days of repeated encounters with other male mice. There was also a group of mice subjected to 13 days of social stress and then left without stress for 5 days. Acute stress induced decrease in food intake and in body weight. Repeated stress induced thymic involution progressing with increasing duration of stress and significant increase in spleen weight, was observed after 13 days of stress. In mice subjected to stress and then left for 5 days for recovery the spleen weight did not differed from control mice and there was partial recovery of thymic weight. During the recovery period there was also increased food intake compared with control mice. Using microarray and quantitative real-time PCR technologies we found that social stress affected hippocampal transcription of genes involved in pathways of insulin secretion, intracellular signaling and cellular transport. Among them, during subsequent time points of social stress we observed progressive upregulation of Ttr gene coding transthyretin involved in amyloidosis, seizures, or dementia and prolactin receptor – Prlr, involved in anxiolyting effects at brain level. The results show that repeated stress provokes major changes in hippocampal physiological pathways. Effects of stress on expression of genes involved in insulin signalling and cellular transport indicate that stress may affect the CNS structure and produce the long-term and irreversible changes in the CNS functions.
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