This article deals with total waste separation in the frame of a concrete region in Slovakia. The goal of the contribution is to use logistics, modelling, and simulation for the needs of total waste separation and liquidation to the way raw material and usable sources for new use in practice. Results of the simulation show that by total separation and waste recycling in the frame of the concrete analysed region it is possible to produce during the whole year approximately 390,000 m³ of biogas, and it is possible to obtain approximately €9.3 million per year, which can be used for developing complex recycling systems in the region.