Wyniki wyszukiwania

1

Bialka wiazace GTP jako uniwersalny przekaznik sygnalow

100%

Adler G.

Postępy Biologii Komórki

|

1995

|

tom 22

|

nr 2

103-111

2

Udział białek wiążących nukleotydy guanylowe w hormonalnej regulacji cyklazy adenylowej

100%

Adler G.

Postępy Biochemii

|

1982

|

tom 28

|

nr 4

3

Tyreoliberyna

63%

Adler G.

Postępy Biochemii

|

1977

|

tom 23

|

nr 1

4

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

The analgesic efficacy of kinesiology taping in delayed Onset Muscle Soreness (DOMS)

51%

Kruszyniewicz J., Skonieczna-Zydecka K., Sroka R., Adler G.

Central European Journal of Sport Sciences and Medicine

|

2016

|

tom 13

|

nr 1

5

Allele frequency distribution of 1691G>A F5 (which confers Factor V Leiden) across Europe, including Slavic populations

51%

Clark J. S. C., Adler G., Salkic N. N., Ciechanowicz A.

Journal of Applied Genetics

|

2013

|

tom 54

|

nr 4

6

Concentrations of heavy metals (Mn, Co, Ni, Cr, Ag, Pb) in coffee

39%

Nedzarek A., Torz A., Karakiewicz B., Clark J. S., Laszczynska M., Kaleta A., Adler G.

Acta Biochimica Polonica

|

2013

|

tom 60

|

nr 4

Aim: Technologies involved in roasting coffee beans, as well as the methods used to prepare infusions, vary according to culture, and contribute to differences in the concentration of elements in the drink. Materials and Methods: Concentrations of six elements: manganese (Mn), cobalt (Co), nickel (Ni), chrome (Cr), silver (Ag) and lead (Pb) were investigated in coffee infusions from eleven samples of coffee, roasted and purchased in four countries: Bosnia and Herzegovina, Brazil, Lebanon and Poland. Metal concentrations were determined using an induction coupled plasma technique in combination with mass spectrometry (ICP-MS, Perkin Elmer) which measures total metal (ionic and non-ionic) content. Results: Metal intake estimated for individual countries (in the respective order; mean consumption per person per year) was as follows: Mn: 26.8-33.1, 28.3-29.5, 29.7, 12.6-18.9 mg; Co: 0.33-0.48, 0.42-0.35, 0.32, 0.12-0.17 mg; Ni: 3.83-5.68, 4.85-5.51, 4.04, 2.06-2.24 mg; Cr: 0.17-0.41, 0.21-0.47, 0.17, 0.09-0.28 mg; Ag: 0.16-1.13, 0.26-0.70, 0.61, 0.33-1.54 mg, Pb: 4.76-7.56, 3.59-5.13, 3.33, 1.48-2.43 mg. Conclusions: This finding gives new data for Mn, Co, Ni, Cr, and Ag intake from coffee , and suggests that the amounts are negligible. However, the data for Pb consumption in heavy drinkers, for example in Bosnia and Herzegovina, indicate that Pb intake from coffee may contribute to the disease burden. The high lead level in some coffees suggests the need for a more precise control of coffee contamination.

7

Taq1B polymorphism of the cholesteryl ester transfer protein gene and CETP activity in members of families with a history of ischaemic heart disease

39%

Wesolowska T., Adler G., Chelstowski K., Ciechanowicz A., Torbus-Lisecka B., Naruszewicz M.

Acta Biochimica Polonica

|

2003

|

tom 50

|

nr Supplement 1

8

Studies of phosphodiesterase effects on adipose tissue metabolism in obese subjects by the microdialysis technique

39%

Flechtner-Mors M., Jenkinson C. P., Alt A., Biesalski H. K., Adler G., Ditschuneit H. H.

Journal of Physiology and Pharmacology

|

2005

|

tom 56

|

nr 3

The effect of non-selective (theophylline) inhibition of cyclic AMP breakdown on norepinephrine stimulated lipolysis rate was investigated in subcutaneous adipose tissue of obese subjects. In addition, changes in interstitial glucose and lactate concentration were assessed by means of the microdialysis technique. The interaction of endogenous released insulin and theophylline on adipocyte metabolism was determined. Theophylline and norepinephrine alone increased glycerol outflow significantly. When both agents were perfused in combination, interstitial glycerol concentration increased further. The enhanced glycerol level due to theophylline application was slightly decreased by insulin. In the presence of theophylline, extracellular glucose concentration increased, in contrast to the catecholamine. Norepinephrine decreased interstitial glucose level. When both drugs were added in combination, the level of interstitial glucose increased to about 1 mM, greater than with theophylline alone. With each intervention, lactate was synthesized. Local adipose tissue blood flow was increased by theophylline and theophylline plus norepinephrine. In conclusion, post-receptor mechanisms increased norepinephrine maximal stimulated lipolysis rate in subcutaneous adipose tissue. Glucose uptake was inhibited by the non-specific inhibitor of phosphodiesterase. The effect of insulin on inhibition of lipolysis was modest but sustained in the presence of high theophylline (10-4 M) concentration. Phosphodiesterase activity may be relatively low in obese subjects in comparison with lean subjects. In lean subjects theophylline caused a transient reversal of the antilipolytic effect of insulin.

9

An age-related decrease in factor V Leiden frequency among Polish subjects

33%

Adler G., Parczewski M., Czerska E., Loniewska B., Kaczmarczyk M., Gumprecht J., Grzeszczak W., Szybinska A., Mossakowska M., Ciechanowicz A.

Journal of Applied Genetics

|

2010

|

tom 51

|

nr 3

Factor V Leiden (G1691A FV mutation) is a widely acknowledged risk factor of deep vein thrombosis, including pulmonary embolism as the most serious complication. However, its high prevalence of ~5% in the Caucasian population might be related to an unknown evolutionary advantage. It might exert a beneficial effect on the carrier, e.g. protecting women from excessive bleeding during labour or allowing increased survival in severe sepsis or with other inflammatory diseases. The aim of our study was to verify or contradict the hypothesis of a favourable association between the A allele (A1691) and longevity in the Polish population. For this purpose, the G1691A mutation was analyzed by PCR-RFLP in 1016 Poles: 400 neonates (187 female and 312 male), 184 healthy adults (129 female and 55 male), and 432 long-lived individuals (age ≥ 95 years: 343 women and 89 men). Frequencies of G1691A carriers and the A1691 allele in long-lived individuals (0.2% and 0.1%, respectively) were significantly lower than in neonates (4.2% and 2.2%, respectively) and adults (3.3% and 1.6%). The frequency of the G1691A factor V Leiden mutation decreased with age, which indicates a shorter survival time among A1691 allele carriers in the Polish population.

10

Genetic screening for glucocorticid-remedible aldosteronism [GRA]: experience of three clinical centres in Poland

33%

Adler G., Widecka K., Peczkowska M., Dobrucki T., Placha G., Drozd R., Parczewski M., Januszewicz A., Gaciong Z., Ciechanowicz A.

Journal of Applied Genetics

|

2005

|

tom 46

|

nr 3

329-332

Glucocorticoid-remediable aldosteronism (GRA), also known as familial hyperaldosteronism type I (FH-I, OMIM 103900), is a monogenic form of inherited hypertension caused by the presence of a chimaeric gene originating from an unequal cross-over between the CYP11B1 (11ß-hydroxylase) and CYP11B2 (aldosterone synthase) genes. The hybrid gene has the CYP11B1 sequence at the 5' end, including the promoter, and the CYP11B2 sequence at the 3' end. The aim of our study was to evaluate the prevalence of GRA in a Polish population of 129 patients with primary hyperaldosteronism (PHA) and 132 patients with essential hypertension (EH), through the use of a PCR-based test revealing the chimaeric gene. None of our PHA or EH patients was positive for the CYP11BHCYP11B2 chimaeric gene. These data suggest that GRA is unlikely to be a common cause of hypertension in Polish subjects. However, the real prevalence of GRA in Poland, both in the high-risk group of individuals with primary hyperaldosteronism and in the general population, remains to be established.

11

Sequence variants of chemokine receptor genes and susceptibility to HIV-1 infection

33%

Parczewski M., Leszczyszyn-Pynka M., Kaczmarczyk M., Adler G., Binczak-Kuleta A., Loniewska B., Boron-Kaczmarska A., Ciechanowicz A.

Journal of Applied Genetics

|

2009

|

tom 50

|

nr 2

159-166

Genetic susceptibility to HIV infection was previously proven to be influenced by some chemokine receptor polymorphisms clustering on chromosome 3p21. Here the influence of 5 genetic variants was studied: Δ32 CCR5, G(-2459)A CCR5, G190A CCR2, G744A CX3CR1 and C838T CX3CR1. They were screened in a cohort of 168 HIV-1 positive adults [HIV(+) group] and 151 newborns [control group] from northwestern Poland. PCR-RFLP was performed to screen for the variants (except for Δ32 CCR5 polymorphism, where PCR fragment size was sufficient to identify the alleles) and then electrophoresed on agarose gel to determine fragment size. Distribution of genotypes and alleles was not significantly different between the groups except for the CCR5 polymorphisms, with the Δ32 allele and the (-2459)A CCR5 allele more frequent among neonates than in the HIV(+) group. No Δ32/Δ32 homozygotes were found in the HIV(+) group, but 16.1% were Δ32/wt heterozygotes. In the control group, 1.3% were Δ32/Δ32 homozygotes and 26.0% were Δ32/wt heterozygotes. Linkage between the chemokine polymorphisms was calculated using the most informative loci for haplotype reconstruction. Haplotypes containing Δ32 CCR5,190G CCR2 and 744A CX3CR1 were found to be significantly more common in the control group. This suggests an association between these haplotypes and resistance to HIV-1 infection.

12

CYP17 and CYP19 genetic variants are not associated with age at natural menopause in Polish women

33%

Rumianowski B., Adler G., Safranow K., Brodowska A., Karakiewicz B., Sluczanowska-Glabowska S., Loniewska B., Piasecka M., Ciechanowicz A., Laszczynska M.

Reproductive Biology

|

2012

|

tom 12

|

nr 4

13

Association between depression, parameters of adiposity and genetic polymorphisms of pro-inflammatory cytokines: IL-1alpha, IL-1Beta, IL-2 and IL-6 in subjects over 55 years old

33%

Adler G., Skonieczna-Zydecka K., Madlani A., Ogonowski J., Grochans E., Pierzak-Sominka J., Brodowski J., Karakiewicz B.

Acta Biochimica Polonica

|

2016

|

tom 63

|

nr 2

Ograniczanie wyników

Bialka wiazace GTP jako uniwersalny przekaznik sygnalow

Udział białek wiążących nukleotydy guanylowe w hormonalnej regulacji cyklazy adenylowej

Tyreoliberyna

The analgesic efficacy of kinesiology taping in delayed Onset Muscle Soreness (DOMS)

Allele frequency distribution of 1691G>A F5 (which confers Factor V Leiden) across Europe, including Slavic populations

Concentrations of heavy metals (Mn, Co, Ni, Cr, Ag, Pb) in coffee

Taq1B polymorphism of the cholesteryl ester transfer protein gene and CETP activity in members of families with a history of ischaemic heart disease

Studies of phosphodiesterase effects on adipose tissue metabolism in obese subjects by the microdialysis technique

An age-related decrease in factor V Leiden frequency among Polish subjects

Genetic screening for glucocorticid-remedible aldosteronism [GRA]: experience of three clinical centres in Poland

Sequence variants of chemokine receptor genes and susceptibility to HIV-1 infection

CYP17 and CYP19 genetic variants are not associated with age at natural menopause in Polish women

Association between depression, parameters of adiposity and genetic polymorphisms of pro-inflammatory cytokines: IL-1alpha, IL-1Beta, IL-2 and IL-6 in subjects over 55 years old