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1

Neuropeptide FF, an endogenous morphine antagonist, in the porcine and bovine central nervous system

100%
Wasowicz K., Panula P.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
2
Content available remote

Cerebral and gastric histamine system is altered after portocaval shunt

71%
Fogel W. A., Michelsen K. A., Panula P., Sasiak K., Andrzejewski W.
Journal of Physiology and Pharmacology
|
2001
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tom 52
|
nr 4,1
Biochemical parameters of the histamine (HA) system were examined in both rat brain and stomach, after portocaval anastomosis (PCA). These tissues become rich in histamine after PCA. Immunocytochemistry was used for brain histamine localisation. In addition to increased HA concentrations, monoamine oxidase B activity increased in both tissues. In hypothalamus HA was 15 fold; in cerebral cortex and in stomach mucosa 2.8 and 2.5 fold of the corresponding controls, respectively. MAO B activity was increased by approximately 50% in brain and 100% in stomach. A significant, uneven increase in tele-methylhistamine concentration was only found in the brain. In stomach mucosa higher histidine decarboxylase activity was found. PCA and sham rats treated with an irreversible inhibitor of MAO B, FA-73, 0.5 mg/kg i.p., showed 24 h later greatly reduced MAO activity and doubled t-MeHA concentration in brain structures. The treatment had no effect on gastric mucosal t-MeHA concentration and on urinary excretion of the t-MeHA metabolite, N-tele-methylimidazoleacetic acid. The HA rise in the stomach of PCA rats is associated with proliferation of histamine producing and storing cells (ECL cells) as demonstrated by others. However, in the brain we saw no indication for increased number of relevant cells either mast cells or neurons and our immunocytochemical findings suggest that in PCA rat brain, histamine deposits are located exclusively in neurons. The data indicate that the adaptative mechanisms to excessive histamine formation are tissue specific.
3
Content available remote

Mouse mammary epithelial histamine system

71%
Wagner W., Ichikawa A., Tanaka S., Panula P., Fogel W. A.
Journal of Physiology and Pharmacology
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2003
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tom 54
|
nr 2
Histamine is suggested to play a role in mammary gland growth regulation, differentiation and functioning during pregnancy and lactation. Two pools of histamine are thought to be involved in these processes: mastocyte- and epithelial cell related histamine. In the present study we focused on epithelial cells. Immunohistochemistry has shown that the epithelial cells positive for histamine and L-histidine decarboxylase (HDC), the primary enzyme regulating histamine biosynthesis, were mainly found in cells forming alveolar structures in the mammary gland. Cultured primary mouse mammary epithelial cells (MMEC) expressed strong HDC immunoreactivity, especially dividing cells and non-differentiated ones. Histidine decarboxylase activity undergoes significant changes during pregnancy and lactation. Pregnancy associated intensive growth of the mammary gland coincided with an increase and the first days of lactation with a decrease of HDC protein expression. Binding studies with mammary tissue membranes and epithelial cell membranes revealed the presence of H1 and H3 but not H2 receptors. Summarizing, our data have shown that mammary epithelial cells are capable of synthesizing and excreting histamine and they bear histamine receptors. These findings further substantiate the role of histamine in mammary gland physiology.
4

Adaptive changes in histamine metabolism after portocaval shunt concern stomach and brain

71%
Fogel W. A., Michelsen K., Panula P., Sasiak K., Andrzejewski W.
Journal of Physiology and Pharmacology. Supplement
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2001
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tom 52
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nr 2
5

Histaminergic mechanisms in brain development, injury and repair

61%
Panula P., Lintunen M., Peitsaro N., Kaslin J., Michelsen K. A., Anichtchik O., Karlstedt K.
Acta Neurobiologiae Experimentalis
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1999
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tom 59
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nr 3
6

Brain VMAT2 unchanged in portocavally shunted rats

61%
Fogel W. A., Michelsen K., Lewinski A., Panula P., Maksymowicz M., Stasiak A.
Acta Neurobiologiae Experimentalis
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2005
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tom 65
|
nr 3
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