The objective of this study was to investigate the relative changes in serum lipid, lipoprotein and trace element levels in babesiosis before and after treatment with diminazene aceturate (Berenil®). Babesiosis was determined with the help of the indirect fluorescent antibody test (IFAT). Cattle with babesiosis exhibited a significant increase in serum triglyceride and VLDL cholesterol levels compared to the control group. On the other hand, cattle with babesiosis had significantly lower total cholesterol, HDL cholesterol, LDL cholesterol, Fe, and Cu levels when compared to the control group. In conclusion, notable changes in lipid, lipoprotein and trace element levels were determined in cattle with babesiosis. Also we have determined a relationship between lipid and mineral metabolism in the bovine babesiosis.