Wyniki wyszukiwania

1

Capacity for transformation and phage AS1M plaque morphology as additional criteria differentiating between Synechococcus cedrorum and Anacystic nidulans

100%

Nieradko J., Bielawski K.

Acta Microbiologica Polonica

|

1986

|

tom 35

|

nr 3-4

2

Hemolityczna aktywnosc paleczek Klebsiella pneumoniae i Klebsiella oxytoca

81%

Szramka B., Kurlenda J., Bielawski K.

Medycyna Doświadczalna i Mikrobiologia

|

1998

|

tom 50

|

nr 3-4

207-213

Niniejsza praca przedstawia wyniki badań nad aktywnością hemolityczną wybranych szczepów Klebsiella pneumoniae i Klebsiella oxytoca. Badane szczepy wykazywały aktywność hemolityczną specyficzną wobec erytrocytów króliczych. Hemoliza występowała tylko po inkubacji hodowli z ß-merkaptoetanolem lub chlorkiem wapnia.

3

Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d[CGCGAATTCGCG]2

81%

Bielawski K., Bielawska A., Bartulewicz D., Rozanski A.

Acta Biochimica Polonica

|

2000

|

tom 47

|

nr 3

A molecular mechanics and molecular dynamics approach was used to examine the structure of complexes formed between the d(CGCGAATTCGCG)2 duplex and netropsin, distamycin, and four carbocyclic analogues of netropsin and distamycin (1-4). The resulting structures of the ligand-DNA model complexes and their energetics were examined. It is predicted that the compounds 1-4 should have a decreased affinity for the minor groove of AT-rich regions in comparison to netropsin and distamycin. From the energetic analysis it appears that van der Waals and electrostatic interactions are more important than specific hydrogen bonds in stabilizing the ligand-duplex complexes. We predict that compounds 1 and 2 are effectively isohelical with the DNA minor groove. The superior DNA-binding afforded by 1 and 2 in comparison to 3 and 4 results from their more effective penetration into the minor groove and smaller perturbation of molecular structure upon complex formation.

4

DNA-binding properties and cytotoxicity of biscationic extended diphenylfurans derivatives: effects of the terminal basic side chains

81%

Bielawski K., Bielawska A., Wolczynski S.

Folia Histochemica et Cytobiologica. Supplement

|

2001

|

tom 39

|

nr 1

5

L-proline analogues of anthraquinone-2-carboxylic acid as prolidase-activated prodrugs: cytotoxic activity in breast cancer MCF-7 cells and inhibitory activity against topoisomerase I and II

81%

Bielawska A., Bielawski K., Palka J., Kosk K.

Folia Histochemica et Cytobiologica. Supplement

|

2001

|

tom 39

|

nr 1

6

Spermine protects in vivo the antioxidant enzymes in transiently hypoperfused rat brain

81%

Farbiszewski R., Bielawski K., Bielawska A., Sobaniec W.

Acta Neurobiologiae Experimentalis

|

1995

|

tom 55

|

nr 4

7

Inhibitory effects of pentamidine analogues on protein biosynthesis in vitro

81%

Bielawski K., Galicka A., Bielawska A., Sredzinska K.

Acta Biochimica Polonica

|

2000

|

tom 47

|

nr 1

Pentamidine despite its rather high toxicity, is currently in clinical use. For development of new drugs of this type it is important to know the mechanism of their action. Two new amidines (I and II) and 4',6-diamidino-2-phenylindole (DAPI) were found in preliminary experiments to inhibit protein synthesis in vitro in the cell-free rat liver system. The three compounds differed in the precise mode of action. The inhibitory effect of I on the activity of the eukaryotic elongation factor eEF-2 and ribosomes seems to suggest that the binding site of eEF-2 on the ribosome was blocked by this compound. eEF-2 has been identified as the primary target of II and eEF-1 as the primary target of DAPI in the system studied.

8

New carbocyclic analogues of netropsin: synthesis and inhibition of topoisomerases

81%

Puckowska A., Bielawski K., Bielawska A., Rozanski A.

Acta Biochimica Polonica

|

2002

|

tom 49

|

nr 1

A series of carbocyclic analogues of netropsin were synthesized and evaluated for their capacity to inhibit human topoisomerases I and II in vitro. The compounds are oligopeptides containing 1,4-di- and 1,2,5-trisubstituted benzene rings and unsubstituted N-terminal NH2 groups. Compounds 4-7 consist of two netropsin-like units linked by aliphatic (tetra- and hexamethylene) chains. In the topoisomerase I and II assay, the relaxation of pBR322 plasmid was inhibited by compounds 4-7 at 100 uM concentration.

9

Novel dinuclear platinum(II) complexes targets NFkappaB signaling pathway to induce apoptosis and inhibit metabolism of MCF-7 breast cancer cells

71%

Poplawska B., Bielawska A., Surazynski A., Czarnomysy R., Bielawski K.

Folia Histochemica et Cytobiologica

|

2009

|

tom 47

|

nr 5

10

Cytotoxicity of chemically modified derivatives of ouabin, digoxin and proscillaridin A

71%

Winnicka K., Sosnowska K., Bielawska A., Bielawski K., Surazynski A.

Acta Biochimica Polonica

|

2006

|

tom 53

|

nr Supplement 1

11

Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay

71%

Vogt U., Falkiewicz B., Bielawski K., Bosse U., Schlotter C. M.

Acta Biochimica Polonica

|

2000

|

tom 47

|

nr 1

A pilot study on relationships of selected molecular factors [erbB-1, erbB-2, erbB-3, and c-myc oncogene average gene copy numbers (AGCN); steroid receptors and pS2 gene expression; tumor cells' DNA values] to the ex vivo chemosensitivity of ovarian cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Despite the relatively small number of patients, numerous correlations among the factors tested were found. Nevertheless, only c-myc gene dosage positively affected ex vivo chemosensitivity of tumors tested.

12

C-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer

71%

Falkiewicz B., Schlotter C. M., Bosse U., Bielawski K., Vogt U.

Acta Biochimica Polonica

|

2000

|

tom 47

|

nr 1

A pilot study on relationships of selected molecular factors (c-myc oncogene average gene copy numbers (AGCN); serum CEA and CA 15.3 antigen levels; tumor cells' DNA values), to the ex vivo chemosensitivity of primary female human breast cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Four drug combinations were tested. A group of 75 cases of female primary breast cancer was assessed. Numerous correlations were found among molecular factors tested but none, with the exception of tumor grading, of these reflected ex vivo chemosensitivity of tumors tested. The results suggest that the parameters tested may not be important factors related to adjuvant chemoresponsiveness of primary human breast cancer to tested drug combinations

13

Cytotoxicity, DNA strand breakage and topoisomerase inhbition of novel Pt-berenil compounds

61%

Bolkun U., Bielawski K., Bielawska A., Surazynski A., Winnicka K., Werpachowska J., Szkudlarek I.

Acta Biochimica Polonica

|

2006

|

tom 53

|

nr Supplement 1

14

Elevated plasma levels of tissue factor as a valuable diagnostic biomarker with relevant efficacy for prediction of breast cancer morbidity

61%

Zarychta E., Rhone P., Bielawski K., Rosc D., Szot K., Zdunska M., Ruszkowska-Ciastek B.

Journal of Physiology and Pharmacology

|

2018

|

tom 69

|

nr 6

15

Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A

61%

Winnicka K., Bielawska A., Bielawski K., Miltyk W., Szturgulewska A., Gorska B.

Acta Biochimica Polonica

|

2006

|

tom 53

|

nr Supplement 1

16

Assessment of leptin-to-adiponectin ratio in prediction of insulin resistance and nutrition status in a geriatric female population

61%

Biercewicz M., Slusarz R., Kedziora-Kornatowska K., Filipska K., Bielawski K., Ruszkowska-Ciastek B.

Journal of Physiology and Pharmacology

|

2020

|

tom 71

|

nr 1

17

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Pro-inflammatory cytokines in saliva of adolescents with dental caries disease

61%

Gornowicz A., Bielawska A., Bielawski K., Grabowska S. Z., Wojcicka A., Zalewska M., Maciorkowska E.

Annals of Agricultural and Environmental Medicine

|

2012

|

tom 19

|

nr 4

18

Construction of a DNA-polymerase i overproducting plasmid and isolation of the enzyme

61%

Bielawski K., Skowron P., Kur J., Konopa G., Podhajska A., Taylor K.

Acta Biochimica Polonica

|

1987

|

tom 34

|

nr 1

19

Heparanase link between vasculogenesis and angiogenesis as well as a predictive factor of a shorter survival rate

61%

Bielawski K., Rhone P., Bielawska S., Rosc D., Brkic A., Zarychta E., Ruszkowska-Ciastek B.

Journal of Physiology and Pharmacology

|

2019

|

tom 70

|

nr 3

20

Synthetic analogues of netropsin and distamycin-synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics

61%

Bartulewicz D., Bielawski K., Markowska A., Zwierz K., Puckowska A., Rozanski A.

Acta Biochimica Polonica

|

1998

|

tom 45

|

nr 1

A new series of pyridine-containing analogues III-XXII of distamycin A and netropsin was investigated by the molecular mechanics technique and molecular modelling. A pyridine analogue of netropsin (VII) is described, the first compound based on molecular studies, and two carbocyclic analogues of distamycin A with an N-terminal chloro- or bromoacetyl group (VIa, VIIa) were synthesized, as well as carbocyclic analogues of netropsin (VIIIb, Xb), potential carriers of alkylating elements. The potential use of VIa, VII, VIIa, VIIIb and Xb as carriers to place into the minor groove of DNA chemical groups capable of modifying DNA, is discussed.

Ograniczanie wyników

Capacity for transformation and phage AS1M plaque morphology as additional criteria differentiating between Synechococcus cedrorum and Anacystic nidulans

Hemolityczna aktywnosc paleczek Klebsiella pneumoniae i Klebsiella oxytoca

Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d[CGCGAATTCGCG]2

DNA-binding properties and cytotoxicity of biscationic extended diphenylfurans derivatives: effects of the terminal basic side chains

L-proline analogues of anthraquinone-2-carboxylic acid as prolidase-activated prodrugs: cytotoxic activity in breast cancer MCF-7 cells and inhibitory activity against topoisomerase I and II

Spermine protects in vivo the antioxidant enzymes in transiently hypoperfused rat brain

Inhibitory effects of pentamidine analogues on protein biosynthesis in vitro

New carbocyclic analogues of netropsin: synthesis and inhibition of topoisomerases

Novel dinuclear platinum(II) complexes targets NFkappaB signaling pathway to induce apoptosis and inhibit metabolism of MCF-7 breast cancer cells

Cytotoxicity of chemically modified derivatives of ouabin, digoxin and proscillaridin A

Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay

C-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer

Cytotoxicity, DNA strand breakage and topoisomerase inhbition of novel Pt-berenil compounds

Elevated plasma levels of tissue factor as a valuable diagnostic biomarker with relevant efficacy for prediction of breast cancer morbidity

Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A

Assessment of leptin-to-adiponectin ratio in prediction of insulin resistance and nutrition status in a geriatric female population

Pro-inflammatory cytokines in saliva of adolescents with dental caries disease

Construction of a DNA-polymerase i overproducting plasmid and isolation of the enzyme

Heparanase link between vasculogenesis and angiogenesis as well as a predictive factor of a shorter survival rate

Synthetic analogues of netropsin and distamycin-synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics