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1

Concentration of endothelin in plasma and BAL fluid from asthmatic patients

100%

Gawlik R., Jastrzebski D., Ziora D., Jarzab J.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

103-110

The bronchoconstrictive peptide endothelin-1 (ET-1) has been demonstrated in the airway epithelial and endothelial cells. In this study we investigated the pathophysiological significance of endothelin-1 in asthma. We addressed the issue by assessing the concentration of ET-1 in plasma and bronchoalveolar lavage fluid (BALF) in patients with a different intensity of asthma. Twenty one asthmatic patients (11 men,10 women) and 6 healthy control subjects (C) were included in the study. Eleven asthmatic patients were classified as moderate persistent asthma (SA), all of them were atopic, and another 10 were mild persistent asthmatics (AA). Lung function tests were carried out in all patients investigated. The ET-1 concentration was determined by an ELISA method in plasma and BALF. We found that the SA patients haed the highest level of ET-1 (SA - 11.4 ±3.6 fmol/ml; AA - 7.1 ±2.7 fmol/ml; C - 5.6 ±1.8 fmol/ml) in BALF. The same concerned the ET-1 level in plasma (SA - 27.8 ±3.8 fmol/ml; AA - 18.1 ±4.3 fmol/ml; C - 17.3 ±3.0 fmol/ml). A positive correlation between the plasma ET-1 level and lung function indices was observed. We conclude that the higher levels of ET-1 in more severe asthma suggest that endothelins may contribute to the pathophysiology of the disease, its severity, and the regulation of bronchial tone.

2

Induced sputum metalloproteinases and their inhibitors in relation to exhaled nitrogen oxide and sputum nitric oxides and other inflammatory cytokines in patients with chronic obstructive pulmonary disease

100%

Ziora D., Dworniczak S., Kozielski J.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

809-817

3

Moderate exercise decreases nitric oxide exhalation in patients with stable coronary artery disease

100%

Nadziakiewicz P., Knapik P., Ziora D., Nowak D.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

213-221

Nitric oxide (NO) is present in exhaled air in humans and its level may decrease in heart diseases. Nitrates are metabolized to NO. In the present study we prospectively investigated how coronary disease treated with oral nitrates and physical exercise influence the exhaled NO concentration (exNO). The study was performed in 44 patients with stable coronary artery disease (CAD) treated with oral nitrates (31 nonsmokers and 13 smokers) and 34 healthy volunteers (21 nonsmokers and 13 smokers). End-tidal concentration of exhaled NO was measured by the use of a chemiluminescence method. The Bruce protocol of an exercise test was performed in 21 coronary patients and 11 volunteers. NO was measured before and 2-5 min after the test. We found no significant differences in the exNO level between healthy controls and CAD patients as analyzed either for the whole groups or non-smoker and smoker subgroups (6.01 parts per billion (ppb) vs. 4.91 ppb; 7.02 ppb vs. 5.89 ppb; 3.62 ppb vs. 3.33 ppb, respectively). However, the coronary patients group, as a whole, had lower exNO after exercise (4.22 ppb vs. 3.84 ppb, P<0.01). The difference persisted after division of this group into non-smokers and smokers: 5.19 ppb vs. 4.79 ppb, P<0.05 and 3.63 ppb vs. 3.27 ppb, P<0.05, respectively). The level of exNO changed inappreciably after exercise in control subjects. We conclude that coronary disease and oral nitrates, in themselves, do not influence the exhaled NO concentration. Physical exercise, on the other side, lowers the exhaled NO level in coronary patients.

4

Correlation of spirometric parameters taken at a single examination with the quality of life in children with stable asthma

88%

Ziora D., Madaj A., Wieckowska E., Ziora K., Kozielski J.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

5

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High-resolution computer tomography in hypersensitivity pneumonitis-correlation with pulmonary function

88%

Ziora D., Jastrzebski D., Lubina M., Wojdala A., Kozielski J.

Annals of Agricultural and Environmental Medicine

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2005

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tom 12

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nr 1

In 20 patients with chronic form of hypersensitivity pneumonitis (HP) pulmonary function tests (FEV1, FVC, DCO) and high resolution computed tomography (HRCT) scans were obtained. Extent of pathological changes, i.e. nodularity, lines, honeycombing but not ground-glass estimated by HRCT and expressed as a score correlated significantly with lung function abnormalities.

6

Potential confounding factors in measurement of exhaled nitric oxide

76%

Nadziakiewicz P., Knapik P., Rozentryt P., Ziora D., Dworniczak S., Kozielski J., Polonski L.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

223-228

Nitric oxide is present in the exhaled air. Factors affecting the level of exhaled nitric oxide (exNO), except for smoking, are not well defined. In this study we seek to determine whether age, gender, body mass index (BMI), part of the day, or time after a meal could modulate exNO levels. exNO was examined by the use of a chemiluminescence method in 100 subjects - 31 women (19 nonsmokers and 12 smokers) and 69 males (55 nonsmokers and 14 smokers). Forty four subjects took medications due to stable coronary disease, 22 were after heart transplantation, and 34 did not take any drugs. We found that exNO levels did not differ either between the whole groups of women and men or between smokers and nonsmokers of either respective group (4.91 ±2.38 vs. 6.27 ±4.23 ppb; 3.21 ±1.16 vs. 3.71 ±1.55 ppb; 5.98 ±2.35 vs. 6.92 ±4.45 ppb). The correlation of exNO with age in the whole population was weak (r=0.23; P=0.02) and insignificant in the smoking and nonsmoking subgroups. Likewise, correlations of exNO with BMI, part of the day, or time after a meal were insignificant in whole population as well as the subgroups. We conclude that the aforementioned factors are not able to confound the measurement of exNO in the population studied.

7

Late consequences of respiratory system burns

76%

Krzywiecki A., Ziora D., Niepsuj G., Jastrzebski D., Dworniczak S., Kozielski J.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

8

Quality of life during one-year observation of patients with idiopathic pulmonary fibrosis awaiting lung transplantation

76%

Jastrzebski D., Kozielski J., Banas A., Cebula T., Gumola A., Ziora D., Krzywiecki A.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 4

99-105

The aim of the study was to evaluate the quality of life and its changes in patients with idiopathic pulmonary fibrosis (IPF), waiting for lung transplantation. Sixteen IPF patients, who qualified for lung transplantation, and 14 chronic obstructive pulmonary disease (COPD) patients on long term oxygen therapy, taken as a reference group, were assessed. The quality of life was estimated twice, using an SF-36-questionnaire, at the time of qualification for lung transplantation and 12 months later. The IPF and reference patients had similarly profound disturbances in lung function and arterial blood gas content. The IPF patients had a statistically greater score in their physical functioning (PF; 45 vs. 18), the role of limitations due to physical problems (RP; 43 vs. 11), social functioning (SF; 58 vs. 30), and the role of emotional limitations in everyday life (RE; 65 vs. 12) than the reference ones. After a year's observation, there were no differences in SF-36 questionnaire results, except for the role of limitations due to physical problems (RP). A correlation was noted between spirometry and blood gas results and SF-36 questionnaire results in IPF patients qualified for lung transplantation. There was a positive correlation between the partial pressure of oxygen (PaO2), on one side, and mental and general health, on the other. There also were positive correlations between FEV1 and SF and FEV1 and the level of bodily pain (BP). We conclude that the SF-36 questionnaire is a sensitive tool to assess the quality of life in IPF patients qualified for lung transplantation. The information gained can help assess the severity of the disease, clinical symptoms, and functional impairment in these patients.

9

Correlation of exhaled nitric oxide with nitrogen oxides and selected cytokines in induced sputum of chronic obstructive pulmonary disease patients

76%

Ziora D., Dworniczak S., Kaczmarczyk G., Jastrzebski D., Krzywiecki A., Kozielski J.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

10

Prognostic risk factors in patients with interstitial lung disease referred for lung transplantation

64%

Jastrzebski D., Kozielski J., Nowak J., Zielinska-Les I., Ziora D., Szulik B., Wojarski J., Zakliczynski M., Zembala M.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 4

107-113

The aim of the study was to identify prognostic factors that would differentiate patients with interstitial lung disease between those with and without a chance to survive until lung transplantation. A retrospective study was performed in patients with interstitial lung disease referred for lung transplantation between September 1999 and April 2005. The analysis included the demographic data, the time from referral to transplantation, the functional tests (FVC, FEV1, FEV1%VC, the PaO2 at rest and after oxygen supplementation via a nasal catheter), the count of NYHA functional classes, the left ventricular ejection fraction (EF), the distance covered during a 6-min walk test, and the pathogens in the respiratory tract. The patients were divided into two groups: Group 1 - lung transplant candidates who survived until the successful procedure and Group 2 - lung transplant candidates who died while on the waiting list. There were statistical differences between the two groups in PaO2 after supplementation (P=0.005), EF (P=0.002), and the 6-min walk distance (P=0.001). It appears that simple functional tests of the cardiorespiratory system may define survival of patients with interstitial lung disease waiting for lung transplantation.

11

Human cytomegalovirus DNA level in patients with idiopathic pulmonary fibrosis

64%

Dworniczak S., Ziora D., Kapral M., Mazurek U., Niepsuj G., Rauer R., Wilczok T., Kozielski J.

Journal of Physiology and Pharmacology. Supplement

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2004

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tom 55

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nr 3

67-75

The objectives of the study were to estimate human cytomegalovirus (HCMV) DNA copy number in broncho-alveolar lavage cells, blood leukocytes, and serum of patients with idiopathic pulmonary fibrosis (IPF). The study groups consisted of 16 patients, newly diagnosed with IPF and never treated, (mean age 40.9 ±11.0 yr; F/M-7/9) and in 16 adult healthy volunteers (mean age 36.8 ±6.4 yr; F/M-4/12) used as controls. The HCMV DNA copy number was calculated by a Q-PCR method using TaqMan ABI PRISMTM7700. We found that the prevalence of the HCMV DNA positive subjects in the patient group (75%) did not differ significantly from that in the control group (69%). We also found that in both patient and control groups the mean HCMV DNA copy number in BAL cells was significantly higher than that in blood leukocytes (log10=2.7 vs. 1.2 for patients and 2.8 vs. 0.9 for controls, respectively). However, a higher HCMV DNA copy number in blood serum was observed in IPF patients than in controls (log10=3.2 vs. 2.0, respectively). We conclude that the lungs play an important role in the human pathobiology of cytomegalovirus sustenance.

12

Spirometric parameters in malnourished girls with anorexia nervosa

64%

Ziora K., Ziora D., Oswiecimska J., Roczniak W., Machura E., Dworniczak S., Tomalak W., Dyduch A.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

801-807

13

Left ventricular dysfunction in patients with interstitial lung diseases referred for lung transplantation

64%

Jastrzebski D., Nowak J., Ziora D., Wojarski J., Czyzewski D., Kozielski J., Polonski L., Zembala M.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

|

nr 5

Ograniczanie wyników

Concentration of endothelin in plasma and BAL fluid from asthmatic patients

Induced sputum metalloproteinases and their inhibitors in relation to exhaled nitrogen oxide and sputum nitric oxides and other inflammatory cytokines in patients with chronic obstructive pulmonary disease

Moderate exercise decreases nitric oxide exhalation in patients with stable coronary artery disease

Correlation of spirometric parameters taken at a single examination with the quality of life in children with stable asthma

High-resolution computer tomography in hypersensitivity pneumonitis-correlation with pulmonary function

Potential confounding factors in measurement of exhaled nitric oxide

Late consequences of respiratory system burns

Quality of life during one-year observation of patients with idiopathic pulmonary fibrosis awaiting lung transplantation

Correlation of exhaled nitric oxide with nitrogen oxides and selected cytokines in induced sputum of chronic obstructive pulmonary disease patients

Prognostic risk factors in patients with interstitial lung disease referred for lung transplantation

Human cytomegalovirus DNA level in patients with idiopathic pulmonary fibrosis

Spirometric parameters in malnourished girls with anorexia nervosa

Left ventricular dysfunction in patients with interstitial lung diseases referred for lung transplantation