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Pharmacokinetics and pharmacodynamics of terguride following intramuscular administration in cows and goats

100%

Lapka R., Krejci P., Lidicky J., Fruhaufova M., Rezabek K.

Acta Physiologica Polonica

1989

tom 40

nr 1

Łapka R. Krejči, P. Lidický, J., Frühaufová, M. and Rezábek, K.: Pharmacokinetics and pharmacodynamlics of terguride following intramuscular administration in cows and goats. Acta physiol. pol., 1989, 40 (1): 139-144. The (pharmacokinetics of intramuscular terguride (transdihydrolisuride) was evaluated in a single-dose study in cows (doses 100, 62 and 31 μg/kg b.w.) and goats (dose 100 μg/kg b.w.). A radioreceptor assay was used to quantitative plasma terguride concentrations. The peak plasma concentrations of terguride were attained within 0.6 h of the drug administration and then decreased monoexponentially with half-life of 1.3 h (cows) and 2 h (goats). The pharmacokinetics of terguride in cows is nearly linear. Pharmacodynamics of terguride was expressed as reduction in plasma prolactin levels. Maximal decline in prolactin was observed 3-4 h following terguride administration and the effect lasted for about 24 h.

Ograniczanie wyników

1 Acta Physiologica Polonica

1 Fruhaufova M.

1 Krejci P.

1 Lapka R.

1 Lidicky J.

1 Rezabek K.

1 1989

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Pharmacokinetics and pharmacodynamics of terguride following intramuscular administration in cows and goats