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The aim of this study was to compare diagnostic techniques for the assessment of cartilage damage in the carpal and fetlock joints in horses with arthritis. The techniques compared were synovial fluid analysis, as well as radiographic, thermographic, ultrasonographic, and arthroscopic examinations. Sixteen horses of both sexes with arthritis, weighing 438 ± 51 kg and at different ages were used as material. Before a detailed examination, an evaluation of the conformation and symmetry of the musculoskeletal system was performed. Nerve blocks definitively localized lameness to a specific site. Thermographic, radiographic, ultrasonographic, and arthroscopic examinations were performed after routine clinical examination. Synovial fluid and sera were collected for further analysis. In conclusion, although all examination techniques may yield useful information, their severe limitations were revealed, particularly in the detection of early articular cartilage damage. Arthroscopy is more reliable than other methods in cases of joint capsule lesions and intra-capsular lesions, as well as cartilage and synovial hyperplasia. Arthroscopy is considered to be advantageous and necessary.
Osteoarthritis (OA) is a common cause of lameness, pain, and dysfunction in dogs. To determine the levels of interleukin (IL) (IL-1β, IL-6, IL-10), tumor necrosis factor (TNF)-α, and prostaglandin E₂ (PG-E₂) in the synovial fluid after intra-articular injection of an autologous platelet-rich plasma concentrate to treat dogs with osteoarthritis. Twenty dogs with osteoarthritis (OA) were used as a materials. Fourteen dogs were used as a platelet-rich plasma (PRP) treatment group and 6 dogs were used as a control (0.9 % NaCl). PRP was obtained by the double centrifuge method. Affected joints were examined by radiography and ultrasonography. Lameness and pain severity were evaluated by attending clinicians. Samples were collected under sterile conditions at pre-treatment, days 1, 3, 5, 7, 15, and weeks 4, 8, and 12. The marker levels were determined by an enzyme-linked immunosorbent assay. No adverse effects of the injection of platelet concentrate or saline solution were observed. No significant differences were found in the Hudson Visual Analog Scale and Canine Brief Pain Inventory scores between weeks 0, 4, and 12 in the control dogs. No significant changes were observed in IL-1β, IL-6, IL-10, TNF-α, and PG-E₂ levels (P>0.05) in synovial fluid from the PRP treatment group compared to synovial fluid from the control group, although fluctuations in parameter levels were observed in both groups. Despite some variable results in inflammatory parameters, clinical improvement was recorded in the PRP-treated group. PRP injection could be an effective and safe method for treatment of dogs with osteoarthritis.
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