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Wplyw produktow ekskrecyjno-sekrecyjnych Fasciola hepatica na funkcjonowanie hepatocytow szczurzych

100%
Gajewska A., Smaga-Kozlowska K., Kotomski G.
Medycyna Weterynaryjna
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2006
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tom 62
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nr 04
459-462
Fasciolosis, caused by Fasciola hepatica is a hepatic parasitic infection that affects numerous mammal species mainly ruminants, and is still a major veterinary problem in Poland causing huge economic losses in the cattle industry. The economic significance of fasciolosis is mainly due to direct losses caused by decrease in weight gain, milking capacity and the confiscation of altered livers in slaughterhouse. The molecular mechanisms of host-parasite interactions are still little known. The aim of the study was to investigate changes in the metabolic activity of freshly isolated rat hepatocytes exposed to excretory-secretor products (ESP) of Fasciola hepatica. The metabolic activity of isolated hepatocytes was determined with MTT and enzyme leakage tests. Hepatocytes were incubated with 0-1 mg/ml ES proteins from 2 to 72 hours. It was found that both the concentration and longevity of ESP action may hamper the metabolic activity of hepatocytes. Decrease in the metabolic activity of the cells correlated with an increase in enzyme leakage (ALT, ASPAT and LDH). Moreover, it was found that the level of albumin in the medium gradually decreased after 24 hrs of incubation with EPS, which may have resulted from an alternation of protein synthesis in the cells treated with the liver fluke metabolites. In conclusion, the results of the study indicate that ESP of Fasciola hepatica plays an important role in damaging liver cells of the host during invasions.
2
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The alterations of glutathione level in rat liver cells after exposure to Fasciola hepatica proteins

100%
Gajewska A., Smaga-Kozlowska K., Wesolowska A., Kotomski G.
Wiadomości Parazytologiczne. Suplement
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2007
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tom 53
3
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Zmiany patologiczne watroby w inwazji przywry Fasciola hepatica

100%
Gajewska A., Smaga-Kozlowska K., Wisniewski M.
Wiadomości Parazytologiczne
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2005
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tom 51
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nr 2
115-123
Pathological changes of liver in infection of Fasciola hepatica. Fasciolosis caused by Fasciola hepatica is a hepatic parasitic infection that affects numerous mammal species, mainly ruminants, in several countries of Europe, Asia and America. The economic significance of fasciolosis is mainly due to direct losses caused by a decrease of weight rate, milking capacity and the confiscation of altered livers in slaughterhouse. In this review we present mechanisms of damaging of host liver during invasion of Fasciola hepatica. Parasites digest hepatic tissue and cause extensive parenchymal destruction with intensive haemorrhagic lesions and immunological reactions. Mechanical liver damage is due to migrating juvenile fluke. Macerated hepatic cells have been observed inside the oral sucker and pharynx. Moreover, the process of ulceration of liver tissue was observed in regions adjacent to the spiny body of fluke tegument. On the other hand, the injury of the liver can be induced chemically by factors produced or induced by the fluke. Probably, fluke proteases and other tissue-degrading enzymes can be responsible for negative effect on liver parenchyma. There is no evidence to link fluke-enzymes with tissue penetration. The consequences of liver damage resulting from the migrating flukes compromises liver function which is reflected in changes of plasma protein concentration (albumin, globulin). Additianally, changes of levels of hepatic enzymes released into the blood as a result of damage of liver tissue are used to monitor the progress of the infection in a variety of Fasciola hepatica hosts and as a sensitive diagnostic aid in field infection.
4
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Apoptosis induction in rat hepatocytes after treatment with Fasciola hepatica somatic proteins

100%
Gajewska A., Smaga-Kozlowska K., Jedlina-Panasiuk L., Kotomski G.
Wiadomości Parazytologiczne. Suplement
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2007
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tom 53
5
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Acomparison of protectivity of cDNAvaccination against Fasciola hepatica infections using a novel cathepsin L (FhPcW2) and previously tested cathepsin Ls

76%
Jaros S., Januszkiewicz K., Smaga-Kozlowska K., Wesolowska A., Zygner W., Wedrychowicz H.
Wiadomości Parazytologiczne. Suplement
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2007
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tom 53
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